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SELENOH selenoprotein H [ Homo sapiens (human) ]

Gene ID: 280636, updated on 12-Aug-2018

Summary

Official Symbol
SELENOHprovided by HGNC
Official Full Name
selenoprotein Hprovided by HGNC
Primary source
HGNC:HGNC:18251
See related
Ensembl:ENSG00000211450 MIM:607914; Vega:OTTHUMG00000167202
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SELH; C11orf31; C17orf10
Summary
This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]
Expression
Ubiquitous expression in adrenal (RPKM 17.7), spleen (RPKM 16.5) and 25 other tissues See more
Orthologs

Genomic context

See SELENOH in Genome Data Viewer
Location:
11q12.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (57741250..57743554)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57508722..57510883)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene TMX2-CTNND1 readthrough (NMD candidate) Neighboring gene mediator complex subunit 19 Neighboring gene peptidylprolyl isomerase A pseudogene 42 Neighboring gene thioredoxin related transmembrane protein 2 Neighboring gene BTB domain containing 18 Neighboring gene catenin delta 1 Neighboring gene olfactory receptor family 5 subfamily BA member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321335.1NP_001308264.1  selenoprotein H

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate exon in the 3' non-coding region compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF085883, BG714263, BX493234, R38402
    Consensus CDS
    CCDS44602.1
    UniProtKB/Swiss-Prot
    Q8IZQ5
    Conserved Domains (1) summary
    TIGR02174
    Location:36119
    CXXU_selWTH; selT/selW/selH selenoprotein domain
  2. NM_170746.3NP_734467.1  selenoprotein H

    See identical proteins and their annotated locations for NP_734467.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF085883, AF536829, BX493234, R38402
    Consensus CDS
    CCDS44602.1
    UniProtKB/Swiss-Prot
    Q8IZQ5
    Related
    ENSP00000434511.1, OTTHUMP00000235475, ENST00000534355.5, OTTHUMT00000393716
    Conserved Domains (1) summary
    TIGR02174
    Location:36119
    CXXU_selWTH; selT/selW/selH selenoprotein domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    57741250..57743554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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