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GOLGB1 golgin B1 [ Homo sapiens (human) ]

Gene ID: 2804, updated on 12-Oct-2019

Summary

Official Symbol
GOLGB1provided by HGNC
Official Full Name
golgin B1provided by HGNC
Primary source
HGNC:HGNC:4429
See related
Ensembl:ENSG00000173230 MIM:602500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCP; GCP372; GOLIM1
Expression
Ubiquitous expression in thyroid (RPKM 16.1), prostate (RPKM 15.7) and 25 other tissues See more
Orthologs

Genomic context

See GOLGB1 in Genome Data Viewer
Location:
3q13.33
Exon count:
27
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (121663199..121751169, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (121382046..121468662, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene hematopoietic cell-specific Lyn substrate 1 Neighboring gene RNA, 7SL, cytoplasmic 172, pseudogene Neighboring gene RNA, U4 small nuclear 62, pseudogene Neighboring gene IQ motif containing B1 Neighboring gene ELL associated factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 co-localizes with the Golgi apparatus protein giantin in HIV-transfected 293T cells PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 co-localizes with the Golgi apparatus protein giantin in HIV-transfected 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
    Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
  • COPI-mediated anterograde transport, organism-specific biosystem (from REACTOME)
    COPI-mediated anterograde transport, organism-specific biosystemThe ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2...
  • Clathrin derived vesicle budding, organism-specific biosystem (from REACTOME)
    Clathrin derived vesicle budding, organism-specific biosystemThere at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the cl...
  • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
    ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
  • Golgi Associated Vesicle Biogenesis, organism-specific biosystem (from REACTOME)
    Golgi Associated Vesicle Biogenesis, organism-specific biosystemProteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell ...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
    Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
  • trans-Golgi Network Vesicle Budding, organism-specific biosystem (from REACTOME)
    trans-Golgi Network Vesicle Budding, organism-specific biosystemAfter passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membran...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37232, DKFZp686F09142

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
Golgi organization TAS
Traceable Author Statement
more info
PubMed 
protein localization to pericentriolar material IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
Golgi stack TAS
Traceable Author Statement
more info
PubMed 
cis-Golgi network IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
golgin subfamily B member 1
Names
372 kDa Golgi complex-associated protein
giantin
golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1
golgi integral membrane protein 1
golgin B1, golgi integral membrane protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256486.2NP_001243415.1  golgin subfamily B member 1 isoform 1

    See identical proteins and their annotated locations for NP_001243415.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA127633, AB371588, AB593126, BP320001
    Consensus CDS
    CCDS58847.1
    UniProtKB/Swiss-Prot
    Q14789
    Related
    ENSP00000377275.3, ENST00000393667.7
    Conserved Domains (4) summary
    COG1196
    Location:8141650
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:19042778
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13942326
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11601223
    Ax_dynein_light; Axonemal dynein light chain
  2. NM_001256487.2NP_001243416.1  golgin subfamily B member 1 isoform 3

    See identical proteins and their annotated locations for NP_001243416.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site at its 5' end and initiates translation at a downstream start codon, compared to variant 1. It also uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AA127633, AB593126, BP320001, D25542
    UniProtKB/Swiss-Prot
    Q14789
    Conserved Domains (4) summary
    COG1196
    Location:7751611
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18652739
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13552287
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11211184
    Ax_dynein_light; Axonemal dynein light chain
  3. NM_001256488.1NP_001243417.1  golgin subfamily B member 1 isoform 4

    See identical proteins and their annotated locations for NP_001243417.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site at its 5' end and initiates translation at a downstream start codon, compared to variant 1. It also lacks an internal in-frame exon and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AA127633, AB593126, BP320001, X75304
    Consensus CDS
    CCDS74989.1
    UniProtKB/Swiss-Prot
    Q14789
    Related
    ENSP00000484083.1, ENST00000614479.4
    Conserved Domains (4) summary
    COG1196
    Location:7341570
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18242698
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13142246
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:10801143
    Ax_dynein_light; Axonemal dynein light chain
  4. NM_001366282.2NP_001353211.1  golgin subfamily B member 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC119736, AC133750
    Conserved Domains (1) summary
    cl25732
    Location:13172187
    SMC_N; RecF/RecN/SMC N terminal domain
  5. NM_001366283.2NP_001353212.1  golgin subfamily B member 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC119736, AC133750
    Conserved Domains (1) summary
    cl25732
    Location:12762146
    SMC_N; RecF/RecN/SMC N terminal domain
  6. NM_001366284.2NP_001353213.1  golgin subfamily B member 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC119736, AC133750
    Conserved Domains (1) summary
    cl25732
    Location:12372107
    SMC_N; RecF/RecN/SMC N terminal domain
  7. NM_004487.5NP_004478.3  golgin subfamily B member 1 isoform 2

