Format

Send to:

Choose Destination

GOLGA3 golgin A3 [ Homo sapiens (human) ]

Gene ID: 2802, updated on 17-Jun-2019

Summary

Official Symbol
GOLGA3provided by HGNC
Official Full Name
golgin A3provided by HGNC
Primary source
HGNC:HGNC:4426
See related
Ensembl:ENSG00000090615 MIM:602581
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEA-2; GCP170
Summary
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Feb 2010]
Expression
Ubiquitous expression in colon (RPKM 8.3), brain (RPKM 6.7) and 25 other tissues See more
Orthologs

Genomic context

See GOLGA3 in Genome Data Viewer
Location:
12q24.33
Exon count:
30
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (132768913..132829131, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133345495..133405659, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 379 Neighboring gene ankyrin repeat and LEM domain containing 2 Neighboring gene TPD52 like 2 pseudogene Neighboring gene ribosomal protein S11 pseudogene 5 Neighboring gene RNA, U6 small nuclear 327, pseudogene Neighboring gene checkpoint with forkhead and ring finger domains

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
intra-Golgi vesicle-mediated transport NAS
Non-traceable Author Statement
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
PubMed 
Golgi transport complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi transport complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
golgin subfamily A member 3
Names
Golgi membrane associated protein
Golgi peripheral membrane protein
SY2/SY10 protein
golgi autoantigen, golgin subfamily a, 3
golgi complex-associated protein of 170 kDa
golgin-160
golgin-165
male enhanced antigen-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029887.1 RefSeqGene

    Range
    5139..64932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001172557.2NP_001166028.1  golgin subfamily A member 3 isoform 2

    See identical proteins and their annotated locations for NP_001166028.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR and contains a different 3' end, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC127070, BC146675, D63997
    Consensus CDS
    CCDS53846.1
    UniProtKB/Swiss-Prot
    Q08378
    Related
    ENSP00000442603.1, ENST00000545875.4
    Conserved Domains (2) summary
    pfam05010
    Location:812997
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl19219
    Location:812886
    DUF342; Protein of unknown function (DUF342)
  2. NM_005895.4NP_005886.2  golgin subfamily A member 3 isoform 1

    See identical proteins and their annotated locations for NP_005886.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC127070, AC136467, AF485338, BC060826, BF902971, D63997
    Consensus CDS
    CCDS9281.1
    UniProtKB/Swiss-Prot
    Q08378
    Related
    ENSP00000204726.3, ENST00000204726.8
    Conserved Domains (1) summary
    cl25732
    Location:6301358
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    132768913..132829131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448943.1XP_024304711.1  golgin subfamily A member 3 isoform X2

    Conserved Domains (1) summary
    cl25732
    Location:5901318
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_006719737.3XP_006719800.1  golgin subfamily A member 3 isoform X1

    See identical proteins and their annotated locations for XP_006719800.1

    UniProtKB/Swiss-Prot
    Q08378
    Conserved Domains (1) summary
    cl25732
    Location:6301358
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_011534793.2XP_011533095.1  golgin subfamily A member 3 isoform X3

    Conserved Domains (3) summary
    PRK03918
    Location:7781268
    PRK03918; chromosome segregation protein; Provisional
    pfam05010
    Location:721906
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl19219
    Location:721795
    DUF342; Protein of unknown function (DUF342)
  4. XM_005266164.4XP_005266221.1  golgin subfamily A member 3 isoform X2

    See identical proteins and their annotated locations for XP_005266221.1

    Conserved Domains (1) summary
    cl25732
    Location:5901318
    SMC_N; RecF/RecN/SMC N terminal domain
  5. XM_006719736.3XP_006719799.1  golgin subfamily A member 3 isoform X1

    See identical proteins and their annotated locations for XP_006719799.1

    UniProtKB/Swiss-Prot
    Q08378
    Related
    ENSP00000410378.2, ENST00000450791.7
    Conserved Domains (1) summary
    cl25732
    Location:6301358
    SMC_N; RecF/RecN/SMC N terminal domain
  6. XM_024448941.1XP_024304709.1  golgin subfamily A member 3 isoform X1

    Conserved Domains (1) summary
    cl25732
    Location:6301358
    SMC_N; RecF/RecN/SMC N terminal domain
  7. XM_024448940.1XP_024304708.1  golgin subfamily A member 3 isoform X1

    Conserved Domains (1) summary
    cl25732
    Location:6301358
    SMC_N; RecF/RecN/SMC N terminal domain
  8. XM_024448939.1XP_024304707.1  golgin subfamily A member 3 isoform X1

    Conserved Domains (1) summary
    cl25732
    Location:6301358
    SMC_N; RecF/RecN/SMC N terminal domain
  9. XM_024448942.1XP_024304710.1  golgin subfamily A member 3 isoform X1

    Conserved Domains (1) summary
    cl25732
    Location:6301358
    SMC_N; RecF/RecN/SMC N terminal domain
  10. XM_005266167.4XP_005266224.1  golgin subfamily A member 3 isoform X4

    Conserved Domains (2) summary
    COG1196
    Location:4391167
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19219
    Location:621695
    DUF342; Protein of unknown function (DUF342)
  11. XM_011534794.2XP_011533096.1  golgin subfamily A member 3 isoform X5

    Conserved Domains (3) summary
    TIGR02168
    Location:20694
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01496
    Location:446526
    V_ATPase_I; V-type ATPase 116kDa subunit family
    cl19219
    Location:164238
    DUF342; Protein of unknown function (DUF342)
Support Center