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Tcfl5 transcription factor-like 5 (basic helix-loop-helix) [ Mus musculus (house mouse) ]

Gene ID: 277353, updated on 22-Jan-2023

Summary

Official Symbol
Tcfl5provided by MGI
Official Full Name
transcription factor-like 5 (basic helix-loop-helix)provided by MGI
Primary source
MGI:MGI:2672878
See related
Ensembl:ENSMUSG00000038932 AllianceGenome:MGI:2672878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Figlb; Sosf1
Summary
Enables DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in male germ cell nucleus. Is expressed in brain. Orthologous to human TCFL5 (transcription factor like 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 76.6) See more
Orthologs
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Genomic context

See Tcfl5 in Genome Data Viewer
Location:
2; 2 H4
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180263749..180284484, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180621956..180642691, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 30144 Neighboring gene MRG/MORF4L binding protein Neighboring gene opioid growth factor receptor Neighboring gene collagen, type IX, alpha 3 Neighboring gene predicted gene, 54097 Neighboring gene death inducer-obliterator 1 Neighboring gene predicted gene, 22502 Neighboring gene GID complex subunit 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

General gene information

Markers

Homology

Clone Names

  • MGC118431

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription factor-like 5 protein
Names
FIG beta
factor in the germline beta
spermatogenesis- and oogenesis-specific bHLH-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360335.2NP_001347264.1  transcription factor-like 5 protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL669926, AL732560
  2. NM_001409509.1NP_001396438.1  transcription factor-like 5 protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL669926, AL732560
  3. NM_001409510.1NP_001396439.1  transcription factor-like 5 protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL669926, AL732560
  4. NM_001409511.1NP_001396440.1  transcription factor-like 5 protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL669926, AL732560
  5. NM_001409512.1NP_001396441.1  transcription factor-like 5 protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL669926, AL732560
  6. NM_178254.4NP_839985.2  transcription factor-like 5 protein isoform 2

    See identical proteins and their annotated locations for NP_839985.2

    Status: VALIDATED

    Source sequence(s)
    AL669926, AL732560
    Consensus CDS
    CCDS17181.2
    UniProtKB/TrEMBL
    Q32NY8
    Related
    ENSMUSP00000040611.11, ENSMUST00000037877.11

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    180263749..180284484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162274.1XP_036018167.1  transcription factor-like 5 protein isoform X1

    Conserved Domains (1) summary
    cl00081
    Location:390408
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily