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LIF LIF interleukin 6 family cytokine [ Bos taurus (domestic cattle) ]

Gene ID: 280840, updated on 5-Sep-2025
Official Symbol
LIFprovided by VGNC
Official Full Name
LIF interleukin 6 family cytokineprovided by VGNC
Primary source
VGNC:VGNC:30880
See related
BGD:BT16756
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See LIF in Genome Data Viewer
Location:
chromosome: 17
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (69262879..69267183, complement)

Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 3 Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene HORMA domain containing 2 Neighboring gene cytosolic arginine sensor for mTORC1 subunit 1 Neighboring gene oncostatin M

Genomic Sequence:
NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Leukemia inhibitory factor enhances bovine oocyte maturation and early embryo development. Mo X, et al. Mol Reprod Dev, 2014 Jul. PMID 24687528
  2. Gene expression of leukemia inhibitory factor (LIF) and macrophage colony stimulating factor (M-CSF) in bovine endometrium during early pregnancy. Oshima K, et al. Theriogenology, 2003 Oct 15. PMID 14511776
  3. Genetic characterization of the bovine leukaemia inhibitory factor (LIF) gene: isolation and sequencing, chromosome assignment and microsatellite analysis. Piedrahita JA, et al. Anim Genet, 1997 Feb. PMID 9124702
  4. LIF regulates the expression of miR-27a-3p and HOXA10 in bovine endometrial epithelial cells via STAT3 pathway. Li Q, et al. Theriogenology, 2023 Oct 15. PMID 37490795
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LIF regulates the expression of miR-27a-3p and HOXA10 in bovine endometrial epithelial cells via STAT3 pathway.
    Title: LIF regulates the expression of miR-27a-3p and HOXA10 in bovine endometrial epithelial cells via STAT3 pathway.
  2. Studied the effects of leukemia inhibitory factor (LIF) on bovine oocyte maturation and early embryo development in vitro.
    Title: Leukemia inhibitory factor enhances bovine oocyte maturation and early embryo development.
  3. results suggest that leukemia inhibitory factor and macrophage-colony stimulating factor are produced in the endometrium and may play different roles in early and mid-pregnancy
    Title: Gene expression of leukemia inhibitory factor (LIF) and macrophage colony stimulating factor (M-CSF) in bovine endometrium during early pregnancy.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables leukemia inhibitory factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in leukemia inhibitory factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
leukemia inhibitory factor
Names
bLIF
cholinergic differentiation factor
leukemia inhibitory factor (cholinergic differentiation factor)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173931.1 → NP_776356.1  leukemia inhibitory factor precursor

    See identical proteins and their annotated locations for NP_776356.1

    Status: PROVISIONAL

    Source sequence(s)
    U65394
    UniProtKB/Swiss-Prot
    Q27956
    Conserved Domains (1) summary
    smart00080
    Location:34 → 191
    LIF_OSM; leukemia inhibitory factor

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    69262879..69267183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q27956.1 GenPept UniProtKB/Swiss-Prot:Q27956

Gene LinkOut

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