U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TNF tumor necrosis factor [ Bos taurus (domestic cattle) ]

Gene ID: 280943, updated on 5-Sep-2025
Official Symbol
TNFprovided by VGNC
Official Full Name
tumor necrosis factorprovided by VGNC
Primary source
VGNC:VGNC:36153
See related
BGD:BT10618
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
TNFa; TNF-a; TNF-alpha
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See TNF in Genome Data Viewer
Location:
chromosome: 23
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (27716170..27718943, complement)

Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene natural cytotoxicity triggering receptor 3 Neighboring gene allograft inflammatory factor 1 Neighboring gene leukocyte specific transcript 1 Neighboring gene uncharacterized LOC100847561 Neighboring gene lymphotoxin beta Neighboring gene lymphotoxin alpha Neighboring gene NFKB inhibitor like 1

Genomic Sequence:
NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Alterations in TNF-α and its receptors expression in cows undergoing heat stress. Lendez PA, et al. Vet Immunol Immunopathol, 2021 May. PMID 33799007
  2. Effects of tumor necrosis factor-alpha and nitric oxide on prostaglandins secretion by the bovine oviduct differ in the isthmus and ampulla and depend on the phase of the estrous cycle. Siemieniuch MJ, et al. Exp Biol Med (Maywood), 2009 Sep. PMID 19596830
  3. Gene expression of tumour necrosis factor and insulin signalling-related factors in subcutaneous adipose tissue during the dry period and in early lactation in dairy cows. Sadri H, et al. J Anim Physiol Anim Nutr (Berl), 2010 Oct. PMID 20579185
  4. Daily injection of tumor necrosis factor-{alpha} increases hepatic triglycerides and alters transcript abundance of metabolic genes in lactating dairy cattle. Bradford BJ, et al. J Nutr, 2009 Aug. PMID 19549751
  5. Tumor necrosis factor-α inhibits the stimulatory effect of luteinizing hormone and prostaglandin E(2) on progesterone secretion by the bovine corpus luteum. Szóstek AZ, et al. Domest Anim Endocrinol, 2011 May. PMID 21256693

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Alterations in TNF-alpha and its receptors expression in cows undergoing heat stress.
    Title: Alterations in TNF-α and its receptors expression in cows undergoing heat stress.
  2. Data suggest that luteolytic factors (such as TNFa, interferon gamma, and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.
    Title: Expression of matrix metalloproteinases in bovine luteal cells induced by prostaglandin F2α, interferon γ and tumor necrosis factor α.
  3. These results suggest that polymorphism of the TNFalpha-824 A>G gene and mTNFalpha protein expression play an important role in the pathogenesis of enzootic bovine leukosis.
    Title: Tumor necrosis factor-alpha (TNFα) gene polymorphism and expression of membrane-bound TNFα protein on CD11b+ and IgM+ cells in cows naturally infected with bovine leukemia virus.
  4. These results suggest that the endometrium might lower the TNF concentration in the blastocyst by (1) regulating TNF secretion into the uterine fluid and (2) inducing decreased TNF and TNFR2 mRNA transcription in the embryo.
    Title: Early embryonic and endometrial regulation of tumor necrosis factor and tumor necrosis factor receptor 2 in the cattle uterus.
  5. There was a significant association between the proviral load and a low frequency of the G/G genotype of TNF-alpha at position -824.
    Title: Association of TNF-α gene promoter region polymorphisms in bovine leukemia virus (BLV)-infected cattle with different proviral loads.
  6. SNP in the TNF-alpha gene affects immune function and reproductive performance in dairy cows.
    Title: The effect of single nucleotide polymorphisms in the tumor necrosis factor-α gene on reproductive performance and immune function in dairy cattle.
  7. Studied genotypic and expression profiling of partial TNF-alpha gene and its association with mastitis susceptibility in 129 crossbred cattle.
    Title: Association and expression analysis of single nucleotide polymorphisms of partial tumor necrosis factor alpha gene with mastitis in crossbred cattle.
  8. Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.
    Title: Different expression of PGE synthase, PGF receptor, TNF, Fas and oxytocin in the bovine corpus luteum of the estrous cycle and pregnancy.
  9. TNF-alpha up-regulates NaV1.7 mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha
    Title: Up-regulation of NaV1.7 sodium channels expression by tumor necrosis factor-α in cultured bovine adrenal chromaffin cells and rat dorsal root ganglion neurons.
  10. These results provide evidence for a high prevalence of subclinical endometritis in repeat breeding cows as well as the involvement of TNFalpha and iNOS pathways in the regulation of this pathological condition.
    Title: Prevalence of subclinical endometritis in repeat breeding cows and mRNA expression of tumor necrosis factor alpha and inducible nitric oxide synthase in the endometrium of repeat breeding cows with and without subclinical endometritis.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
tumor necrosis factor
Names
cachectin
tumor necrosis factor alpha
tumor necrosis factor ligand superfamily member 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173966.3 → NP_776391.2  tumor necrosis factor

    See identical proteins and their annotated locations for NP_776391.2

    Status: PROVISIONAL

    Source sequence(s)
    BC134755
    UniProtKB/Swiss-Prot
    A4IFT5, A9QWR7, O18779, Q06599, Q27978
    UniProtKB/TrEMBL
    G5DDB3
    Conserved Domains (1) summary
    pfam00229
    Location:103 → 234
    TNF; TNF(tumor Necrosis Factor) family

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    27716170..27718943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005223596.5 → XP_005223653.4  tumor necrosis factor isoform X1

    UniProtKB/TrEMBL
    G5DDB3
    Conserved Domains (1) summary
    pfam00229
    Location:102 → 233
    TNF; TNF(tumor Necrosis Factor) family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06599.2 GenPept UniProtKB/Swiss-Prot:Q06599

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials