MTR 5-methyltetrahydrofolate-homocysteine methyltransferase [Bos taurus (cattle)] - Gene

Summary

Official Symbol: MTRprovided by VGNC
Official Full Name: 5-methyltetrahydrofolate-homocysteine methyltransferaseprovided by VGNC
Primary source: VGNC:VGNC:31749
See related: BGD:BT23506; Ensembl:ENSBTAG00000012251
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 28

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	28	NC_037355.1 (9420582..9552895)

Chromosome 28 - NC_037355.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings indicate that greater synthesis of phosphatidylcholine and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.
Title: Hepatic Activity and Transcription of Betaine-Homocysteine Methyltransferase, Methionine Synthase, and Cystathionine Synthase in Periparturient Dairy Cows Are Altered to Different Extents by Supply of Methionine and Choline.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cobalamin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables methionine synthase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in methionine biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in pteridine-containing compound metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: methionine synthase

Names: MS; cobalamin-dependent methionine synthase; vitamin-B12 dependent methionine synthase

NP_001025469.1

EC 2.1.1.13

XP_010818713.1

EC 2.1.1.13

XP_024842271.1

EC 2.1.1.13

XP_059738391.1

EC 2.1.1.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030298.1 → NP_001025469.1 methionine synthase

See identical proteins and their annotated locations for NP_001025469.1

Status: PROVISIONAL

Source sequence(s)

DQ084519

UniProtKB/Swiss-Prot

Q4JIJ3

UniProtKB/TrEMBL

A0A3Q1M346

Related

ENSBTAP00000067894.2, ENSBTAT00000082214.2

Conserved Domains (5) summary

COG0646
Location:21 → 340

MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]

PRK09490
Location:14 → 1261

metH; B12-dependent methionine synthase; Provisional

cd00740
Location:371 → 627

MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...

cd02069
Location:671 → 897

methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).

pfam02965
Location:965 → 1246

Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

Range

9420582..9552895

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_010820411.4 → XP_010818713.1 methionine synthase isoform X1

UniProtKB/TrEMBL

A0A3Q1M346

Related

ENSBTAP00000069537.2, ENSBTAT00000080747.2

Conserved Domains (5) summary

COG0646
Location:20 → 339

MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]

PRK09490
Location:13 → 1260

metH; B12-dependent methionine synthase; Provisional

cd00740
Location:370 → 626

MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...

cd02069
Location:670 → 896

methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).

pfam02965
Location:964 → 1245

Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain
XM_024986503.2 → XP_024842271.1 methionine synthase isoform X2

UniProtKB/TrEMBL

A0A3Q1MEQ8

Conserved Domains (1) summary

cl22882
Location:1 → 995

S-methyl_trans; Homocysteine S-methyltransferase
XM_059882408.1 → XP_059738391.1 methionine synthase isoform X3