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CG42271 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 2768892, updated on 4-Jan-2025

Summary

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Official Symbol
CG42271provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0259166
Locus tag
Dmel_CG42271
See related
AllianceGenome:FB:FBgn0259166
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1846; CG33248; CG33249; Dmel\CG42271; FBgn0259166; INPP4A
Old locus tag
Dmel_CG33248; Dmel_CG33249
Summary
Predicted to enable phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. Predicted to be active in cytoplasm. Orthologous to human INPP4A (inositol polyphosphate-4-phosphatase type I A) and INPP4B (inositol polyphosphate-4-phosphatase type II B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG42271 in Genome Data Viewer
Location:
12E5-12E5; 1-48 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14228060..14234066, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14122093..14128099, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 16 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L38 Neighboring gene F box and leucine-rich-repeat gene 4 Neighboring gene Dihydrouridine synthase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Using Drosophila melanogaster to identify chemotherapy toxicity genes. King EG, et al. Genetics, 2014 Sep. PMID 25236447, Free PMC Article
  2. Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo. Wishart TM, et al. PLoS Genet, 2012. PMID 22952455, Free PMC Article
  3. Competition within Introns: Splicing Wins over Polyadenylation via a General Mechanism. Tikhonov M, et al. Acta Naturae, 2013 Oct. PMID 24455183, Free PMC Article
  4. Hypoxia controls plasma membrane targeting of polarity proteins by dynamic turnover of PI4P and PI(4,5)P2. Lu J, et al. Elife, 2022 Jun 9. PMID 35678383, Free PMC Article
  5. A conserved myotubularin-related phosphatase regulates autophagy by maintaining autophagic flux. Allen EA, et al. J Cell Biol, 2020 Nov 2. PMID 32915229, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG42271-PB
CG42271-PC
NP_996434.2
NP_996435.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    14228060..14234066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206711.3 → NP_996434.2  uncharacterized protein Dmel_CG42271, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996434.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VY47
    Conserved Domains (3) summary
    cd13272
    Location:1 → 145
    PH_INPP4A_INPP4B; Type I inositol 3,4-bisphosphate 4-phosphatase and Type II inositol 3,4-bisphosphate 4-phosphatase Pleckstrin homology (PH) domain
    pfam00169
    Location:21 → 123
    PH; PH domain
    cl14603
    Location:201 → 318
    C2; C2 domain

  2. NM_206712.2 → NP_996435.1  uncharacterized protein Dmel_CG42271, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996435.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MR65
    Conserved Domains (2) summary
    cd13272
    Location:1 → 145
    PH_INPP4A_INPP4B; Type I inositol 3,4-bisphosphate 4-phosphatase and Type II inositol 3,4-bisphosphate 4-phosphatase Pleckstrin homology (PH) domain
    pfam00169
    Location:21 → 123
    PH; PH domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MR65 Q8MR65
Q9VY47 Q9VY47

Gene LinkOut

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