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JUN Jun proto-oncogene, AP-1 transcription factor subunit [ Bos taurus (domestic cattle) ]

Gene ID: 280831, updated on 5-Sep-2025
Official Symbol
JUNprovided by VGNC
Official Full Name
Jun proto-oncogene, AP-1 transcription factor subunitprovided by VGNC
Primary source
VGNC:VGNC:30386
See related
BGD:BT10059
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See JUN in Genome Data Viewer
Location:
chromosome: 3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (87265962..87268009)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene uncharacterized LOC100294994 Neighboring gene microRNA mir-12043 Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene Myb like, SWIRM and MPN domains 1

Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. β-cantenin is potentially involved in the regulation of c-Jun signaling following bovine herpesvirus 1 infection. Chang L, et al. Vet Microbiol, 2020 Sep. PMID 32827927, Free PMC Article
  2. Signal transduction pathways involving p38 MAPK, JNK, NFkappaB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1beta and dynamic compression. Chowdhury TT, et al. Inflamm Res, 2008 Jul. PMID 18545934
  3. Bovine dialyzable leukocyte extract modulates AP-1 DNA-binding activity and nuclear transcription factor expression in MCF-7 breast cancer cells. Mendoza-Gamboa E, et al. Cytotherapy, 2008. PMID 18368600
  4. The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation. Ji Z, et al. Mol Cell Biol, 2012 Jan. PMID 22083952, Free PMC Article
  5. Mechanisms of endothelial response to oxidative aggression: protective role of autologous VEGF and induction of VEGFR2 by H2O2. González-Pacheco FR, et al. Am J Physiol Heart Circ Physiol, 2006 Sep. PMID 16899768

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. beta-cantenin is potentially involved in the regulation of c-Jun signaling following bovine herpesvirus 1 infection.
    Title: β-cantenin is potentially involved in the regulation of c-Jun signaling following bovine herpesvirus 1 infection.
  2. The present data indicate that bovine dialyzable leukocyte extract can block the AP-1 DNA-binding activity and expression of several transcriptions factors in breast cancer cells.
    Title: Bovine dialyzable leukocyte extract modulates AP-1 DNA-binding activity and nuclear transcription factor expression in MCF-7 breast cancer cells.
  3. dynamic compression stimulates cell proliferation and proteoglycan synthesis in the presence of IL-1beta and/or inhibitors of the MAPKs and NFkappaB and AP-1 signalling pathways
    Title: Signal transduction pathways involving p38 MAPK, JNK, NFkappaB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1beta and dynamic compression.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
transcription factor Jun
Names
AP1
activator protein 1
jun oncogene
proto-oncogene c-jun
transcription factor AP-1
transcription factor AP-1 subunit Jun
v-jun avian sarcoma virus 17 oncogene homolog

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077827.1 → NP_001071295.1  transcription factor Jun

    See identical proteins and their annotated locations for NP_001071295.1

    Status: PROVISIONAL

    Source sequence(s)
    BC123753
    UniProtKB/TrEMBL
    Q08DH1
    Conserved Domains (2) summary
    cd14696
    Location:226 → 286
    bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
    pfam03957
    Location:5 → 213
    Jun; Jun-like transcription factor

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    87265962..87268009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77627.2 GenPept UniProtKB/Swiss-Prot:O77627

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.