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TPPP tubulin polymerization promoting protein [ Bos taurus (cattle) ]

Gene ID: 280968, updated on 27-Aug-2018

Summary

Official Symbol
TPPPprovided by VGNC
Official Full Name
tubulin polymerization promoting proteinprovided by VGNC
Primary source
VGNC:VGNC:36258
See related
BGD:BT20541; Ensembl:ENSBTAG00000047116
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
p25
Orthologs

Genomic context

See TPPP in Genome Data Viewer
Location:
chromosome: 20
Exon count:
6
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 20 NC_037347.1 (71467587..71488493)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 20 AC_000177.1 (71561964..71570566, complement)

Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene bromodomain containing 9 Neighboring gene probable palmitoyltransferase ZDHHC11B Neighboring gene uncharacterized LOC104975299 Neighboring gene centrosomal protein 72 Neighboring gene solute carrier family 9 member A3 Neighboring gene uncharacterized LOC112443025

Genomic regions, transcripts, and products

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
microtubule bundle formation IDA
Inferred from Direct Assay
more info
PubMed 
microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule bundle IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
tubulin polymerization-promoting protein
Names
25 kDa brain-specific protein
brain-specific protein p25 alpha
p25-alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173976.3NP_776401.1  tubulin polymerization-promoting protein

    See identical proteins and their annotated locations for NP_776401.1

    Status: VALIDATED

    Source sequence(s)
    NKLS02000020
    UniProtKB/Swiss-Prot
    Q27957
    Related
    ENSBTAP00000054983.1, ENSBTAT00000064550.1
    Conserved Domains (1) summary
    pfam05517
    Location:51206
    p25-alpha; p25-alpha

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037347.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    71467587..71488493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024981197.1XP_024836965.1  tubulin polymerization-promoting protein isoform X2

    Conserved Domains (1) summary
    pfam05517
    Location:51206
    p25-alpha; p25-alpha
  2. XM_024981198.1XP_024836966.1  tubulin polymerization-promoting protein isoform X2

    Conserved Domains (1) summary
    pfam05517
    Location:51206
    p25-alpha; p25-alpha
  3. XM_024981196.1XP_024836964.1  tubulin polymerization-promoting protein isoform X1

    Conserved Domains (1) summary
    pfam05517
    Location:92247
    p25-alpha
  4. XM_024981199.1XP_024836967.1  tubulin polymerization-promoting protein isoform X2

    Conserved Domains (1) summary
    pfam05517
    Location:51206
    p25-alpha; p25-alpha
  5. XM_024981200.1XP_024836968.1  tubulin polymerization-promoting protein isoform X2

    Conserved Domains (1) summary
    pfam05517
    Location:51206
    p25-alpha; p25-alpha
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