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GOLGA2 golgin A2 [ Homo sapiens (human) ]

Gene ID: 2801, updated on 5-Sep-2021

Summary

Official Symbol
GOLGA2provided by HGNC
Official Full Name
golgin A2provided by HGNC
Primary source
HGNC:HGNC:4425
See related
Ensembl:ENSG00000167110 MIM:602580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GM130
Summary
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Feb 2010]
Expression
Ubiquitous expression in prostate (RPKM 18.6), esophagus (RPKM 17.4) and 25 other tissues See more
Orthologs
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Genomic context

See GOLGA2 in Genome Data Viewer
Location:
9q34.11
Exon count:
27
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (128255829..128276007, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131018108..131038231, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene dynamin 1 Neighboring gene microRNA 199b Neighboring gene microRNA 3154 Neighboring gene SWI5 homologous recombination repair protein Neighboring gene Sharpr-MPRA regulatory region 14380 Neighboring gene uncharacterized LOC105376286 Neighboring gene TruB pseudouridine synthase family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies GOLGA2, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed
nef HIV-1 Nef causes the FMS N-glycosylation defect and induces relocalization of the GM130 by activating the p56Hck/MEK/ERK/GRASP65 phosphorylation cascade in the Golgi PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20672

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables importin-alpha family protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Golgi ribbon formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in asymmetric cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in centrosome cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in meiotic spindle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in microtubule nucleation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein homotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in COPII-coated ER to Golgi transport vesicle IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Golgi cis cisterna IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi cis cisterna IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Golgi cisterna membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi cisterna membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane TAS
Traceable Author Statement
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
golgin subfamily A member 2
Names
130 kDa cis-Golgi matrix protein
GM130 autoantigen
Golgi matrix protein GM130
SY11 protein
golgi autoantigen, golgin subfamily a, 2
golgin-95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366244.2NP_001353173.2  golgin subfamily A member 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL590708
    Conserved Domains (3) summary
    COG1196
    Location:183473
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15070
    Location:408935
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:9801025
    GM130_C; GM130 C-terminal binding motif
  2. NM_001366246.2NP_001353175.2  golgin subfamily A member 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL590708
    Conserved Domains (3) summary
    TIGR02168
    Location:178445
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15070
    Location:381908
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:953998
    GM130_C; GM130 C-terminal binding motif
  3. NM_001389695.2NP_001376624.2  golgin subfamily A member 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL590708
    Conserved Domains (3) summary
    COG1196
    Location:187468
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15070
    Location:403930
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:9751020
    GM130_C; GM130 C-terminal binding motif
  4. NM_001389696.2NP_001376625.2  golgin subfamily A member 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL590708
    Conserved Domains (3) summary
    COG1196
    Location:183500
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15070
    Location:408929
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:9741019
    GM130_C; GM130 C-terminal binding motif
  5. NM_001389697.2NP_001376626.2  golgin subfamily A member 2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL590708
    Conserved Domains (3) summary
    TIGR02168
    Location:152441
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15070
    Location:377904
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:949994
    GM130_C; GM130 C-terminal binding motif
  6. NM_001389698.2NP_001376627.2  golgin subfamily A member 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL590708
    Conserved Domains (3) summary
    COG0419
    Location:187554
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam15070
    Location:381902
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:947992
    GM130_C; GM130 C-terminal binding motif
  7. NM_001389699.2NP_001376628.2  golgin subfamily A member 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL590708
    Conserved Domains (3) summary
    COG1196
    Location:186433
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15070
    Location:368895
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:940985
    GM130_C; GM130 C-terminal binding motif
  8. NM_001389700.2NP_001376629.2  golgin subfamily A member 2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL590708
    Conserved Domains (3) summary
    TIGR02168
    Location:154432
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15070
    Location:368895
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:940985
    GM130_C; GM130 C-terminal binding motif
  9. NM_001389701.2NP_001376630.2  golgin subfamily A member 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL590708
    Conserved Domains (3) summary
    TIGR02168
    Location:151418
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15070
    Location:354881
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:926971
    GM130_C; GM130 C-terminal binding motif
  10. NM_001389702.2NP_001376631.2  golgin subfamily A member 2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL590708
    Conserved Domains (3) summary
    COG1196
    Location:121411
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15070
    Location:346873
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:918963
    GM130_C; GM130 C-terminal binding motif
  11. NM_001389703.2NP_001376632.2  golgin subfamily A member 2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL590708
    Conserved Domains (3) summary
    COG1196
    Location:159406
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15070
    Location:341868
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:913958
    GM130_C; GM130 C-terminal binding motif
  12. NM_001389704.2NP_001376633.2  golgin subfamily A member 2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL590708
    Conserved Domains (3) summary
    COG1196
    Location:70355
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15070
    Location:263784
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:829874
    GM130_C; GM130 C-terminal binding motif
  13. NM_001389705.2NP_001376634.2  golgin subfamily A member 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL590708
    Conserved Domains (3) summary
    COG1196
    Location:92348
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15070
    Location:250777
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:822867
    GM130_C; GM130 C-terminal binding motif
  14. NM_004486.6NP_004477.5  golgin subfamily A member 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL590708
    Consensus CDS
    CCDS6896.2
    Related
    ENSP00000478799.1, ENST00000611957.4
    Conserved Domains (3) summary
    COG1196
    Location:156446
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15070
    Location:381908
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:953998
    GM130_C; GM130 C-terminal binding motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    128255829..128276007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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