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GOLGA4 golgin A4 [ Homo sapiens (human) ]

Gene ID: 2803, updated on 17-Jun-2024

Summary

Official Symbol
GOLGA4provided by HGNC
Official Full Name
golgin A4provided by HGNC
Primary source
HGNC:HGNC:4427
See related
Ensembl:ENSG00000144674 MIM:602509; AllianceGenome:HGNC:4427
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCP2; GOLG; p230; CRPF46; MU-RMS-40.18
Summary
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
Expression
Ubiquitous expression in thyroid (RPKM 27.2), testis (RPKM 25.9) and 25 other tissues See more
Orthologs
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Genomic context

See GOLGA4 in Genome Data Viewer
Location:
3p22.2
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (37243271..37366879)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (37244671..37368411)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (37284762..37408370)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377642 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124909483 Neighboring gene CRISPRi-validated cis-regulatory element chr3.1280 Neighboring gene H3K27ac hESC enhancers GRCh37_chr3:37283961-37284580 and GRCh37_chr3:37284581-37285200 Neighboring gene GOLGA4 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:37339657-37340856 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:37343371-37344032 Neighboring gene transcription elongation factor A1 pseudogene 2 Neighboring gene MPRA-validated peak4611 silencer Neighboring gene RNA, 5S ribosomal pseudogene 129 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:37485219-37485403 Neighboring gene APRG1 tumor suppressor candidate Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14199 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37516063-37516575 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37516576-37517087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37539704-37540204 Neighboring gene integrin subunit alpha 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37579429-37579930 Neighboring gene RNA, U7 small nuclear 73 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120/MBL complex co-localizes with the ER marker Erp57 and the Golgi marker p230 at subcellular perinuclear compartments in neuronal cells PubMed
Nef nef Genome-wide shRNA screening identifies GOLGA4, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed
Vpu vpu HIV-1 Vpu co-localizes with the TGN marker p230 (Golgin) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in trans-Golgi network TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
golgin subfamily A member 4
Names
256 kDa golgin
72.1 protein
centrosome-related protein F46
golgi autoantigen, golgin subfamily a, 4
golgin-240
golgin-245
protein 72.1
trans-Golgi p230

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047053.1 RefSeqGene

    Range
    5081..128689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001172713.3NP_001166184.1  golgin subfamily A member 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC097359
    Consensus CDS
    CCDS54564.1
    UniProtKB/Swiss-Prot
    Q13439
    UniProtKB/TrEMBL
    Q49A56
    Related
    ENSP00000349305.4, ENST00000356847.8
    Conserved Domains (2) summary
    smart00755
    Location:21872230
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:14682109
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  2. NM_001410721.2NP_001397650.1  golgin subfamily A member 4 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC097359
    Consensus CDS
    CCDS93242.1
    UniProtKB/TrEMBL
    H0Y6I0
    Related
    ENSP00000405842.2, ENST00000437131.2
  3. NM_001429190.1NP_001416119.1  golgin subfamily A member 4 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC097359
  4. NM_001429191.1NP_001416120.1  golgin subfamily A member 4 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC097359
    UniProtKB/TrEMBL
    A0A8V8TQI6
  5. NM_001429193.1NP_001416122.1  golgin subfamily A member 4 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC097359
  6. NM_001429196.1NP_001416125.1  golgin subfamily A member 4 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC097359
  7. NM_001429198.1NP_001416127.1  golgin subfamily A member 4 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC097359
  8. NM_001429201.1NP_001416130.1  golgin subfamily A member 4 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC097359
  9. NM_001429202.1NP_001416131.1  golgin subfamily A member 4 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC097359
  10. NM_002078.5NP_002069.2  golgin subfamily A member 4 isoform 2

    See identical proteins and their annotated locations for NP_002069.2

    Status: REVIEWED

    Source sequence(s)
    AW881112, BC045543, U41740
    Consensus CDS
    CCDS2666.1
    UniProtKB/Swiss-Prot
    F8W8Q7, Q13270, Q13439, Q13654, Q14436, Q59EW8
    Related
    ENSP00000354486.2, ENST00000361924.7
    Conserved Domains (4) summary
    PTZ00121
    Location:315997
    PTZ00121; MAEBL; Provisional
    smart00755
    Location:21722215
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:14462141
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:136452
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    37243271..37366879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447981.1XP_047303937.1  golgin subfamily A member 4 isoform X7

  2. XM_047447980.1XP_047303936.1  golgin subfamily A member 4 isoform X7

  3. XM_024453457.2XP_024309225.1  golgin subfamily A member 4 isoform X17

    Conserved Domains (3) summary
    smart00755
    Location:20532096
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    cl25732
    Location:13272022
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:196878
    Neuromodulin_N; Gap junction protein N-terminal region
  4. XM_005265069.4XP_005265126.1  golgin subfamily A member 4 isoform X1

