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GOLGA4 golgin A4 [ Homo sapiens (human) ]

Gene ID: 2803, updated on 1-Jun-2020

Summary

Official Symbol
GOLGA4provided by HGNC
Official Full Name
golgin A4provided by HGNC
Primary source
HGNC:HGNC:4427
See related
Ensembl:ENSG00000144674 MIM:602509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCP2; GOLG; p230; CRPF46; MU-RMS-40.18
Summary
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
Expression
Ubiquitous expression in thyroid (RPKM 27.2), testis (RPKM 25.9) and 25 other tissues See more
Orthologs

Genomic context

See GOLGA4 in Genome Data Viewer
Location:
3p22.2
Exon count:
29
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (37243269..37366879)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (37284682..37408370)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377642 Neighboring gene CRISPRi-validated cis-regulatory element chr3.1280 Neighboring gene uncharacterized FLJ31715 Neighboring gene transcription elongation factor A1 pseudogene 2 Neighboring gene RNA, 5S ribosomal pseudogene 129 Neighboring gene chromosome 3 open reading frame 35 Neighboring gene integrin subunit alpha 9 Neighboring gene RNA, U7 small nuclear 73 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120/MBL complex co-localizes with the ER marker Erp57 and the Golgi marker p230 at subcellular perinuclear compartments in neuronal cells PubMed
Nef nef Genome-wide shRNA screening identifies GOLGA4, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed
Vpu vpu HIV-1 Vpu co-localizes with the TGN marker p230 (Golgin) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi to plasma membrane protein transport IDA
Inferred from Direct Assay
more info
PubMed 
Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of axon extension IDA
Inferred from Direct Assay
more info
PubMed 
vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
trans-Golgi network TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
golgin subfamily A member 4
Names
256 kDa golgin
72.1 protein
centrosome-related protein F46
golgi autoantigen, golgin subfamily a, 4
golgin-240
golgin-245
protein 72.1
trans-Golgi p230

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047053.1 RefSeqGene

    Range
    5081..128689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001172713.2NP_001166184.1  golgin subfamily A member 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB209693, AW881112, BC045543, U41740
    Consensus CDS
    CCDS54564.1
    UniProtKB/Swiss-Prot
    Q13439
    UniProtKB/TrEMBL
    Q49A56
    Related
    ENSP00000349305.4, ENST00000356847.8
    Conserved Domains (2) summary
    smart00755
    Location:21872230
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:14682109
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  2. NM_002078.5NP_002069.2  golgin subfamily A member 4 isoform 2

    See identical proteins and their annotated locations for NP_002069.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' region and has two additional exons in the 3' region; one is in frame and another one includes a stop codon, as compared to variant 1. The resulting isoform (2) is shorter; it lacks a segment in the N-terminal region and has an additional segment in the C-terminal region as well as has a different and longer C-terminus, as compared to isoform 1.
    Source sequence(s)
    AW881112, BC045543, U41740
    Consensus CDS
    CCDS2666.1
    UniProtKB/Swiss-Prot
    Q13439
    UniProtKB/TrEMBL
    Q49A56
    Related
    ENSP00000354486.2, ENST00000361924.6
    Conserved Domains (2) summary
    smart00755
    Location:21722215
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:14462141
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    37243269..37366879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265075.1XP_005265132.1  golgin subfamily A member 4 isoform X11

    Conserved Domains (2) summary
    smart00755
    Location:21562199
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:14302125
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  2. XM_017006188.1XP_016861677.1  golgin subfamily A member 4 isoform X12

  3. XM_005265069.3XP_005265126.1  golgin subfamily A member 4 isoform X1

    Conserved Domains (2) summary
    smart00755
    Location:22272270
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:15012196
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  4. XM_005265070.3XP_005265127.1  golgin subfamily A member 4 isoform X2

    Conserved Domains (2) summary
    smart00755
    Location:22272270
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:15012196
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  5. XM_005265071.3XP_005265128.1  golgin subfamily A member 4 isoform X3

    Conserved Domains (2) summary
    smart00755
    Location:22202263
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:15012142
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  6. XM_017006184.1XP_016861673.1  golgin subfamily A member 4 isoform X4

  7. XM_005265072.3XP_005265129.1  golgin subfamily A member 4 isoform X5

    Conserved Domains (2) summary
    smart00755
    Location:22112254
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:14852180
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  8. XM_006713110.2XP_006713173.1  golgin subfamily A member 4 isoform X8

    Conserved Domains (2) summary
    smart00755
    Location:21922235
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:14662161
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  9. XM_024453458.1XP_024309226.1  golgin subfamily A member 4 isoform X14

    Conserved Domains (3) summary
    smart00755
    Location:20372080
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    cl25732
    Location:13112006
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:180862
    Neuromodulin_N; Gap junction protein N-terminal region
  10. XM_005265073.1XP_005265130.1  golgin subfamily A member 4 isoform X6

    Conserved Domains (2) summary
    smart00755
    Location:21942237
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:14682163
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  11. XM_005265074.1XP_005265131.1  golgin subfamily A member 4 isoform X9

    Conserved Domains (2) summary
    smart00755
    Location:21872230
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:14682109
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  12. XM_017006187.1XP_016861676.1  golgin subfamily A member 4 isoform X10

  13. XM_024453457.1XP_024309225.1  golgin subfamily A member 4 isoform X13

    Conserved Domains (3) summary
    smart00755
    Location:20532096
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    cl25732
    Location:13272022
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:196878
    Neuromodulin_N; Gap junction protein N-terminal region
  14. XM_024453456.1XP_024309224.1  golgin subfamily A member 4 isoform X13

    Related
    ENSP00000405842.1, ENST00000437131.1
    Conserved Domains (3) summary
    smart00755
    Location:20532096
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    cl25732
    Location:13272022
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:196878
    Neuromodulin_N; Gap junction protein N-terminal region
  15. XM_011533598.3XP_011531900.1  golgin subfamily A member 4 isoform X15

    Conserved Domains (2) summary
    smart00755
    Location:17351778
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:10091704
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  16. XM_017006186.1XP_016861675.1  golgin subfamily A member 4 isoform X7

  17. XM_017006185.1XP_016861674.1  golgin subfamily A member 4 isoform X7

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