Format

Send to:

Choose Destination

Exosc5 exosome component 5 [ Mus musculus (house mouse) ]

Gene ID: 27998, updated on 5-Aug-2018

Summary

Official Symbol
Exosc5provided by MGI
Official Full Name
exosome component 5provided by MGI
Primary source
MGI:MGI:107889
See related
Ensembl:ENSMUSG00000061286 Vega:OTTMUSG00000058396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D7Wsu180e
Expression
Broad expression in testis adult (RPKM 168.2), adrenal adult (RPKM 45.2) and 23 other tissues See more
Orthologs

Genomic context

See Exosc5 in Genome Data Viewer
Location:
7 A3; 7 13.96 cM
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (25659153..25668032)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (26444172..26453051)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 Neighboring gene branched chain ketoacid dehydrogenase E1, alpha polypeptide Neighboring gene transmembrane protein 91 Neighboring gene B9 protein domain 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
DNA deamination ISO
Inferred from Sequence Orthology
more info
 
RNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
U4 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to virus ISO
Inferred from Sequence Orthology
more info
 
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay ISO
Inferred from Sequence Orthology
more info
 
nuclear mRNA surveillance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
polyadenylation-dependent snoRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
 
nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcriptionally active chromatin ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
exosome complex component RRP46
Names
exosome complex exonuclease RRP46
ribosomal RNA-processing protein 46

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138586.3NP_613052.1  exosome complex component RRP46

    See identical proteins and their annotated locations for NP_613052.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AK006475, BB856072, BE854983, BY198385
    Consensus CDS
    CCDS20990.1
    UniProtKB/Swiss-Prot
    Q9CRA8
    Related
    ENSMUSP00000078580.6, OTTMUSP00000074773, ENSMUST00000079634.7, OTTMUST00000143426
    Conserved Domains (2) summary
    TIGR02065
    Location:11232
    ECX1; archaeal exosome-like complex exonuclease 1
    cd11372
    Location:28225
    RNase_PH_RRP46; RRP46 subunit of eukaryotic exosome

RNA

  1. NR_104358.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of an exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC162614, AK007372, BB856072, BE854983, BY196593

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    25659153..25668032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center