ADA adenosine deaminase [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: ADAprovided by VGNC
Official Full Name: adenosine deaminaseprovided by VGNC
Primary source: VGNC:VGNC:25600
See related: BGD:BT12388; EnsemblRapid:ENSBTAG00070017865
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	13	NC_037340.1 (73028616..73052457, complement)

Chromosome 13 - NC_037340.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study concludes that dictyocaulosis alters NTPDase, 5'-nucleotidase, and ADA activities of cow naturally infected by the parasite Dictyocaulus viviparus, in consequence the enzymes act as inflammatory markers
Title: Ectonucleotidase and adenosine deaminase as inflammatory marker in dairy cows naturally infected by Dictyocaulus viviparus.
It was concluded that oxidative stress occurs in cattle experimentally infected by F. hepatica, mainly due to excessive ROS production in the course of fasciolosis, contributing to hepatic damage, and that increased in hepatic adenosine deaminase (ADA) activity may contribute to the inflammatory process.
Title: Oxidative stress and changes in adenosine deaminase activity of cattle experimentally infected by Fasciola hepatica.
Data demonstrate that dipeptidyl peptidase II can form a complex with adenosine deaminase, but with one order of magnitude higher dissociation constant than that of DPPIV.
Title: Complex of dipeptidyl peptidase II with adenosine deaminase.
This is the first report that an inhibitor molecule (EHNA) with a nucleoside framework binds to the open form of ADA and the first observation of conformational change of ADA in the crystalline state.
Title: Conformational change of adenosine deaminase during ligand-exchange in a crystal.
the transition-state structures of PfADA, HsADA, and bovine ADA (BtADA) solved using competitive kinetic isotope effects (KIE) and density functional calculations
Title: Transition-state variation in human, bovine, and Plasmodium falciparum adenosine deaminases.
Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase
Title: Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface.

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General gene information

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Markers

MARC_5031-5032:1024665472:1 (e-PCR)
- UniSTS:269438

D20S1110 (e-PCR)
- UniSTS:24021

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables adenosine deaminase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in adenosine catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hypoxanthine salvage	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inosine biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of adenosine receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in purine ribonucleoside monophosphate biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: adenosine deaminase

Names: adenosine aminohydrolase

NP_776312.1

EC 3.5.4.4

XP_024856023.2

EC 3.5.4.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.