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Depdc5 DEP domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 277854, updated on 16-Sep-2019

Summary

Official Symbol
Depdc5provided by MGI
Official Full Name
DEP domain containing 5provided by MGI
Primary source
MGI:MGI:2141101
See related
Ensembl:ENSMUSG00000037426
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AV016528
Expression
Ubiquitous expression in cerebellum adult (RPKM 5.6), whole brain E14.5 (RPKM 5.6) and 28 other tissues See more
Orthologs

Genomic context

See Depdc5 in Genome Data Viewer
Location:
5 B1; 5 17.35 cM
Exon count:
46
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (32863646..32994233)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (33206370..33336882)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene 2420 Neighboring gene phosphatidylserine decarboxylase Neighboring gene proline rich 14-like Neighboring gene ribosomal protein L37 pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide Neighboring gene predicted gene, 29892

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Chemically induced (ENU) (2) 
  • Endonuclease-mediated (1)  1 citation

Pathways from BioSystems

  • mTOR signaling pathway, organism-specific biosystem (from KEGG)
    mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
  • mTOR signaling pathway, conserved biosystem (from KEGG)
    mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

General gene information

Markers

Homology

Clone Names

  • KIAA0645

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
GATOR1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GATOR1 complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
GATOR complex protein DEPDC5
Names
DEP domain-containing protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025426.2NP_001020597.1  GATOR complex protein DEPDC5 isoform 1

    See identical proteins and their annotated locations for NP_001020597.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC122203, BC072604
    Consensus CDS
    CCDS19196.1
    UniProtKB/TrEMBL
    Q6GQV2
    Related
    ENSMUSP00000085207.4, ENSMUST00000087897.10
    Conserved Domains (2) summary
    cd04449
    Location:11761257
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:107381
    DUF3608; Protein of unknown function (DUF3608)
  2. NM_001170567.1NP_001164038.1  GATOR complex protein DEPDC5 isoform 3

    See identical proteins and their annotated locations for NP_001164038.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, uses an alternate in-frame splice site and includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AC122203, AK052458, BC072604, CX568961
    Consensus CDS
    CCDS51463.1
    UniProtKB/Swiss-Prot
    P61460
    UniProtKB/TrEMBL
    Q6GQV2
    Related
    ENSMUSP00000113862.1, ENSMUST00000119705.7
    Conserved Domains (2) summary
    cd04449
    Location:11671248
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:107381
    DUF3608; Protein of unknown function (DUF3608)
  3. NM_001360014.1NP_001346943.1  GATOR complex protein DEPDC5 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and lacks three alternate exons compared to variant 1. The resulting isoform (4) is shorter at the N-terminus, has a shorter and distinct C-terminus, and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC108773, AC122203
    Conserved Domains (2) summary
    cd04449
    Location:9761057
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:1212
    IML1; Vacuolar membrane-associated protein Iml1
  4. NM_177786.4NP_808454.2  GATOR complex protein DEPDC5 isoform 2

    See identical proteins and their annotated locations for NP_808454.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC122203, AK078771, AK136321, BC072604
    Consensus CDS
    CCDS19197.1
    UniProtKB/TrEMBL
    E9QAT3, Q6GQV2, Q8BVE2
    Related
    ENSMUSP00000052807.6, ENSMUST00000049780.12
    Conserved Domains (1) summary
    pfam12257
    Location:107381
    DUF3608; Protein of unknown function (DUF3608)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p6 C57BL/6J

    Range
    32863646..32994233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503983.4XP_006504046.1  GATOR complex protein DEPDC5 isoform X1

    See identical proteins and their annotated locations for XP_006504046.1

    Conserved Domains (2) summary
    cd04449
    Location:11761257
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:107381
    DUF3608; Protein of unknown function (DUF3608)
  2. XM_006503980.3XP_006504043.1  GATOR complex protein DEPDC5 isoform X1

