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AR androgen receptor [ Bos taurus (domestic cattle) ]

Gene ID: 280675, updated on 30-Jan-2025
Official Symbol
ARprovided by VGNC
Official Full Name
androgen receptorprovided by VGNC
Primary source
VGNC:VGNC:26053
See related
BGD:BT11878; EnsemblRapid:ENSBTAG00070036508
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Location:
chromosome: X
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (83085618..83296076, complement)

Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene oligophrenin 1 Neighboring gene transfer RNA phenylalanine (anticodon GAA) Neighboring gene proteasome subunit alpha type-1-like Neighboring gene uncharacterized LOC112445281

Genomic Sequence:
NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Androgen receptor is widely expressed in bovine placentomes and up-regulated during differentiation of bovine trophoblast giant cells. Khatri P, et al. Placenta, 2013 May. PMID 23481223
  2. Androgen receptor CAG repeat polymorphism in prostate cancer from a Brazilian population. Santos ML, et al. Cancer Detect Prev, 2003. PMID 14585317
  3. Distinct regulation by steroids of messenger RNAs for FSHR and CYP19A1 in bovine granulosa cells. Luo W, et al. Biol Reprod, 2006 Aug. PMID 16641147
  4. Expression analysis of androgen-responsive genes in the prostate of veal calves treated with anabolic hormones. Toffolatti L, et al. Domest Anim Endocrinol, 2006 Jan. PMID 16023321
  5. Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells. Kamanga-Sollo E, et al. Domest Anim Endocrinol, 2008 Jul. PMID 18403176

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. substantial up-regulation of androgen receptor expression during trophoblast giant cell differentiation suggests that androgens may be related to this process and are active products of bovine placental steroidogenesis
    Title: Androgen receptor is widely expressed in bovine placentomes and up-regulated during differentiation of bovine trophoblast giant cells.
  2. Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.
    Title: Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.
  3. FSHR is specifically regulated through androgen receptor in granulosa cells
    Title: Distinct regulation by steroids of messenger RNAs for FSHR and CYP19A1 in bovine granulosa cells.
  4. no association between the AR CAG polymorphism and the relative risk of prostate cancer in white Brazilian individuals with a CAG repeat
    Title: Androgen receptor CAG repeat polymorphism in prostate cancer from a Brazilian population.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables estrogen response element binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in androgen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in male gonad development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
androgen receptor

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001244127.1 → NP_001231056.1  androgen receptor

    See identical proteins and their annotated locations for NP_001231056.1

    Status: VALIDATED

    Source sequence(s)
    NKLS02000030
    UniProtKB/TrEMBL
    A0A3Q1M5F4
    Related
    ENSBTAP00070049587.1, ENSBTAT00070081882.1
    Conserved Domains (3) summary
    cd07073
    Location:643 → 888
    NR_LBD_AR; Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
    cd07173
    Location:525 → 606
    NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
    pfam02166
    Location:6 → 429
    Androgen_recep; Androgen receptor

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    83085618..83296076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024987728.2 → XP_024843496.1  androgen receptor isoform X1

    UniProtKB/TrEMBL
    A0AAA9TQT7
    Related
    ENSBTAP00070049579.1, ENSBTAT00070081870.1
    Conserved Domains (2) summary
    cd07173
    Location:525 → 599
    NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
    pfam02166
    Location:6 → 429
    Androgen_recep; Androgen receptor
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials