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GOLGA2 golgin A2 [ Homo sapiens (human) ]

Gene ID: 2801, updated on 27-Jun-2020

Summary

Official Symbol
GOLGA2provided by HGNC
Official Full Name
golgin A2provided by HGNC
Primary source
HGNC:HGNC:4425
See related
Ensembl:ENSG00000167110 MIM:602580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GM130
Summary
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Feb 2010]
Expression
Ubiquitous expression in prostate (RPKM 18.6), esophagus (RPKM 17.4) and 25 other tissues See more
Orthologs

Genomic context

See GOLGA2 in Genome Data Viewer
Location:
9q34.11
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (128255829..128276000, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131018108..131038286, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene dynamin 1 Neighboring gene microRNA 199b Neighboring gene microRNA 3154 Neighboring gene SWI5 homologous recombination repair protein Neighboring gene Sharpr-MPRA regulatory region 14380 Neighboring gene uncharacterized LOC105376286 Neighboring gene TruB pseudouridine synthase family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies GOLGA2, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed
nef HIV-1 Nef causes the FMS N-glycosylation defect and induces relocalization of the GM130 by activating the p56Hck/MEK/ERK/GRASP65 phosphorylation cascade in the Golgi PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20672

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding HDA PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
importin-alpha family protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
syntaxin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
COPII vesicle coating TAS
Traceable Author Statement
more info
 
ER to Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
Golgi disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi ribbon formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
asymmetric cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
centrosome cycle IDA
Inferred from Direct Assay
more info
PubMed 
centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule nucleation IDA
Inferred from Direct Assay
more info
PubMed 
microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 
protein glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
spindle assembly involved in meiosis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
COPII-coated ER to Golgi transport vesicle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi cis cisterna IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi cis cisterna IDA
Inferred from Direct Assay
more info
PubMed 
Golgi cisterna membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi cisterna membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cis-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment membrane TAS
Traceable Author Statement
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
golgin subfamily A member 2
Names
130 kDa cis-Golgi matrix protein
GM130 autoantigen
Golgi matrix protein GM130
SY11 protein
golgi autoantigen, golgin subfamily a, 2
golgin-95

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366244.1NP_001353173.1  golgin subfamily A member 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL590708
    Conserved Domains (2) summary
    pfam15070
    Location:3961017
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    cl25732
    Location:171461
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001366246.1NP_001353175.1  golgin subfamily A member 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL590708
    Conserved Domains (2) summary
    pfam15070
    Location:369990
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    cl25732
    Location:140433
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_004486.5NP_004477.4  golgin subfamily A member 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    BC069268
    Consensus CDS
    CCDS6896.2
    Related
    ENSP00000416097.2, ENST00000421699.6
    Conserved Domains (2) summary
    pfam15070
    Location:369990
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    cl25732
    Location:144434
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    128255829..128276000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251932.1XP_005251989.1  golgin subfamily A member 2 isoform X3

    Conserved Domains (1) summary
    pfam15070
    Location:354975
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
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