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GOLGA1 golgin A1 [ Homo sapiens (human) ]

Gene ID: 2800, updated on 4-Jul-2021

Summary

Official Symbol
GOLGA1provided by HGNC
Official Full Name
golgin A1provided by HGNC
Primary source
HGNC:HGNC:4424
See related
Ensembl:ENSG00000136935 MIM:602502
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
golgin-97
Summary
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein is associated with Sjogren's syndrome. [provided by RefSeq, Feb 2010]
Expression
Ubiquitous expression in testis (RPKM 12.9), skin (RPKM 6.1) and 25 other tissues See more
Orthologs
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Genomic context

See GOLGA1 in Genome Data Viewer
Location:
9q33.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (124878275..124941407, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127640554..127703362, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene WD repeat domain 38 Neighboring gene actin related protein 2/3 complex subunit 5 like Neighboring gene ribosomal protein L35 Neighboring gene RNA, U4 small nuclear 82, pseudogene Neighboring gene suppressor of cancer cell invasion Neighboring gene frataxin pseudogene 2 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 pseudogene 2 Neighboring gene protein phosphatase 6 catalytic subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with golgin A1 (GOLGA1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33154

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
golgin subfamily A member 1
Names
gap junction protein, alpha 4, 37kD
golgi autoantigen, golgin subfamily a, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002077.4NP_002068.2  golgin subfamily A member 1

    Status: REVIEWED

    Source sequence(s)
    AL354928, AL451125
    Consensus CDS
    CCDS6860.1
    Related
    ENSP00000362656.4, ENST00000373555.9
    Conserved Domains (3) summary
    smart00755
    Location:692737
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:249649
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:121447
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    124878275..124941407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717063.4XP_006717126.1  golgin subfamily A member 1 isoform X1

    See identical proteins and their annotated locations for XP_006717126.1

    UniProtKB/Swiss-Prot
    Q92805
    Conserved Domains (3) summary
    smart00755
    Location:692737
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:249649
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:121447
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  2. XM_005251929.4XP_005251986.1  golgin subfamily A member 1 isoform X1

    See identical proteins and their annotated locations for XP_005251986.1

    UniProtKB/Swiss-Prot
    Q92805
    Conserved Domains (3) summary
    smart00755
    Location:692737
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:249649
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:121447
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  3. XM_006717062.4XP_006717125.1  golgin subfamily A member 1 isoform X1

    See identical proteins and their annotated locations for XP_006717125.1

    UniProtKB/Swiss-Prot
    Q92805
    Conserved Domains (3) summary
    smart00755
    Location:692737
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:249649
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:121447
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_929766.1 RNA Sequence

    Related
    ENST00000475407.5
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