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EVC2 EvC ciliary complex subunit 2 [ Bos taurus (domestic cattle) ]

Gene ID: 280834, updated on 30-Jan-2025
Official Symbol
EVC2provided by VGNC
Official Full Name
EvC ciliary complex subunit 2provided by VGNC
Primary source
VGNC:VGNC:28635
See related
BGD:BT18849; EnsemblRapid:ENSBTAG00070026118
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
LBN
Orthologs
human mouse all
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See EVC2 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (103497473..103662789)

Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132345544 Neighboring gene collapsin response mediator protein 1 Neighboring gene EvC ciliary complex subunit 1 Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene serine/threonine kinase 32B Neighboring gene transfer RNA cysteine (anticodon ACA)

Genomic Sequence:
NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Deletion in the EVC2 gene causes chondrodysplastic dwarfism in Tyrolean Grey cattle. Murgiano L, et al. PLoS One, 2014. PMID 24733244, Free PMC Article
  2. Positional cloning of the gene LIMBIN responsible for bovine chondrodysplastic dwarfism. Takeda H, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12136126, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in ciliary membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of plasma membrane protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
limbin
Names
Ellis van Creveld syndrome 2 (limbin)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173927.1 → NP_776352.1  limbin

    See identical proteins and their annotated locations for NP_776352.1

    Status: PROVISIONAL

    Source sequence(s)
    AB083065
    UniProtKB/Swiss-Prot
    Q8MI28
    UniProtKB/TrEMBL
    A0AAA9THK4
    Conserved Domains (2) summary
    pfam12297
    Location:137 → 560
    EVC2_like; Ellis van Creveld protein 2 like protein
    cl25732
    Location:384 → 1009
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    103497473..103662789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024992973.2 → XP_024848741.1  limbin isoform X2

    UniProtKB/Swiss-Prot
    Q8MI28
    UniProtKB/TrEMBL
    A0AAA9THK4
    Conserved Domains (2) summary
    pfam12297
    Location:137 → 560
    EVC2_like; Ellis van Creveld protein 2 like protein
    cl25732
    Location:384 → 1009
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_024992972.2 → XP_024848740.1  limbin isoform X1

    UniProtKB/TrEMBL
    A0AAA9THK4, E1BES3
    Related
    ENSBTAP00070035080.1, ENSBTAT00070059145.1
    Conserved Domains (2) summary
    pfam12297
    Location:228 → 651
    EVC2_like; Ellis van Creveld protein 2 like protein
    cl25732
    Location:475 → 1100
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_024992975.2 → XP_024848743.1  limbin isoform X2

    UniProtKB/Swiss-Prot
    Q8MI28
    UniProtKB/TrEMBL
    A0AAA9THK4
    Conserved Domains (2) summary
    pfam12297
    Location:137 → 560
    EVC2_like; Ellis van Creveld protein 2 like protein
    cl25732
    Location:384 → 1009
    SMC_N; RecF/RecN/SMC N terminal domain

  4. XM_024992974.2 → XP_024848742.1  limbin isoform X2

    UniProtKB/Swiss-Prot
    Q8MI28
    UniProtKB/TrEMBL
    A0AAA9THK4
    Conserved Domains (2) summary
    pfam12297
    Location:137 → 560
    EVC2_like; Ellis van Creveld protein 2 like protein
    cl25732
    Location:384 → 1009
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MI28.1 GenPept UniProtKB/Swiss-Prot:Q8MI28

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