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NNT nicotinamide nucleotide transhydrogenase [ Bos taurus (domestic cattle) ]

Gene ID: 280878, updated on 4-Oct-2024

Summary

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Official Symbol
NNTprovided by VGNC
Official Full Name
nicotinamide nucleotide transhydrogenaseprovided by VGNC
Primary source
VGNC:VGNC:32143
See related
BGD:BT11461; Ensembl:ENSBTAG00000011885
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See NNT in Genome Data Viewer
Location:
chromosome: 20
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (31153166..31245465, complement)

Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene histone H2B type 1-C/E/F/G/I Neighboring gene phosphoglycerate mutase 1-like Neighboring gene uncharacterized LOC132343229 Neighboring gene poly(A) binding protein interacting protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of transhydrogenase domain III at 1.2 A resolution. Prasad GS, et al. Nat Struct Biol, 1999 Dec. PMID 10581554
  2. Amino acid sequence of the NAD (H)--binding region of the mitochondrial nicotinamide nucleotide transhydrogenase modified by N,N'-dicyclohexylcarbodiimide. Wakabayashi S, et al. Biochem Int, 1987 Sep. PMID 3426633
  3. Characterization of the substrate-binding sites of the mitochondrial nicotinamide nucleotide transhydrogenase. Wakabayashi S, et al. Biochem Int, 1987 Nov. PMID 3325062
  4. The primary structure of the mitochondrial energy-linked nicotinamide nucleotide transhydrogenase deduced from the sequence of cDNA clones. Yamaguchi M, et al. J Biol Chem, 1988 Feb 25. PMID 3277960
  5. Amino acid sequence of the signal peptide of mitochondrial nicotinamide nucleotide transhydrogenase as determined from the sequence of its messenger RNA. Yamaguchi M, et al. Biochem Biophys Res Commun, 1988 Nov 30. PMID 3196335

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in NADPH regeneration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
NAD(P) transhydrogenase, mitochondrial
Names
pyridine nucleotide transhydrogenase
NP_776368.1
XP_005221585.1
XP_005221586.1
XP_005221587.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173943.3 → NP_776368.1  NAD(P) transhydrogenase, mitochondrial precursor

    Status: PROVISIONAL

    Source sequence(s)
    J03534
    UniProtKB/Swiss-Prot
    A4FUB4, P11024
    UniProtKB/TrEMBL
    A0AAF7AQ35
    Related
    ENSBTAP00000015769.2, ENSBTAT00000015769.4
    Conserved Domains (2) summary
    PRK09424
    Location:57 → 587
    pntA; NAD(P) transhydrogenase subunit alpha; Provisional
    pfam02233
    Location:622 → 1079
    PNTB; NAD(P) transhydrogenase beta subunit

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    31153166..31245465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005221530.5 → XP_005221587.1  NAD(P) transhydrogenase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    A4FUB4, P11024
    UniProtKB/TrEMBL
    A0AAF7AQ35
    Conserved Domains (2) summary
    PRK09424
    Location:57 → 587
    pntA; NAD(P) transhydrogenase subunit alpha; Provisional
    pfam02233
    Location:622 → 1079
    PNTB; NAD(P) transhydrogenase beta subunit

  2. XM_005221529.5 → XP_005221586.1  NAD(P) transhydrogenase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    A4FUB4, P11024
    UniProtKB/TrEMBL
    A0AAF7AQ35
    Related
    ENSBTAP00000076166.1, ENSBTAT00000122082.1
    Conserved Domains (2) summary
    PRK09424
    Location:57 → 587
    pntA; NAD(P) transhydrogenase subunit alpha; Provisional
    pfam02233
    Location:622 → 1079
    PNTB; NAD(P) transhydrogenase beta subunit

  3. XM_005221528.5 → XP_005221585.1  NAD(P) transhydrogenase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    A4FUB4, P11024
    UniProtKB/TrEMBL
    A0AAF7AQ35
    Conserved Domains (2) summary
    PRK09424
    Location:57 → 587
    pntA; NAD(P) transhydrogenase subunit alpha; Provisional
    pfam02233
    Location:622 → 1079
    PNTB; NAD(P) transhydrogenase beta subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11024.3 GenPept UniProtKB/Swiss-Prot:P11024

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