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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_016194.2 RefSeqGene
- Range
-
5009..76453
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_000516.7 → NP_000507.1 protein GNAS isoform GNASL
See identical proteins and their annotated locations for NP_000507.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) is biallelically expressed and encodes guanine nucleotide binding protein alpha s long (GNASL), also known as alpha-S2, a form of the G-protein alpha subunit.
- Source sequence(s)
-
AF105253, AF493897, BC008855, BU857975
- Consensus CDS
-
CCDS13472.1
- UniProtKB/Swiss-Prot
- O95467, P63092, Q96H70
- UniProtKB/TrEMBL
-
A0A0S2Z3H8
- Related
- ENSP00000360126.3, ENST00000371085.8
- Conserved Domains (1) summary
-
- cd00066
Location:41 → 388
- G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
-
NM_001077488.5 → NP_001070956.1 protein GNAS isoform f
See identical proteins and their annotated locations for NP_001070956.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) is biallelically expressed and uses an alternate in frame splice site, compared to variant 1. It encodes isoform f which has an additional amino acid in the internal region compared to isoform GNASL.
- Source sequence(s)
-
AF105253, AF493897, BC008855, BC089157, M14631
- Consensus CDS
-
CCDS46623.1
- UniProtKB/Swiss-Prot
- O95467, P63092
- UniProtKB/TrEMBL
-
Q5FWY2
- Related
- ENSP00000346328.7, ENST00000354359.12
- Conserved Domains (1) summary
-
- cd00066
Location:41 → 389
- G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
-
NM_001077489.4 → NP_001070957.1 protein GNAS isoform g
See identical proteins and their annotated locations for NP_001070957.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) is biallelically expressed and lacks an alternate in-frame coding exon, compared to variant 1. It encodes isoform g, which lacks an internal segment, compared to isoform GNASL.
- Source sequence(s)
-
AF105253, AF493897, BC066923, BC089157
- Consensus CDS
-
CCDS42892.1
- UniProtKB/Swiss-Prot
- O95467, P63092
- UniProtKB/TrEMBL
-
Q5FWY2
- Related
- ENSP00000265620.7, ENST00000265620.11
- Conserved Domains (1) summary
-
- cd00066
Location:41 → 373
- G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
-
NM_001077490.3 → NP_001070958.1 protein ALEX isoform Alex
See identical proteins and their annotated locations for NP_001070958.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2, also known as GNASXL), is paternally expressed and includes an alternate 5' exon, compared to variant 1. This variant includes two overlapping ORFs encoding XLas and Alex, respectively. This RefSeq represents Alex (also known as alexX), which has no similarity to other proteins encoded by this gene. It interacts with XLas, and their interaction is essential for G-protein signaling in neuroendocrine cells.
- Source sequence(s)
-
AL132655, BQ029639, X04408
- UniProtKB/Swiss-Prot
- A2A2S4, P63092, P84996
- Conserved Domains (1) summary
-
- PHA03247
Location:125 → 345
- PHA03247; large tegument protein UL36; Provisional
-
NM_001309840.2 → NP_001296769.1 protein ALEX isoform h
See identical proteins and their annotated locations for NP_001296769.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (9) is paternally expressed, contains an alternate 5' terminal exon (A/B or Exon 1A) and uses a downstream start codon, compared to variant 1. Variants 9 and 11 encode the same isoform h (described in PMID:21713996), which has a shorter N-terminus, compared to isoform GNASL.
- Source sequence(s)
-
AL537118, CN403086, X04408, X56009
- Consensus CDS
-
CCDS93068.1
- UniProtKB/Swiss-Prot
-
P63092
- UniProtKB/TrEMBL
- B0AZR9, Q14455, S4R3V9
- Related
- ENSP00000499660.1, ENST00000477931.5
- Conserved Domains (1) summary
-
- cd00066
Location:1 → 329
- G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
-
NM_001309842.2 → NP_001296771.1 protein ALEX isoform i
Status: REVIEWED
- Description
- Transcript Variant: This variant (10) contains an alternate 3' exon structure, compared to variant 1. It encodes isoform i, which has a shorter and distinct C-terminus, compared to isoform GNASL.
