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Pigs phosphatidylinositol glycan anchor biosynthesis, class S [ Mus musculus (house mouse) ]

Gene ID: 276846, updated on 6-Jun-2024

Summary

Official Symbol
Pigsprovided by MGI
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Sprovided by MGI
Primary source
MGI:MGI:2687325
See related
Ensembl:ENSMUSG00000041958 AllianceGenome:MGI:2687325
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm393; Gm689
Summary
Involved in attachment of GPI anchor to protein. Part of GPI-anchor transamidase complex. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human PIGS (phosphatidylinositol glycan anchor biosynthesis class S). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 76.5), ovary adult (RPKM 51.5) and 28 other tissues See more
Orthologs
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Genomic context

See Pigs in Genome Data Viewer
Location:
11 B5; 11 46.74 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78219272..78233602)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78328422..78342776)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9832 Neighboring gene sperm associated antigen 5 Neighboring gene STARR-positive B cell enhancer ABC_E906 Neighboring gene aldolase C, fructose-bisphosphate Neighboring gene unc-119 lipid binding chaperone Neighboring gene STARR-positive B cell enhancer mm9_chr11:78173491-78173792 Neighboring gene forkhead box N1 Neighboring gene predicted gene, 30367

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in attachment of GPI anchor to protein IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in attachment of GPI anchor to protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of GPI-anchor transamidase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of GPI-anchor transamidase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of GPI-anchor transamidase complex ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
GPI transamidase component PIG-S
Names
phosphatidylinositol glycan, class S homolog
phosphatidylinositol-glycan biosynthesis class S protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418218.1NP_001405147.1  GPI transamidase component PIG-S isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL591070
    UniProtKB/TrEMBL
    Q3U643, Q3V3K6
  2. NM_201406.2NP_958808.1  GPI transamidase component PIG-S isoform 1

    See identical proteins and their annotated locations for NP_958808.1

    Status: VALIDATED

    Source sequence(s)
    AL591070
    Consensus CDS
    CCDS25100.1
    UniProtKB/Swiss-Prot
    Q6PD26
    UniProtKB/TrEMBL
    Q3U643, Q3V307
    Related
    ENSMUSP00000044871.9, ENSMUST00000048073.9
    Conserved Domains (1) summary
    pfam10510
    Location:22546
    PIG-S; Phosphatidylinositol-glycan biosynthesis class S protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    78219272..78233602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)