GHR growth hormone receptor [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: GHRprovided by VGNC
Official Full Name: growth hormone receptorprovided by VGNC
Primary source: VGNC:VGNC:50184
See related: BGD:BT10760; EnsemblRapid:ENSBTAG00070007338
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	20	NC_037347.1 (31869704..32043372, complement)

Chromosome 20 - NC_037347.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study showed that the IGF-1 SnaBI TT appears to be associated with fewer days to ovulation and lesser calving to conseption interval of lactating dairy cows and had an additive association with the GHR AluI T allele on indicators for improvement of fertility.
Title: Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows.
rs41639262 associated with fertility in hot-humid climate
Title: Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate.
Most heifer reproductive traits were not significantly affected by CAST and CAPN1 markers that are widely used to improve beef tenderness by selection and breeders should not be concerned with how these markers affect reproduction and other heifer traits with the possible exception of CAPN1 effects on calving date.
Title: μ-Calpain (CAPN1), calpastatin (CAST), and growth hormone receptor (GHR) genetic effects on Angus beef heifer performance traits and reproduction.
There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.
Title: Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows.
hepatic growth hormone receptor and suppressor of cytokine signaling (SOCS)2 messenger RNA expression appeared to be promptly and sensitively regulated by increased estradiol levels before ovulation of dairy heifers
Title: The somatotropic axis during the physiological estrus cycle in dairy heifers--Effect on hepatic expression of GHR and SOCS2.
Comparatively studied genetic diversity of growth hormone receptor (GHR) in Tibetan cattle and Chinese Holstein cow.
Title: Comparative Study on the Genetic Diversity of GHR Gene in Tibetan Cattle and Holstein Cows.
This work confirms the importance of CAPN1 and CAST for tenderness in beef, provides a new effect of CAST on beef tenderness, and questions the utility of GHR as a selection marker for beef quality.
Title: μ-Calpain, calpastatin, and growth hormone receptor genetic effects on preweaning performance, carcass quality traits, and residual variance of tenderness in Angus cattle selected to increase minor haplotype and allele frequencies.
the data support the high potential of the growth hormone receptor F279Y polymorphism as a marker for the improvement of milk traits in selection programs
Title: The F279Y polymorphism of the GHR gene and its relation to milk production and somatic cell score in German Holstein dairy cattle.
6 of the published GHR SNPs and 7 of the novel GHR SNPs were associated with at least 1 of the traits--milk yield, fat yield, protein yield, fat percentage, protein percentage, somatic cell score, calving interval, survival and growth and size traits.
Title: Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle.
Effects of GHR p.Phe279Tyr mutations on milk, fat and protein yield, as well as fat and protein percentage in the milk of 1222 Holstein cows was found to be significantly associated with protein percentage.
Title: Effects of DGAT1 and GHR on milk yield and milk composition in the Chinese dairy population.

Submit: New GeneRIF Correction See all GeneRIFs (23)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine binding	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables growth hormone receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in growth hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of growth hormone receptor complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: growth hormone receptor

Names: GH receptor; somatotropin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176608.1 → NP_788781.1 growth hormone receptor precursor

See identical proteins and their annotated locations for NP_788781.1

Status: PROVISIONAL

Source sequence(s)

AF044258

UniProtKB/Swiss-Prot

O46600, O77538, Q5XM78, Q9TQV9, Q9TUY7

Related

ENSBTAP00070009684.1, ENSBTAT00070016704.1

Conserved Domains (3) summary

cd00063
Location:145 → 246

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12772
Location:312 → 613

GHBP; Growth hormone receptor binding

cl21522
Location:49 → 123

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...