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Zdhhc8 zinc finger, DHHC domain containing 8 [ Mus musculus (house mouse) ]

Gene ID: 27801, updated on 21-Apr-2024

Summary

Official Symbol
Zdhhc8provided by MGI
Official Full Name
zinc finger, DHHC domain containing 8provided by MGI
Primary source
MGI:MGI:1338012
See related
Ensembl:ENSMUSG00000060166 AllianceGenome:MGI:1338012
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DHHC-8; Op53c05; ZDHHCL1; D16H22S1738E; E330009O14Rik
Summary
Predicted to enable palmitoyltransferase activity. Acts upstream of or within locomotory behavior. Located in mitochondrion. Is expressed in several structures, including brain; cardiovascular system; forelimb bud; ganglia; and nose. Orthologous to human ZDHHC8 (zinc finger DHHC-type palmitoyltransferase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 67.5), ovary adult (RPKM 44.5) and 24 other tissues See more
Orthologs
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Genomic context

Location:
16 A3; 16 11.29 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18038612..18056471, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18220748..18235153, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933432I09 gene Neighboring gene coiled-coil domain containing 188 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:18231149-18231350 Neighboring gene predicted gene, 25777 Neighboring gene RAN binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E8621 Neighboring gene TRM2 tRNA methyltransferase 2A Neighboring gene DGCR8, microprocessor complex subunit

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC7847, MGC103030, MGC118171

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IEP
Inferred from Expression Pattern
more info
PubMed 

General protein information

Preferred Names
palmitoyltransferase ZDHHC8
Names
DHHC-containing protein 8
probable palmitoyltransferase ZDHHC8
zinc finger DHHC domain-containing protein 8
NP_001365948.1
NP_742163.4
XP_006522287.1
XP_036015869.1
XP_036015870.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379019.1NP_001365948.1  palmitoyltransferase ZDHHC8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC084822, AC118542
    UniProtKB/TrEMBL
    Q2TGE7
    Conserved Domains (1) summary
    pfam01529
    Location:99224
    DHHC; DHHC palmitoyltransferase
  2. NM_172151.4NP_742163.4  palmitoyltransferase ZDHHC8 isoform 1

    See identical proteins and their annotated locations for NP_742163.4

    Status: VALIDATED

    Source sequence(s)
    AY668947, AY894892
    Consensus CDS
    CCDS28017.1
    UniProtKB/Swiss-Prot
    Q5Y5T5, Q7TNF7
    UniProtKB/TrEMBL
    Q2TGE7
    Related
    ENSMUSP00000076224.6, ENSMUST00000076957.7
    Conserved Domains (1) summary
    pfam01529
    Location:99224
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    18038612..18056471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522224.5XP_006522287.1  palmitoyltransferase ZDHHC8 isoform X1

    See identical proteins and their annotated locations for XP_006522287.1

    UniProtKB/TrEMBL
    Q2TGE7
    Conserved Domains (1) summary
    cl19890
    Location:28171
    DHHC; DHHC palmitoyltransferase
  2. XM_036159976.1XP_036015869.1  palmitoyltransferase ZDHHC8 isoform X2

  3. XM_036159977.1XP_036015870.1  palmitoyltransferase ZDHHC8 isoform X3