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FOS Fos proto-oncogene, AP-1 transcription factor subunit [ Bos taurus (domestic cattle) ]

Gene ID: 280795, updated on 5-Sep-2025
Official Symbol
FOSprovided by VGNC
Official Full Name
Fos proto-oncogene, AP-1 transcription factor subunitprovided by VGNC
Primary source
VGNC:VGNC:29073
See related
BGD:BT11906; EnsemblRapid:ENSBTAG00070021881
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See FOS in Genome Data Viewer
Location:
chromosome: 10
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (86488949..86492375)

Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene NIMA related kinase 9 Neighboring gene transmembrane p24 trafficking protein 10 Neighboring gene uncharacterized LOC112448568 Neighboring gene glutamate-ammonia ligase (glutamine synthetase) pseudogene

Genomic Sequence:
NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. c-Fos mediates angiotensin II-induced aldosterone production and protein synthesis in bovine adrenal glomerulosa cells. Rincon Garriz JM, et al. Endocrinology, 2009 Mar. PMID 18974265
  2. NCAPG Dynamically Coordinates the Myogenesis of Fetal Bovine Tissue by Adjusting Chromatin Accessibility. Hu X, et al. Int J Mol Sci, 2020 Feb 13. PMID 32070024, Free PMC Article
  3. Bovine dialyzable leukocyte extract modulates AP-1 DNA-binding activity and nuclear transcription factor expression in MCF-7 breast cancer cells. Mendoza-Gamboa E, et al. Cytotherapy, 2008. PMID 18368600
  4. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  5. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NCAPG Dynamically Coordinates the Myogenesis of Fetal Bovine Tissue by Adjusting Chromatin Accessibility.
    Title: NCAPG Dynamically Coordinates the Myogenesis of Fetal Bovine Tissue by Adjusting Chromatin Accessibility.
  2. The present data indicate that bovine dialyzable leukocyte extract can block the AP-1 DNA-binding activity and expression of several transcriptions factors in breast cancer cells.
    Title: Bovine dialyzable leukocyte extract modulates AP-1 DNA-binding activity and nuclear transcription factor expression in MCF-7 breast cancer cells.
  3. c-Fos/c-Jun complex binds to the proximal StAR promoter in glomerulosa cells, thus activating StAR gene expression and acute aldosterone biosynthesis.
    Title: c-Fos mediates angiotensin II-induced aldosterone production and protein synthesis in bovine adrenal glomerulosa cells.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC139881

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
protein c-Fos
Names
cellular oncogene fos
proto-oncogene c-Fos
proto-oncogene protein c-fos
transcription factor AP-1 subunit c-Fos

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182786.2 → NP_877587.1  protein c-Fos

    See identical proteins and their annotated locations for NP_877587.1

    Status: PROVISIONAL

    Source sequence(s)
    BC118280
    UniProtKB/Swiss-Prot
    A1L550, O77628, Q17QM0, Q7YRP7
    UniProtKB/TrEMBL
    A0AAA9TRB6
    Related
    ENSBTAP00070029300.1, ENSBTAT00070049281.1
    Conserved Domains (1) summary
    cd14721
    Location:147 → 200
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    86488949..86492375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77628.2 GenPept UniProtKB/Swiss-Prot:O77628

Gene LinkOut

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