Desi1 desumoylating isopeptidase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Desi1provided by MGI
Official Full Name: desumoylating isopeptidase 1provided by MGI
Primary source: MGI:MGI:106313
See related: Ensembl:ENSMUSG00000022472 AllianceGenome:MGI:106313
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DeSI-1; Pppde2; Fam152b; D15Wsu75e
Summary: Enables SUMO-specific isopeptidase activity and identical protein binding activity. Involved in protein desumoylation. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Is expressed in extraembryonic component. Orthologous to human DESI1 (desumoylating isopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 105.5), thymus adult (RPKM 62.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 38.34 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (81876724..81900424, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (81992523..82016258, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A new deSUMOylase named DeSI-1 (DeSumoylating Isopeptidase 1), was identified.
Title: DeSUMOylating isopeptidase: a second class of SUMO protease.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487780

RH124905 (e-PCR)
- UniSTS:161727

PMC307632P1 (e-PCR)
- UniSTS:272583

RH125897 (e-PCR)
- UniSTS:142031

AI427858 (e-PCR)
- UniSTS:160488

AI850401 (e-PCR)
- UniSTS:164586

Homology

Homologs of the Desi1 gene: The Desi1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, M.oryzae, N.crassa, and frog.
Orthologs from Annotation Pipeline: 352 organisms have orthologs with human gene Desi1

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables deSUMOylase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables importin-alpha family protein binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein desumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein modification by small protein removal	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: desumoylating isopeptidase 1

Names: PPPDE peptidase domain containing 2; PPPDE peptidase domain-containing protein 2; family with sequence similarity 152, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356541.2 → NP_001343470.1 desumoylating isopeptidase 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC102176

Conserved Domains (1) summary

pfam05903
Location:7 → 148

Peptidase_C97; PPPDE putative peptidase domain
NM_134095.4 → NP_598856.1 desumoylating isopeptidase 1 isoform 1

See identical proteins and their annotated locations for NP_598856.1

Status: VALIDATED

Source sequence(s)

AC102176

Consensus CDS

CCDS27681.1

UniProtKB/Swiss-Prot

Q3V2M9, Q9CQT7

UniProtKB/TrEMBL

A0A6P5QWC9, A0A8C6HFN0

Related

ENSMUSP00000121504.2, ENSMUST00000152227.8

Conserved Domains (1) summary

pfam05903
Location:7 → 149

Peptidase_C97; PPPDE putative peptidase domain