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TIE1 tyrosine kinase with immunoglobulin like and EGF like domains 1 [ Bos taurus (domestic cattle) ]

Gene ID: 280941, updated on 5-Sep-2025
Official Symbol
TIE1provided by VGNC
Official Full Name
tyrosine kinase with immunoglobulin like and EGF like domains 1provided by VGNC
Primary source
VGNC:VGNC:35861
See related
BGD:BT11866; EnsemblRapid:ENSBTAG00070004150
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
TIE
Orthologs
all
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Try the new Transcripts and proteins table
See TIE1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (102694836..102714367, complement)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene cell division cycle 20 Neighboring gene U6 spliceosomal RNA Neighboring gene MPL proto-oncogene, thrombopoietin receptor Neighboring gene hypoxanthine-guanine phosphoribosyltransferase Neighboring gene chromosome 3 C1orf210 homolog Neighboring gene transmembrane protein 125

Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. Sato TN, et al. Proc Natl Acad Sci U S A, 1993 Oct 15. PMID 8415706, Free PMC Article
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
tyrosine-protein kinase receptor Tie-1
Names
tyrosine kinase with immunoglobulin and epidermal growth factor homology domains
NP_776390.1

Length

  • 1136

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173965.2 → NP_776390.1  tyrosine-protein kinase receptor Tie-1 precursor

    See identical proteins and their annotated locations for NP_776390.1

    Status: PROVISIONAL

    Source sequence(s)
    X71423
    UniProtKB/Swiss-Prot
    Q06805
    UniProtKB/TrEMBL
    F1MX81
    Related
    ENSBTAP00070005265.1, ENSBTAT00070009401.1
    Conserved Domains (6) summary
    smart00219
    Location:837 → 1105
    TyrKc; Tyrosine kinase, catalytic domain
    cd00054
    Location:225 → 254
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00063
    Location:642 → 734
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:546 → 630
    fn3; Fibronectin type III domain
    pfam00047
    Location:127 → 208
    ig; Immunoglobulin domain
    cl21453
    Location:834 → 1130
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    102694836..102714367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06805.1 GenPept UniProtKB/Swiss-Prot:Q06805

Gene LinkOut

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Molecular Biology Databases
Research Materials