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AMY2A amylase alpha 2A [ Homo sapiens (human) ]

Gene ID: 279, updated on 6-Jun-2024

Summary

Official Symbol
AMY2Aprovided by HGNC
Official Full Name
amylase alpha 2Aprovided by HGNC
Primary source
HGNC:HGNC:477
See related
Ensembl:ENSG00000243480 MIM:104650; AllianceGenome:HGNC:477
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PA; AMY2
Summary
This gene encodes a member of the alpha-amylase family of proteins. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, catalyzing the first step in digestion of dietary starch and glycogen. This gene and several family members are present in a gene cluster on chromosome 1. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jan 2015]
Expression
Restricted expression toward pancreas (RPKM 19140.7) See more
Orthologs
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Genomic context

See AMY2A in Genome Data Viewer
Location:
1p21.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (103616651..103625780)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (103466373..103474647)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (104160049..104168402)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1413 Neighboring gene RNA binding region (RNP1, RRM) containing 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:104100112-104100330 Neighboring gene amylase alpha 2B Neighboring gene actin gamma 1 pseudogene 4 Neighboring gene uncharacterized LOC124904594 Neighboring gene amylase alpha 1A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
pancreatic alpha-amylase
Names
1,4-alpha-D-glucan glucanohydrolase
amylase alpha 2A (pancreatic)
glycogenase
pancreatic amylase alpha 2A
NP_000690.1
XP_047274041.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000699.4NP_000690.1  pancreatic alpha-amylase precursor

    See identical proteins and their annotated locations for NP_000690.1

    Status: REVIEWED

    Source sequence(s)
    AC105272
    Consensus CDS
    CCDS783.1
    UniProtKB/Swiss-Prot
    B9EJG1, P04746
    UniProtKB/TrEMBL
    Q53F26
    Related
    ENSP00000397582.2, ENST00000414303.7
    Conserved Domains (2) summary
    cd11317
    Location:25416
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:422510
    Aamy_C; Aamy_C domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    103616651..103625780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418085.1XP_047274041.1  pancreatic alpha-amylase isoform X1

    UniProtKB/Swiss-Prot
    B9EJG1, P04746
    UniProtKB/TrEMBL
    Q53F26

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    103466373..103474647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)