- Source sequence(s)
-
AA948160, BC089157, BF800576, BF879848, CB530031, DB483472
- Consensus CDS
-
CCDS82633.1
- UniProtKB/TrEMBL
- Q5FWY2, Q5JWD1
- Related
- ENSP00000360122.1, ENST00000371081.5
- Conserved Domains (1) summary
-
- smart00275
Location:20 → 71
- G_alpha; G protein alpha subunit
-
NM_001309861.2 → NP_001296790.1 protein ALEX isoform h
See identical proteins and their annotated locations for NP_001296790.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (11) contains an alternate 5' terminal exon, compared to variant 1. Variants 9 and 11 encode the same isoform h (described in PMID:21713996), which has a shorter N-terminus, compared to isoform GNASL.
- Source sequence(s)
-
AF105253, AK315874, CN273438
- Consensus CDS
-
CCDS93068.1
- UniProtKB/Swiss-Prot
-
O95467
- UniProtKB/TrEMBL
- B0AZR9, S4R3V9
- Related
- ENSP00000499673.2, ENST00000472183.6
- Conserved Domains (1) summary
-
- cd00066
Location:1 → 329
- G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
-
NM_001309883.1 → NP_001296812.1 protein ALEX isoform Alex
See identical proteins and their annotated locations for NP_001296812.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (12) contains an alternate 5' exon structure compared to variant 1. It encodes the protein Alex (also known as alexX), which has no similarity to other proteins encoded by this gene. It interacts with XLas, and their interaction is essential for G-protein signaling in neuroendocrine cells. Variants 2 and 12 encode the same protein (Alex).
- Source sequence(s)
-
AA948160, AJ224867, AL132655, BF800576, BF879848
- UniProtKB/Swiss-Prot
- A2A2S4, P84996, Q5JWF2
- Related
- ENSP00000302237.4, ENST00000306120.4
- Conserved Domains (1) summary
-
- PHA03247
Location:125 → 345
- PHA03247; large tegument protein UL36; Provisional
-
NM_001410912.1 → NP_001397841.1 protein ALEX isoform j
Status: REVIEWED
- Source sequence(s)
-
AL109840, AL121917, AL132655
- Consensus CDS
-
CCDS93063.1
- UniProtKB/TrEMBL
-
A0A0A0MR13
-
NM_001410913.1 → NP_001397842.1 protein ALEX isoform k
Status: REVIEWED
- Source sequence(s)
-
AL109840, AL121917, AL132655
- Consensus CDS
-
CCDS93066.1
- UniProtKB/TrEMBL
-
Q5JWE9
-
NM_016592.5 → NP_057676.1 protein SCG6 (secretogranin VI) isoform SCG6
See identical proteins and their annotated locations for NP_057676.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) is maternally expressed and encodes secretogranin VI (SCG6, also known as NESP55), which localizes to large secretory vesicles of endocrine cells and neurons. Its coding region is within the 5'-most exon and does not overlap the coding regions used by other transcripts; thus SCG6 has no similarity to isoforms of the G-protein alpha subunit. This variant has an antisense transcript, GNAS-AS1.
- Source sequence(s)
-
AF105253, AL132655, BC008855, BC036081
- Consensus CDS
-
CCDS13471.1
- UniProtKB/Swiss-Prot
- O95417, O95467
- Related
- ENSP00000360115.3, ENST00000371075.7
- Conserved Domains (1) summary
-
- pfam06390
Location:1 → 245
- NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
-
NM_080425.4 → NP_536350.2 protein GNAS isoform XLas
See identical proteins and their annotated locations for NP_536350.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2, also known as GNASXL) is paternally expressed and includes an alternate 5' exon, compared to variant 1. This variant includes two overlapping open reading frames encoding isoforms XLas and Alex, respectively. This RefSeq represents isoform XLas (also known as alpha sXXL), which is a neuroendocrine-specific G-protein alpha subunit. The encoded isoform has a distinct and longer N-terminus, compared to isoform GNASL. Variants 2 and 12 both encode the same isoform (Alex).
