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WFDC10B WAP four-disulfide core domain 10B [ Homo sapiens (human) ]

Gene ID: 280664, updated on 4-Jun-2017
Official Symbol
WFDC10Bprovided by HGNC
Official Full Name
WAP four-disulfide core domain 10Bprovided by HGNC
Primary source
HGNC:HGNC:20479
See related
Ensembl:ENSG00000182931 Vega:OTTHUMG00000130227
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WAP12
Summary
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Two alternatively spliced transcript variants have been found for this gene, and they encode distinct isoforms. [provided by RefSeq, Jul 2008]
Orthologs
Location:
20q13.12
Exon count:
6
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (45684651..45708899, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44313290..44333658, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene 7 Neighboring gene WAP four-disulfide core domain 11 Neighboring gene WAP four-disulfide core domain 13 Neighboring gene microRNA 3617 Neighboring gene WAP four-disulfide core domain 3 Neighboring gene serine peptidase inhibitor, Kunitz type 4 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 3

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein WFDC10B
Names
protease inhibitor WAP12

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172006.2NP_742003.1  protein WFDC10B isoform a precursor

    See identical proteins and their annotated locations for NP_742003.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but it encodes the shorter isoform (a), which includes a signal peptide and is a secreted protein.
    Source sequence(s)
    AF454506
    Consensus CDS
    CCDS13366.1
    UniProtKB/Swiss-Prot
    Q8IUB3
    Related
    ENSP00000327628.5, OTTHUMP00000160718, ENST00000330523.9, OTTHUMT00000252547
  2. NM_172131.2NP_742143.1  protein WFDC10B isoform b

    See identical proteins and their annotated locations for NP_742143.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon and uses an upstream translation start codon, as compared to variant 1. It encodes the longer isoform (b), which lacks a signal peptide and may be an intracellular protein.
    Source sequence(s)
    AF454507
    Consensus CDS
    CCDS13365.1
    UniProtKB/Swiss-Prot
    Q8IUB3
    Related
    ENSP00000337466.2, OTTHUMP00000196689, ENST00000335769.2, OTTHUMT00000252548

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

    Range
    45684651..45708899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027824.1XP_016883313.1  protein WFDC10B isoform X1

    UniProtKB/Swiss-Prot
    Q8IUB3
  2. XM_017027825.1XP_016883314.1  protein WFDC10B isoform X1

    UniProtKB/Swiss-Prot
    Q8IUB3

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    44215982..44236349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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