    UniProtKB/TrEMBL
    C9J0Y3
    Related
    ENSP00000392907.2, ENST00000431105.2
    Conserved Domains (2) summary
    smart00755
    Location:22272270
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:15012196
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  5. XM_005265070.4XP_005265127.1  golgin subfamily A member 4 isoform X2

    UniProtKB/TrEMBL
    A0A9L9PX25
    Related
    ENSP00000516454.1, ENST00000706569.1
    Conserved Domains (2) summary
    smart00755
    Location:22272270
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:15012196
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  6. XM_005265071.4XP_005265128.1  golgin subfamily A member 4 isoform X3

    Conserved Domains (2) summary
    smart00755
    Location:22202263
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:15012142
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  7. XM_017006184.2XP_016861673.1  golgin subfamily A member 4 isoform X4

  8. XM_005265072.4XP_005265129.1  golgin subfamily A member 4 isoform X5

    Conserved Domains (2) summary
    smart00755
    Location:22112254
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:14852180
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  9. XM_006713110.3XP_006713173.1  golgin subfamily A member 4 isoform X8

    Conserved Domains (2) summary
    smart00755
    Location:21922235
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:14662161
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  10. XM_005265073.2XP_005265130.1  golgin subfamily A member 4 isoform X6

    Related
    ENSP00000514745.1, ENST00000699995.1
    Conserved Domains (2) summary
    smart00755
    Location:21942237
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:14682163
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  11. XM_005265074.2XP_005265131.1  golgin subfamily A member 4 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPI8
    Related
    ENSP00000514746.1, ENST00000699996.1
    Conserved Domains (2) summary
    smart00755
    Location:21872230
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:14682109
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  12. XM_017006187.2XP_016861676.1  golgin subfamily A member 4 isoform X10

  13. XM_047447983.1XP_047303939.1  golgin subfamily A member 4 isoform X11

  14. XM_047447985.1XP_047303941.1  golgin subfamily A member 4 isoform X13

  15. XM_047447986.1XP_047303942.1  golgin subfamily A member 4 isoform X14

  16. XM_047447984.1XP_047303940.1  golgin subfamily A member 4 isoform X12

  17. XM_005265075.2XP_005265132.1  golgin subfamily A member 4 isoform X15

    Conserved Domains (2) summary
    smart00755
    Location:21562199
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:14302125
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  18. XM_017006188.2XP_016861677.1  golgin subfamily A member 4 isoform X16

  19. XM_011533598.4XP_011531900.1  golgin subfamily A member 4 isoform X18

    Conserved Domains (2) summary
    smart00755
    Location:17351778
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:10091704
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    37244671..37368411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346209.1XP_054202184.1  golgin subfamily A member 4 isoform X7

  2. XM_054346208.1XP_054202183.1  golgin subfamily A member 4 isoform X7

  3. XM_054346219.1XP_054202194.1  golgin subfamily A member 4 isoform X17

  4. XM_054346202.1XP_054202177.1  golgin subfamily A member 4 isoform X1

    UniProtKB/TrEMBL
    C9J0Y3
  5. XM_054346203.1XP_054202178.1  golgin subfamily A member 4 isoform X2

    UniProtKB/TrEMBL
    A0A9L9PX25
  6. XM_054346204.1XP_054202179.1  golgin subfamily A member 4 isoform X3

  7. XM_054346205.1XP_054202180.1  golgin subfamily A member 4 isoform X4

  8. XM_054346206.1XP_054202181.1  golgin subfamily A member 4 isoform X5

  9. XM_054346210.1XP_054202185.1  golgin subfamily A member 4 isoform X8

  10. XM_054346207.1XP_054202182.1  golgin subfamily A member 4 isoform X6

  11. XM_054346211.1XP_054202186.1  golgin subfamily A member 4 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPI8
  12. XM_054346212.1XP_054202187.1  golgin subfamily A member 4 isoform X10

  13. XM_054346213.1XP_054202188.1  golgin subfamily A member 4 isoform X11

  14. XM_054346215.1XP_054202190.1  golgin subfamily A member 4 isoform X13

  15. XM_054346216.1XP_054202191.1  golgin subfamily A member 4 isoform X14

  16. XM_054346214.1XP_054202189.1  golgin subfamily A member 4 isoform X12

  17. XM_054346217.1XP_054202192.1  golgin subfamily A member 4 isoform X15

  18. XM_054346218.1XP_054202193.1  golgin subfamily A member 4 isoform X16

  19. XM_054346220.1XP_054202195.1  golgin subfamily A member 4 isoform X18