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Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 278507, updated on 9-Mar-2023

Summary

Official Symbol
Wfikkn2provided by MGI
Official Full Name
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2provided by MGI
Primary source
MGI:MGI:2669209
See related
Ensembl:ENSMUSG00000044177 AllianceGenome:MGI:2669209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gasp1; WFIKKNRP; 2610304F08Rik
Summary
Predicted to enable receptor antagonist activity and transforming growth factor beta binding activity. Acts upstream of or within several processes, including negative regulation of DNA binding activity; roof of mouth development; and transforming growth factor beta receptor signaling pathway. Located in extracellular space. Is expressed in several structures, including central nervous system; genitourinary system; limb; liver; and lung. Orthologous to human WFIKKN2 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 7.3), limb E14.5 (RPKM 4.3) and 14 other tissues See more
Orthologs
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Genomic context

See Wfikkn2 in Genome Data Viewer
Location:
11; 11 D
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94126777..94138613, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (94235951..94247793, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35338 Neighboring gene VISTA enhancer mm1496 Neighboring gene transducer of ErbB-2.1 Neighboring gene predicted gene, 38956 Neighboring gene ANKRD40 C-terminal like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC130508

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables receptor antagonist activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables transforming growth factor beta binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
Names
GASP-1
growth and differentiation factor-associated serum protein 1
mGASP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181819.2NP_861540.2  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_861540.2

    Status: VALIDATED

    Source sequence(s)
    AL645846
    Consensus CDS
    CCDS25251.1
    UniProtKB/Swiss-Prot
    Q5SUS5, Q7TQN3
    Related
    ENSMUSP00000053238.4, ENSMUST00000061469.4
    Conserved Domains (6) summary
    cd05765
    Location:219299
    Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
    cd00104
    Location:133169
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00109
    Location:323374
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cd03575
    Location:450558
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam00014
    Location:380431
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:3786
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    94126777..94138613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249063.4XP_011247365.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011247365.1

    UniProtKB/Swiss-Prot
    Q5SUS5, Q7TQN3
    Conserved Domains (6) summary
    cd05765
    Location:219299
    Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
    cd00104
    Location:133169
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00109
    Location:323374
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cd03575
    Location:450558
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam00014
    Location:380431
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:3786
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
  2. XM_006533500.5XP_006533563.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006533563.1

    UniProtKB/Swiss-Prot
    Q5SUS5, Q7TQN3
    Conserved Domains (6) summary
    cd05765
    Location:219299
    Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
    cd00104
    Location:133169
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00109
    Location:323374
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cd03575
    Location:450558
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam00014
    Location:380431
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:3786
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
  3. XM_006533497.5XP_006533560.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X1

    Conserved Domains (6) summary
    cd05765
    Location:233313
    Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
    cd00104
    Location:147183
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00109
    Location:337388
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cd03575
    Location:464572
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam00014
    Location:394445
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:51100
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
  4. XM_006533501.5XP_006533564.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006533564.1

    UniProtKB/Swiss-Prot
    Q5SUS5, Q7TQN3
    Conserved Domains (6) summary
    cd05765
    Location:219299
    Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
    cd00104
    Location:133169
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00109
    Location:323374
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cd03575
    Location:450558
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam00014
    Location:380431
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:3786
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
  5. XM_006533498.5XP_006533561.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006533561.1

    UniProtKB/Swiss-Prot
    Q5SUS5, Q7TQN3
    Conserved Domains (6) summary
    cd05765
    Location:219299
    Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
    cd00104
    Location:133169
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00109
    Location:323374
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cd03575
    Location:450558
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam00014
    Location:380431
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:3786
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
  6. XM_006533502.4XP_006533565.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006533565.1

    UniProtKB/Swiss-Prot
    Q5SUS5, Q7TQN3
    Conserved Domains (6) summary
    cd05765
    Location:219299
    Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
    cd00104
    Location:133169
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00109
    Location:323374
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cd03575
    Location:450558
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam00014
    Location:380431
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:3786
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
  7. XM_006533499.5XP_006533562.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006533562.1

    UniProtKB/Swiss-Prot
    Q5SUS5, Q7TQN3
    Conserved Domains (6) summary
    cd05765
    Location:219299
    Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
    cd00104
    Location:133169
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00109
    Location:323374
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cd03575
    Location:450558
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam00014
    Location:380431
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:3786
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'