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Adam1b a disintegrin and metallopeptidase domain 1b [ Mus musculus (house mouse) ]

Gene ID: 280667, updated on 11-Apr-2024

Summary

Official Symbol
Adam1bprovided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 1bprovided by MGI
Primary source
MGI:MGI:2429506
See related
Ensembl:ENSMUSG00000062438 AllianceGenome:MGI:2429506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ftna; Adam1
Summary
Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to be involved in binding activity of sperm to zona pellucida and male gonad development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human ADAM1B (ADAM metallopeptidase domain 1B (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See Adam1b in Genome Data Viewer
Location:
5 F; 5 61.83 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121638159..121641498, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121500096..121503435, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6373 Neighboring gene STARR-positive B cell enhancer ABC_E6374 Neighboring gene endoplasmic reticulum protein 29 Neighboring gene transmembrane protein 116 Neighboring gene STARR-positive B cell enhancer ABC_E4785 Neighboring gene mitogen-activated protein kinase 3 pseudogene Neighboring gene a disintegrin and metallopeptidase domain 1a Neighboring gene MAP kinase-activated protein kinase 5 Neighboring gene STARR-seq mESC enhancer starr_14259 Neighboring gene STARR-positive B cell enhancer ABC_E9092

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metallopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in male gonad development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in spermatogenesis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in sperm head plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 1b
Names
PH-30 alpha
a disintegrin and metalloproteinase domain 1b
fertilin alpha
fertilin subunit alpha-b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172125.3NP_742123.2  disintegrin and metalloproteinase domain-containing protein 1b precursor

    See identical proteins and their annotated locations for NP_742123.2

    Status: VALIDATED

    Source sequence(s)
    AC129215, AK016558, BB679367, BC140979
    Consensus CDS
    CCDS19636.1
    UniProtKB/Swiss-Prot
    B2RU57, Q8R534, Q9R156
    Related
    ENSMUSP00000078343.4, ENSMUST00000079368.5
    Conserved Domains (5) summary
    smart00608
    Location:489625
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:203395
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:415485
    Disintegrin; Disintegrin
    pfam01421
    Location:203397
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:63158
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    121638159..121641498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)