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Vps25 vacuolar protein sorting 25 [ Mus musculus (house mouse) ]

Gene ID: 28084, updated on 12-May-2024

Summary

Official Symbol
Vps25provided by MGI
Official Full Name
vacuolar protein sorting 25provided by MGI
Primary source
MGI:MGI:106354
See related
Ensembl:ENSMUSG00000078656 AllianceGenome:MGI:106354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D11Wsu68e; 1110020N13Rik
Summary
Predicted to enable protein N-terminus binding activity; protein homodimerization activity; and structural molecule activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity and protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to act upstream of or within protein transport. Located in mitochondrion. Is expressed in several structures, including central nervous system; extraembryonic component; and lung. Orthologous to human VPS25 (vacuolar protein sorting 25 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 27.4), genital fat pad adult (RPKM 25.6) and 28 other tissues See more
Orthologs
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Genomic context

See Vps25 in Genome Data Viewer
Location:
11 D; 11 64.48 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101144533..101150377)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101252326..101259551)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene enhancer of zeste 1 polycomb repressive complex 2 subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:101110062-101110171 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:101114923-101115106 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:101115117-101115300 Neighboring gene receptor (calcitonin) activity modifying protein 2 Neighboring gene WNK lysine deficient protein kinase 4 Neighboring gene cytochrome C oxidase assembly factor 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of ESCRT II complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ESCRT II complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
vacuolar protein-sorting-associated protein 25
Names
ESCRT-II complex subunit VPS25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284411.2NP_001271340.1  vacuolar protein-sorting-associated protein 25 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK150822, AL590969
    Consensus CDS
    CCDS70311.1
    UniProtKB/TrEMBL
    A2A4J8
    Related
    ENSMUSP00000102901.5, ENSMUST00000107280.11
    Conserved Domains (1) summary
    pfam05871
    Location:10153
    ESCRT-II; ESCRT-II complex subunit
  2. NM_001284412.2NP_001271341.1  vacuolar protein-sorting-associated protein 25 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK082933, AL590969
    Consensus CDS
    CCDS70313.1
    UniProtKB/TrEMBL
    A2A4K0
    Related
    ENSMUSP00000097981.6, ENSMUST00000100414.12
    Conserved Domains (1) summary
    pfam05871
    Location:10142
    ESCRT-II; ESCRT-II complex subunit
  3. NM_001284414.1NP_001271343.1  vacuolar protein-sorting-associated protein 25 isoform 4

    See identical proteins and their annotated locations for NP_001271343.1

    Status: VALIDATED

    Source sequence(s)
    AK003877, AK150822, AL590969
    Consensus CDS
    CCDS70312.1
    UniProtKB/Swiss-Prot
    Q9CQ80
    Related
    ENSMUSP00000007533.9, ENSMUST00000007533.15
    Conserved Domains (1) summary
    pfam05871
    Location:10139
    ESCRT-II; ESCRT-II complex subunit
  4. NM_026776.5NP_081052.2  vacuolar protein-sorting-associated protein 25 isoform 2

    See identical proteins and their annotated locations for NP_081052.2

    Status: VALIDATED

    Source sequence(s)
    AK150822, AL590969
    Consensus CDS
    CCDS25458.1
    UniProtKB/Swiss-Prot
    A2A4J9, A2A4K1, Q3UBT0, Q9CQ80, Q9D167
    Related
    ENSMUSP00000042088.7, ENSMUST00000042477.13
    Conserved Domains (1) summary
    pfam05871
    Location:10139
    ESCRT-II; ESCRT-II complex subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    101144533..101150377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)