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GNA15 G protein subunit alpha 15 [ Homo sapiens (human) ]

Gene ID: 2769, updated on 8-Feb-2025

Summary

Official Symbol
GNA15provided by HGNC
Official Full Name
G protein subunit alpha 15provided by HGNC
Primary source
HGNC:HGNC:4383
See related
Ensembl:ENSG00000060558 MIM:139314; AllianceGenome:HGNC:4383
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HG1L; GNA16
Summary
Enables G protein-coupled receptor binding activity. Acts upstream of or within with a positive effect on calcium-mediated signaling. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Feb 2025]
Expression
Biased expression in esophagus (RPKM 28.1), bone marrow (RPKM 27.9) and 13 other tissues See more
Orthologs
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Genomic context

See GNA15 in Genome Data Viewer
Location:
19p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (3136033..3163749)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (3111823..3140075)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3136031..3163747)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904615 Neighboring gene ribosomal protein L35 pseudogene 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3141544-3142044 Neighboring gene GNA15 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3154789-3155746 Neighboring gene Sharpr-MPRA regulatory region 13242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3163409-3164269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3176749-3177631 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13730 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:3185006-3185888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9832 Neighboring gene sphingosine-1-phosphate receptor 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3189343-3189846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3189847-3190350 Neighboring gene nicalin

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
guanine nucleotide-binding protein subunit alpha-15
Names
G-protein subunit alpha-16
epididymis secretory sperm binding protein
epididymis tissue protein Li 17E
g alpha-15
g alpha-16
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
guanine nucleotide-binding protein subunit alpha-16
heterotrimeric guanine nucleotide-binding protein 1L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002068.4NP_002059.3  guanine nucleotide-binding protein subunit alpha-15

    See identical proteins and their annotated locations for NP_002059.3

    Status: VALIDATED

    Source sequence(s)
    AC005262, BC013585, BQ015560
    Consensus CDS
    CCDS12104.1
    UniProtKB/Swiss-Prot
    E9KL40, E9KL47, O75247, P30679, Q53XK2
    UniProtKB/TrEMBL
    A0A384ME65, A8K5L4
    Related
    ENSP00000262958.2, ENST00000262958.4
    Conserved Domains (1) summary
    smart00275
    Location:22372
    G_alpha; G protein alpha subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    3136033..3163749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    3111823..3140075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)