rho-5 rhomboid-5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: rho-5provided by FlyBase
Official Full Name: rhomboid-5provided by FlyBase
Primary source: FLYBASE:FBgn0041723
Locus tag: Dmel_CG33304
See related: AllianceGenome:FB:FBgn0041723
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG33304; CG5364; CT17046; Dmel\CG33304; iRhom; iRhom1; Rho-related[31D10]
Summary: Involved in negative regulation of epidermal growth factor receptor signaling pathway and positive regulation of circadian sleep/wake cycle, wakefulness. Located in endoplasmic reticulum membrane. Is expressed in adult head; embryonic/larval optic lobe; eye disc posterior to the morphogenetic furrow; larval brain; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in palmoplantar keratoderma-esophageal carcinoma syndrome. Orthologous to human RHBDF1 (rhomboid 5 homolog 1) and RHBDF2 (rhomboid 5 homolog 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Try the new Transcripts and proteins table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10368025..10373900, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10368025..10373900, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
NOT enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, wakefulness	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein secretion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info