- Source sequence(s)
-
AL132655, BQ029639, CN295544, X04408
- Consensus CDS
-
CCDS46622.1
- UniProtKB/Swiss-Prot
- P63092, Q5JWF2, Q9NY42
- Related
- ENSP00000360141.3, ENST00000371100.9
- Conserved Domains (2) summary
-
- cd00066
Location:684 → 1031
- G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
- smart00275
Location:663 → 1034
- G_alpha; G protein alpha subunit
-
NM_080426.4 → NP_536351.1 protein GNAS isoform GNASS
See identical proteins and their annotated locations for NP_536351.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) is biallelically expressed. It lacks an internal exon and uses an alternate splice site, compared to variant 1. It encodes isoform GNASS, also known as alpha-S1, which differs in an internal region and has identical N- and C-termini, compared to isoform GNASL.
- Source sequence(s)
-
AF105253, AF493897, BC089157
- Consensus CDS
-
CCDS46624.1
- UniProtKB/Swiss-Prot
- O95467, P63092
- UniProtKB/TrEMBL
- A0A0S2Z3S5, Q5FWY2
- Related
- ENSP00000360136.3, ENST00000371095.7
- Conserved Domains (1) summary
-
- cd00066
Location:41 → 374
- G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
RNA
-
NR_132272.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (13) contains alternate 5' and 3' terminal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
- Source sequence(s)
-
AA948160, AL121917, BF800576, BF879848, HY141824
-
NR_132273.1 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (14) contains alternate 5' and 3' terminal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
- Source sequence(s)
-
AA948160, AL121917, AV751821, BF800576, BF879848, BM894355
- Related
-
ENST00000464960.5
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000020.11 Reference GRCh38.p14 Primary Assembly
- Range
-
58839748..58911192
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047440113.1 → XP_047296069.1 protein ALEX isoform X3
-
XM_017027815.2 → XP_016883304.1 protein ALEX isoform X4
- Conserved Domains (1) summary
-
- cd00066
Location:5 → 341
- G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
-
XM_047440114.1 → XP_047296070.1 protein GNAS isoform X5
- UniProtKB/TrEMBL
-
A0A590UJR6
- Related
- ENSP00000499353.2, ENST00000663479.2
-
XM_047440122.1 → XP_047296078.1 protein ALEX isoform X8
- UniProtKB/TrEMBL
-
A0A590UKA4
- Related
- ENSP00000499794.2, ENST00000482112.6
-
XM_017027812.3 → XP_016883301.1 protein GNAS isoform X1
- UniProtKB/TrEMBL
-
A0A7I2V5R6
- Related
- ENSP00000504675.2, ENST00000676826.2
-
XM_017027813.3 → XP_016883302.1 protein GNAS isoform X2
- UniProtKB/Swiss-Prot
-
Q5JWF2
- Related
- ENSP00000360143.4, ENST00000371102.8
-
XM_047440121.1 → XP_047296077.1 protein ALEX isoform X8
- UniProtKB/TrEMBL
-
A0A590UKA4
-
XM_047440125.1 → XP_047296081.1 protein GNAS isoform X5
- UniProtKB/TrEMBL
-
A0A590UJR6
- Related
- ENSP00000499552.2, ENST00000470512.6
-
XM_047440118.1 → XP_047296074.1 protein GNAS isoform X7
- UniProtKB/TrEMBL
-
A0A590UKB4
- Related
- ENSP00000499762.2, ENST00000478585.6
-
XM_017027817.2 → XP_016883306.1 protein ALEX isoform X8
- UniProtKB/TrEMBL
-
A0A590UKA4
- Related
- ENSP00000499392.1, ENST00000480975.5
- Conserved Domains (1) summary
