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GNG7 G protein subunit gamma 7 [ Homo sapiens (human) ]

Gene ID: 2788, updated on 5-Aug-2022

Summary

Official Symbol
GNG7provided by HGNC
Official Full Name
G protein subunit gamma 7provided by HGNC
Primary source
HGNC:HGNC:4410
See related
Ensembl:ENSG00000176533 MIM:604430; AllianceGenome:HGNC:4410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HG3B
Summary
Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and regulation of adenylate cyclase activity. Predicted to act upstream of or within behavioral fear response; locomotory behavior; and receptor guanylyl cyclase signaling pathway. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 18.8), heart (RPKM 10.5) and 22 other tissues See more
Orthologs
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Genomic context

See GNG7 in Genome Data Viewer
Location:
19p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (2511219..2702694, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (2487421..2678899, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2511217..2702692, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904614 Neighboring gene Sharpr-MPRA regulatory region 4128 Neighboring gene uncharacterized LOC124904789 Neighboring gene RNA, U6 small nuclear 993, pseudogene Neighboring gene elongin C pseudogene 28 Neighboring gene HNF4 motif-containing MPRA enhancer 50 Neighboring gene Sharpr-MPRA regulatory region 4130 Neighboring gene RNA, 7SL, cytoplasmic 121, pseudogene Neighboring gene Sharpr-MPRA regulatory region 3019 Neighboring gene microRNA 7850 Neighboring gene GNG7 intron CAGE-defined B cell enhancer Neighboring gene DIRAS family GTPase 1 Neighboring gene solute carrier family 39 member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00058

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Names
guanine nucleotide binding protein (G protein), gamma 7
heterotrimeric guanine nucleotide-binding protein 3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052847.3NP_443079.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

    See identical proteins and their annotated locations for NP_443079.1

    Status: VALIDATED

    Source sequence(s)
    AC005512, BC014466, BC053630, DA247608
    Consensus CDS
    CCDS12091.1
    UniProtKB/Swiss-Prot
    B2R496, O60262
    Related
    ENSP00000371594.2, ENST00000382159.8
    Conserved Domains (1) summary
    smart00224
    Location:768
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    2511219..2702694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438629.1XP_047294585.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

    UniProtKB/Swiss-Prot
    B2R496

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    2487421..2678899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)