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MDK midkine [ Bos taurus (domestic cattle) ]

Gene ID: 280852, updated on 5-Sep-2025
Official Symbol
MDKprovided by VGNC
Official Full Name
midkineprovided by VGNC
Primary source
VGNC:VGNC:49556
See related
BGD:BT19041; EnsemblRapid:ENSBTAG00070030685
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See MDK in Genome Data Viewer
Location:
chromosome: 15
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (76374892..76377926)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132342366 Neighboring gene cAMP responsive element binding protein 3 like 1 Neighboring gene diacylglycerol kinase zeta Neighboring gene cholinergic receptor muscarinic 4 Neighboring gene autophagy and beclin 1 regulator 1 Neighboring gene transcription initiation factor TFIID subunit 9-like Neighboring gene harbinger transposase derived 1

Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. cDNA cloning of bovine midkine and production of the recombinant protein, which affects in vitro maturation of bovine oocytes. Ikeda S, et al. Mol Reprod Dev, 2000 Sep. PMID 10954861
  2. 9-cis-retinoic acid during in vitro maturation improves development of the bovine oocyte and increases midkine but not IGF-I expression in cumulus-granulosa cells. Gómez E, et al. Mol Reprod Dev, 2003 Nov. PMID 14502603
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that 9-cis-retinoic acid enhanced midkine gene expression, but not insulin-like growth factor-I gene expression, in cumulus-granulosa cells.
    Title: 9-cis-retinoic acid during in vitro maturation improves development of the bovine oocyte and increases midkine but not IGF-I expression in cumulus-granulosa cells.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
midkine
Names
midkine (neurite growth-promoting factor 2)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173935.3 → NP_776360.2  midkine precursor

    See identical proteins and their annotated locations for NP_776360.2

    Status: PROVISIONAL

    Source sequence(s)
    BC103211
    UniProtKB/TrEMBL
    A0A3Q1LZZ7, Q3SZ28
    Related
    ENSBTAP00070042293.1, ENSBTAT00070069439.1
    Conserved Domains (1) summary
    smart00193
    Location:37 → 116
    PTN; Pleiotrophin / midkine family

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    76374892..76377926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005216402.5 → XP_005216459.1  midkine isoform X1

    UniProtKB/TrEMBL
    F6RZG1
    Related
    ENSBTAP00070042310.1, ENSBTAT00070069470.1
    Conserved Domains (1) summary
    smart00193
    Location:46 → 125
    PTN; Pleiotrophin / midkine family

  2. XM_005216404.5 → XP_005216461.1  midkine isoform X2

    See identical proteins and their annotated locations for XP_005216461.1

    UniProtKB/TrEMBL
    A0A3Q1LZZ7, Q9N0E6
    Conserved Domains (1) summary
    smart00193
    Location:37 → 116
    PTN; Pleiotrophin / midkine family

  3. XM_005216403.5 → XP_005216460.1  midkine isoform X2

    See identical proteins and their annotated locations for XP_005216460.1

    UniProtKB/TrEMBL
    A0A3Q1LZZ7, Q9N0E6
    Conserved Domains (1) summary
    smart00193
    Location:37 → 116
    PTN; Pleiotrophin / midkine family
Nucleotide Protein Strain
Heading Accession and Version

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