-
- cd00066
Location:1 → 314
- G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
-
XM_047440117.1 → XP_047296073.1 protein GNAS isoform X5
- UniProtKB/TrEMBL
-
A0A590UJR6
-
XM_024451875.2 → XP_024307643.1 protein ALEX isoform X6
- UniProtKB/TrEMBL
-
S4R3V9
- Related
- ENSP00000474219.2, ENST00000604005.6
- Conserved Domains (1) summary
-
- cd00066
Location:1 → 329
- G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
-
XM_047440120.1 → XP_047296076.1 protein GNAS isoform X7
- UniProtKB/TrEMBL
-
A0A590UKB4
-
XM_017027819.2 → XP_016883308.1 protein ALEX isoform X8
- UniProtKB/TrEMBL
-
A0A590UKA4
- Conserved Domains (1) summary
-
- cd00066
Location:1 → 314
- G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
-
XM_047440116.1 → XP_047296072.1 protein GNAS isoform X5
- UniProtKB/TrEMBL
-
A0A590UJR6
-
XM_047440123.1 → XP_047296079.1 protein ALEX isoform X8
- UniProtKB/TrEMBL
-
A0A590UKA4
-
XM_047440115.1 → XP_047296071.1 protein GNAS isoform X5
- UniProtKB/TrEMBL
-
A0A590UJR6
-
XM_024451873.2 → XP_024307641.1 protein ALEX isoform X6
- UniProtKB/TrEMBL
-
S4R3V9
- Related
- ENSP00000499435.2, ENST00000488652.6
- Conserved Domains (1) summary
-
- cd00066
Location:1 → 329
- G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
-
XM_047440119.1 → XP_047296075.1 protein GNAS isoform X7
- UniProtKB/TrEMBL
-
A0A590UKB4
- Related
- ENSP00000499443.2, ENST00000492907.6
-
XM_017027818.3 → XP_016883307.1 protein ALEX isoform X8
- UniProtKB/TrEMBL
-
A0A590UKA4
- Related
- ENSP00000499409.2, ENST00000476935.6
- Conserved Domains (1) summary
-
- cd00066
Location:1 → 314
- G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
-
XM_017027820.1 → XP_016883309.1 protein ALEX isoform X9
- Conserved Domains (1) summary
-
- cd00066
Location:11 → 314
- G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
-
XM_047440124.1 → XP_047296080.1 protein ALEX isoform X9
Alternate T2T-CHM13v2.0
Genomic
-
NC_060944.1 Alternate T2T-CHM13v2.0
- Range
-
60622888..60694319
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054323370.1 → XP_054179345.1 protein ALEX isoform X3
-
XM_054323371.1 → XP_054179346.1 protein ALEX isoform X4
-
XM_054323372.1 → XP_054179347.1 protein GNAS isoform X5
- UniProtKB/TrEMBL
-
A0A590UJR6
-
XM_054323378.1 → XP_054179353.1 protein ALEX isoform X8
- UniProtKB/TrEMBL
-
A0A590UKA4
-
XM_054323365.1 → XP_054179340.1 protein GNAS isoform X1
- UniProtKB/TrEMBL
-
A0A7I2V5R6
-
XM_054323366.1 → XP_054179341.1 protein GNAS isoform X2
-
XM_054323367.1 → XP_054179342.1 protein GNAS isoform X5
- UniProtKB/TrEMBL
-
A0A590UJR6
-
XM_054323368.1 → XP_054179343.1 protein GNAS isoform X7
- UniProtKB/TrEMBL
-
A0A590UKB4
-
XM_054323369.1 → XP_054179344.1 protein ALEX isoform X8
- UniProtKB/TrEMBL
-
A0A590UKA4
-
XM_054323373.1 → XP_054179348.1 protein GNAS isoform X5
- UniProtKB/TrEMBL
-
A0A590UJR6
-
XM_054323374.1 → XP_054179349.1 protein ALEX isoform X6
- UniProtKB/TrEMBL
-
S4R3V9
-
XM_054323375.1 → XP_054179350.1 protein GNAS isoform X7
- UniProtKB/TrEMBL
-
A0A590UKB4
-
XM_054323376.1 → XP_054179351.1 protein ALEX isoform X8
- UniProtKB/TrEMBL
-
A0A590UKA4
-
XM_054323377.1 → XP_054179352.1 protein ALEX isoform X9