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Rilp Rab interacting lysosomal protein [ Mus musculus (house mouse) ]

Gene ID: 280408, updated on 5-Mar-2024

Summary

Official Symbol
Rilpprovided by MGI
Official Full Name
Rab interacting lysosomal proteinprovided by MGI
Primary source
MGI:MGI:2144271
See related
Ensembl:ENSMUSG00000038195 AllianceGenome:MGI:2144271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm857
Summary
Predicted to enable dynein light intermediate chain binding activity and small GTPase binding activity. Predicted to be involved in several processes, including early endosome to late endosome transport; intralumenal vesicle formation; and regulation of protein catabolic process. Predicted to act upstream of or within protein transport. Located in mitochondrion. Part of protein-containing complex. Is expressed in brown fat; ileum; liver; male reproductive gland or organ; and metanephros. Orthologous to human RILP (Rab interacting lysosomal protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 16.4), liver adult (RPKM 13.1) and 19 other tissues See more
Orthologs
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Genomic context

See Rilp in Genome Data Viewer
Location:
11 B5; 11 45.92 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75400920..75403994)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75510094..75513168)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene TLC domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E591 Neighboring gene pre-mRNA processing factor 8 Neighboring gene STARR-positive B cell enhancer ABC_E7017 Neighboring gene scavenger receptor class F, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E9036 Neighboring gene STARR-positive B cell enhancer ABC_E10689 Neighboring gene STARR-seq mESC enhancer starr_29997 Neighboring gene solute carrier family 43, member 2 Neighboring gene predicted gene 45606

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dynein light intermediate chain binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in early endosome to late endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in endosome transport via multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intralumenal vesicle formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of multivesicular body size ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rab-interacting lysosomal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029938.2NP_001025109.1  rab-interacting lysosomal protein

    See identical proteins and their annotated locations for NP_001025109.1

    Status: VALIDATED

    Source sequence(s)
    AK139016, AK160517, AW012811, BC038146
    Consensus CDS
    CCDS25049.1
    UniProtKB/Swiss-Prot
    Q5ND29, Q80WB8, Q8CHY9
    UniProtKB/TrEMBL
    Q14AQ2
    Related
    ENSMUSP00000037238.7, ENSMUST00000042972.7
    Conserved Domains (2) summary
    cd14445
    Location:11107
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    pfam11461
    Location:224281
    RILP; Rab interacting lysosomal protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    75400920..75403994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)