    See identical proteins and their annotated locations for NP_004478.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the 5' and 3' coding regions, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AA127633, AB593126, X75304
    Consensus CDS
    CCDS3004.1
    UniProtKB/Swiss-Prot
    Q14789
    Related
    ENSP00000341848.5, ENST00000340645.9
    Conserved Domains (4) summary
    COG1196
    Location:8091645
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18992773
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13892321
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11551218
    Ax_dynein_light; Axonemal dynein light chain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    121663199..121751169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512699.3XP_011511001.1  golgin subfamily B member 1 isoform X1

    See identical proteins and their annotated locations for XP_011511001.1

    UniProtKB/Swiss-Prot
    Q14789
    Conserved Domains (4) summary
    COG1196
    Location:8141650
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:19042778
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13942326
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11601223
    Ax_dynein_light; Axonemal dynein light chain
  2. XM_017006193.1XP_016861682.1  golgin subfamily B member 1 isoform X8

  3. XM_017006192.1XP_016861681.1  golgin subfamily B member 1 isoform X7

  4. XM_005247372.4XP_005247429.1  golgin subfamily B member 1 isoform X5

    Conserved Domains (4) summary
    COG1196
    Location:7751611
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18652739
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13552287
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11211184
    Ax_dynein_light; Axonemal dynein light chain
  5. XM_017006190.1XP_016861679.1  golgin subfamily B member 1 isoform X4

    Conserved Domains (4) summary
    COG1196
    Location:8081644
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18982772
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13882320
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11541217
    Ax_dynein_light; Axonemal dynein light chain
  6. XM_006713591.2XP_006713654.1  golgin subfamily B member 1 isoform X11

    Conserved Domains (4) summary
    COG1196
    Location:7341570
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18242698
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13142246
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:10801143
    Ax_dynein_light; Axonemal dynein light chain
  7. XM_005247373.2XP_005247430.1  golgin subfamily B member 1 isoform X6

    Conserved Domains (4) summary
    COG1196
    Location:7731609
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18632737
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13532285
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11191182
    Ax_dynein_light; Axonemal dynein light chain
  8. XM_006713589.2XP_006713652.1  golgin subfamily B member 1 isoform X4

    Conserved Domains (4) summary
    COG1196
    Location:8081644
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18982772
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13882320
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11541217
    Ax_dynein_light; Axonemal dynein light chain
  9. XM_006713588.2XP_006713651.1  golgin subfamily B member 1 isoform X3

    Conserved Domains (4) summary
    COG1196
    Location:8091645
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18992773
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13892321
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11551218
    Ax_dynein_light; Axonemal dynein light chain
  10. XM_017006191.1XP_016861680.1  golgin subfamily B member 1 isoform X6

    Conserved Domains (4) summary
    COG1196
    Location:7731609
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18632737
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13532285
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11191182
    Ax_dynein_light; Axonemal dynein light chain
  11. XM_017006189.1XP_016861678.1  golgin subfamily B member 1 isoform X3

    Conserved Domains (4) summary
    COG1196
    Location:8091645
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18992773
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13892321
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11551218
    Ax_dynein_light; Axonemal dynein light chain
  12. XM_005247371.4XP_005247428.1  golgin subfamily B member 1 isoform X1

    See identical proteins and their annotated locations for XP_005247428.1

    UniProtKB/Swiss-Prot
    Q14789
    Conserved Domains (4) summary
    COG1196
    Location:8141650
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:19042778
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13942326
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11601223
    Ax_dynein_light; Axonemal dynein light chain
  13. XM_017006195.1XP_016861684.1  golgin subfamily B member 1 isoform X12

RNA

  1. XR_001740103.2 RNA Sequence

  2. XR_001740104.2 RNA Sequence

  3. XR_001740106.2 RNA Sequence

  4. XR_001740105.2 RNA Sequence

    Related
    ENST00000482512.5
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