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Eif5a eukaryotic translation initiation factor 5A [ Mus musculus (house mouse) ]

Gene ID: 276770, updated on 8-Jan-2023

Summary

Official Symbol
Eif5aprovided by MGI
Official Full Name
eukaryotic translation initiation factor 5Aprovided by MGI
Primary source
MGI:MGI:106248
See related
Ensembl:ENSMUSG00000078812 AllianceGenome:MGI:106248
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eif4d; Eif5a1; eIF-4D; eIF-5A; eIF-5A1; eIF-5A-1; D19Wsu54e
Summary
This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in liver E14 (RPKM 325.9), liver E14.5 (RPKM 312.4) and 28 other tissues See more
Orthologs
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Genomic context

See Eif5a in Genome Data Viewer
Location:
11; 11 B3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69807538..69812784, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69916712..69921958, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2810408A11 gene Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene G protein pathway suppressor 2 Neighboring gene Y box protein 2 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC6725

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables U6 snRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
 
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in annulate lamellae ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 5A-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166589.1NP_001160061.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160061.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also referred to as variant BD) represents the longest transcript. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK010183, AK011306, AK218644, AL596185, CX237346
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242
    UniProtKB/TrEMBL
    A0A6P5QRS9, A0A8C6HTR1
    Related
    ENSMUSP00000047008.4, ENSMUST00000043419.10
    Conserved Domains (1) summary
    cl30809
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
  2. NM_001166590.1NP_001160062.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160062.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also referred to as variant D) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK011306, AK218644, AL596185, CX237346
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242
    UniProtKB/TrEMBL
    A0A6P5QRS9, A0A8C6HTR1
    Related
    ENSMUSP00000104250.2, ENSMUST00000108610.8
    Conserved Domains (1) summary
    cl30809
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
  3. NM_001166591.1NP_001160063.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160063.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also referred to as variant BE) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK010183, AK011306, AK218644, AL596185
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242
    UniProtKB/TrEMBL
    A0A6P5QRS9, A0A8C6HTR1
    Related
    ENSMUSP00000067077.5, ENSMUST00000070996.11
    Conserved Domains (1) summary
    cl30809
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
  4. NM_001166592.1NP_001160064.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160064.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also referred to as variant CD) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK011306, AK218644, CX218195, CX237346
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242
    UniProtKB/TrEMBL
    A0A6P5QRS9, A0A8C6HTR1
    Related
    ENSMUSP00000104251.2, ENSMUST00000108611.8
    Conserved Domains (1) summary
    cl30809
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
  5. NM_001166593.1NP_001160065.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160065.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also referred to as variant AE) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK011306, AK218644, AL596185
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242
    UniProtKB/TrEMBL
    A0A6P5QRS9, A0A8C6HTR1
    Related
    ENSMUSP00000068651.4, ENSMUST00000071026.10
    Conserved Domains (1) summary
    cl30809
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
  6. NM_001166594.1NP_001160066.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160066.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7, also referred to as variant C) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK011306, AK218644, CX218195, CX237346
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242
    UniProtKB/TrEMBL
    A0A6P5QRS9, A0A8C6HTR1
    Related
    ENSMUSP00000104252.2, ENSMUST00000108612.8
    Conserved Domains (1) summary
    cl30809
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
  7. NM_001166595.1NP_001160067.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160067.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK011306, AK218644, AL596185
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242
    UniProtKB/TrEMBL
    A0A6P5QRS9, A0A8C6HTR1
    Conserved Domains (1) summary
    cl30809
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
  8. NM_001166596.1NP_001160068.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160068.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK011306, AK218644, AL596185, CX237346
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242
    UniProtKB/TrEMBL
    A0A6P5QRS9, A0A8C6HTR1
    Related
    ENSMUSP00000132717.2, ENSMUST00000164359.8
    Conserved Domains (1) summary
    cl30809
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
  9. NM_181582.4NP_853613.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_853613.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also referred to as variant B) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK010183, AK011306, AK218644, AL596185
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242
    UniProtKB/TrEMBL
    A0A6P5QRS9, A0A8C6HTR1
    Related
    ENSMUSP00000104253.4, ENSMUST00000108613.10
    Conserved Domains (1) summary
    cl30809
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69807538..69812784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246050.2XP_030101910.1  eukaryotic translation initiation factor 5A-1 isoform X1

    UniProtKB/TrEMBL
    A0A6P5QRS9, A0A8C6HTR1
    Conserved Domains (1) summary
    cl30809
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
  2. XM_011249058.4XP_011247360.1  eukaryotic translation initiation factor 5A-1 isoform X1

    See identical proteins and their annotated locations for XP_011247360.1

    UniProtKB/Swiss-Prot
    P63242
    UniProtKB/TrEMBL
    A0A6P5QRS9, A0A8C6HTR1
    Related
    ENSMUSP00000104249.2, ENSMUST00000108609.8
    Conserved Domains (1) summary
    cl30809
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
  3. XM_030246051.1XP_030101911.1  eukaryotic translation initiation factor 5A-1 isoform X1

    UniProtKB/TrEMBL
    A0A6P5QRS9, A0A8C6HTR1
    Conserved Domains (1) summary
    cl30809
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
  4. XM_036156739.1XP_036012632.1  eukaryotic translation initiation factor 5A-1 isoform X1

    UniProtKB/TrEMBL
    A0A6P5QRS9, A0A8C6HTR1
    Conserved Domains (1) summary
    cl30809
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional