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Ubl4a ubiquitin-like 4A [ Mus musculus (house mouse) ]

Gene ID: 27643, updated on 12-May-2024

Summary

Official Symbol
Ubl4aprovided by MGI
Official Full Name
ubiquitin-like 4Aprovided by MGI
Primary source
MGI:MGI:95049
See related
Ensembl:ENSMUSG00000015290 AllianceGenome:MGI:95049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gdx; Ubl4; DXS254E; DXS254Eh; DXHXS254E
Summary
Predicted to enable chaperone binding activity. Predicted to be involved in tail-anchored membrane protein insertion into ER membrane. Predicted to be located in cytosol; membrane; and nucleoplasm. Predicted to be part of BAT3 complex. Is expressed in olfactory cortex ventricular layer; olfactory epithelium; and telencephalon ventricular layer. Orthologous to human UBL4A (ubiquitin like 4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 25.5), kidney adult (RPKM 22.3) and 28 other tissues See more
Orthologs
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Genomic context

See Ubl4a in Genome Data Viewer
Location:
X A7.3; X 38.0 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73409324..73412154, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74365718..74368548, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene plexin A3 Neighboring gene L antigen family, member 3 Neighboring gene predicted readthrough transcript (NMD candidate), 44504 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 3 Neighboring gene FAM3 metabolism regulating signaling molecule A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Readthrough Gm44504

Readthrough gene: Gm44504, Included gene: Slc10a3

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of BAT3 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of BAT3 complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquitin-like protein 4A
Names
housekeeping protein DXS254E
ubiquitin-like 4
ubiquitin-like protein GDX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145405.2NP_663380.1  ubiquitin-like protein 4A

    See identical proteins and their annotated locations for NP_663380.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
    Source sequence(s)
    AK048689, BM900115, BM932729, BY273712
    Consensus CDS
    CCDS30230.1
    UniProtKB/Swiss-Prot
    P21126
    UniProtKB/TrEMBL
    B2M0S0, Q3UK94
    Related
    ENSMUSP00000120461.2, ENSMUST00000155676.8
    Conserved Domains (2) summary
    cd01807
    Location:172
    Ubl_UBL4A_like; ubiquitin-like (Ubl) domain found in ubiquitin-like proteins UBL4A and similar proteins
    pfam17840
    Location:96142
    Tugs; Tethering Ubl4a to BAGS domain

RNA

  1. NR_045779.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a coding exon compared to variant 1, that causes a frameshift. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD), so it likely does not encode a protein.
    Source sequence(s)
    AK048689, BM900115, BM932729, BY107969, BY273712
    Related
    ENSMUST00000126117.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    73409324..73412154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)