    See identical proteins and their annotated locations for XP_006504043.1

    Conserved Domains (2) summary
    cd04449
    Location:11761257
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:107381
    DUF3608; Protein of unknown function (DUF3608)
  3. XM_030254553.1XP_030110413.1  GATOR complex protein DEPDC5 isoform X6

  4. XM_006503981.4XP_006504044.1  GATOR complex protein DEPDC5 isoform X1

    See identical proteins and their annotated locations for XP_006504044.1

    Conserved Domains (2) summary
    cd04449
    Location:11761257
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:107381
    DUF3608; Protein of unknown function (DUF3608)
  5. XM_030254550.1XP_030110410.1  GATOR complex protein DEPDC5 isoform X2

  6. XM_030254554.1XP_030110414.1  GATOR complex protein DEPDC5 isoform X6

  7. XM_017320910.1XP_017176399.1  GATOR complex protein DEPDC5 isoform X8

  8. XM_006503986.3XP_006504049.1  GATOR complex protein DEPDC5 isoform X4

    Conserved Domains (2) summary
    cd04449
    Location:11541235
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:107381
    DUF3608; Protein of unknown function (DUF3608)
  9. XM_006503978.3XP_006504041.1  GATOR complex protein DEPDC5 isoform X1

    See identical proteins and their annotated locations for XP_006504041.1

    Conserved Domains (2) summary
    cd04449
    Location:11761257
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:107381
    DUF3608; Protein of unknown function (DUF3608)
  10. XM_006503985.3XP_006504048.1  GATOR complex protein DEPDC5 isoform X3

    Conserved Domains (2) summary
    cd04449
    Location:11541235
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:107381
    DUF3608; Protein of unknown function (DUF3608)
  11. XM_006503984.3XP_006504047.1  GATOR complex protein DEPDC5 isoform X2

    See identical proteins and their annotated locations for XP_006504047.1

    UniProtKB/Swiss-Prot
    P61460
    Conserved Domains (2) summary
    cd04449
    Location:11671248
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:107381
    DUF3608; Protein of unknown function (DUF3608)
  12. XM_006503987.3XP_006504050.1  GATOR complex protein DEPDC5 isoform X5

    UniProtKB/Swiss-Prot
    P61460
    Related
    ENSMUSP00000113980.1, ENSMUST00000120902.7
    Conserved Domains (2) summary
    cd04449
    Location:11451226
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:107381
    DUF3608; Protein of unknown function (DUF3608)
  13. XM_030254552.1XP_030110412.1  GATOR complex protein DEPDC5 isoform X6

  14. XM_006503979.3XP_006504042.1  GATOR complex protein DEPDC5 isoform X1

    See identical proteins and their annotated locations for XP_006504042.1

    Conserved Domains (2) summary
    cd04449
    Location:11761257
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:107381
    DUF3608; Protein of unknown function (DUF3608)
  15. XM_006503982.3XP_006504045.1  GATOR complex protein DEPDC5 isoform X1

    See identical proteins and their annotated locations for XP_006504045.1

    Conserved Domains (2) summary
    cd04449
    Location:11761257
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:107381
    DUF3608; Protein of unknown function (DUF3608)
  16. XM_006503988.3XP_006504051.1  GATOR complex protein DEPDC5 isoform X6

    Conserved Domains (2) summary
    cd04449
    Location:10071088
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:1212
    DUF3608; Protein of unknown function (DUF3608)
  17. XM_030254555.1XP_030110415.1  GATOR complex protein DEPDC5 isoform X6

  18. XM_030254556.1XP_030110416.1  GATOR complex protein DEPDC5 isoform X7

  19. XM_017320908.1XP_017176397.1  GATOR complex protein DEPDC5 isoform X1

    Conserved Domains (2) summary
    cd04449
    Location:11761257
    DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
    pfam12257
    Location:107381
    DUF3608; Protein of unknown function (DUF3608)
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