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BGN biglycan [ Bos taurus (domestic cattle) ]

Gene ID: 280733, updated on 8-Apr-2026
Official Symbol
BGNprovided by VGNC
Official Full Name
biglycanprovided by VGNC
Primary source
VGNC:VGNC:26481
See related
EnsemblRapid:ENSBTAG00070033292
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
all
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Try the new Transcripts and proteins table
See BGN in Genome Data Viewer
Location:
chromosome: X
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (36728478..36742281)

Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene three prime repair exonuclease 2 Neighboring gene HAUS augmin like complex subunit 7 Neighboring gene extracellular matrix protein X-linked Neighboring gene ATPase plasma membrane Ca2+ transporting 3 Neighboring gene cyclin Q

Genomic Sequence:
NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that biglycan, collagen type I, collagen type II, decorin, and versican were significantly affected by vibration duration, frequency, and amplitude.
    Title: Free axial vibrations at 0 to 200 Hz positively affect extracellular matrix messenger ribonucleic acid expression in bovine nucleus pulposi.
  2. biglycan-induced fibroblast cytoskeletal and signalling changes result in an increased cell migration; potential role in the remodelling process
    Title: Biglycan and decorin induce morphological and cytoskeletal changes involving signalling by the small GTPases RhoA and Rac1 resulting in lung fibroblast migration.
  3. biglycan showed a unique ability to organize collagen VI into extensive hexagonal-like networks over a time period of only a few minutes
    Title: Biglycan organizes collagen VI into hexagonal-like networks resembling tissue structures.
  4. The results indicate that CTGF suppresses the synthesis of biglycan but newly induced that of decorin in the cells when the cell density is low.
    Title: Differential regulation of biglycan and decorin synthesis by connective tissue growth factor in cultured vascular endothelial cells.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
biglycan
Names
PG-S1
bone/cartilage proteoglycan I
leucine-rich PG I

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178318.4 → NP_847888.2  biglycan precursor

    See identical proteins and their annotated locations for NP_847888.2

    Status: PROVISIONAL

    Source sequence(s)
    BC118460
    UniProtKB/Swiss-Prot
    P21809, P79259, Q17QB0, Q5BIM3
    UniProtKB/TrEMBL
    A0AAF6ZGY7
    Conserved Domains (3) summary
    PRK15370
    Location:65 → 298
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00031
    Location:303 → 316
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:72 → 92
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    36728478..36742281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005227658.5 → XP_005227715.1  biglycan isoform X1

    See identical proteins and their annotated locations for XP_005227715.1

    UniProtKB/Swiss-Prot
    P21809, P79259, Q17QB0, Q5BIM3
    UniProtKB/TrEMBL
    A0AAF6ZGY7
    Related
    ENSBTAP00070045848.1, ENSBTAT00070075178.1
    Conserved Domains (3) summary
    PRK15370
    Location:65 → 298
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00031
    Location:303 → 316
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:72 → 92
    LRR_RI; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21809.3 GenPept UniProtKB/Swiss-Prot:P21809

Gene LinkOut

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