MTTP microsomal triglyceride transfer protein [Bos taurus (cattle)] - Gene

Summary

Official Symbol: MTTPprovided by VGNC
Official Full Name: microsomal triglyceride transfer proteinprovided by VGNC
Primary source: VGNC:VGNC:31754
See related: BGD:BT27331; Ensembl:ENSBTAG00000011944
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: MTP
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	ARS-UCD1.2 (GCF_002263795.1)	6	NC_037333.1 (25005876..25062589, complement)
105	previous assembly	Bos_taurus_UMD_3.1.1 (GCF_000003055.6)	6	AC_000163.1 (26405093..26433473, complement) , (26376148..26401627, complement)

Chromosome 6 - NC_037333.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nonesterified fatty acids significantly inhibit the expression of ApoB100, ApoE, MTP, and LDLR, thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Title: Effects of nonesterified fatty acids on the synthesis and assembly of very low density lipoprotein in bovine hepatocytes in vitro.
measurements of the transfer of phospholipids (PLs) and cholesteryl esters (CEs)to acceptor vesicles by purified MTP showed TAG transfer activity was the most robust, and CE and PL transfer activities were 60-71% and 5-13% of the TAG transfer activity
Title: Transfer of cholesteryl esters and phospholipids as well as net deposition by microsomal triglyceride transfer protein.
after calving the apolipoprotein B(100) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP) and apolipoprotein E messenger RNA abundance were higher in the liver
Title: Abundance of mRNA of apolipoprotein b100, apolipoprotein e, and microsomal triglyceride transfer protein in liver from periparturient dairy cows.

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General gene information

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Homology

Homologs of the MTTP gene: The MTTP gene is conserved in human, chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 491 organisms have orthologs with human gene MTTP
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ceramide 1-phosphate transfer activity	ISS Inferred from Sequence or Structural Similarity more info
enables cholesterol transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylethanolamine transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables triglyceride transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables triglyceride transfer activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in ceramide 1-phosphate transport	IEA Inferred from Electronic Annotation more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in phospholipid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma lipoprotein particle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in sterol transport	IEA Inferred from Electronic Annotation more info
involved_in triglyceride transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: microsomal triglyceride transfer protein large subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.