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AMY1A amylase, alpha 1A (salivary) [ Homo sapiens (human) ]

Gene ID: 276, updated on 8-Dec-2018

Summary

Official Symbol
AMY1Aprovided by HGNC
Official Full Name
amylase, alpha 1A (salivary)provided by HGNC
Primary source
HGNC:HGNC:474
See related
Ensembl:ENSG00000237763 MIM:104700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMY1
Summary
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward salivary gland (RPKM 4834.2) See more

Genomic context

See AMY1A in Genome Data Viewer
Location:
1p21.1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (103655519..103664551)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (104193695..104207174)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene amylase, alpha 2B (pancreatic) Neighboring gene actin gamma 1 pseudogene 4 Neighboring gene amylase, alpha 2A (pancreatic) Neighboring gene uncharacterized LOC105378878 Neighboring gene amylase, alpha 1B (salivary)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Carbohydrate digestion and absorption, organism-specific biosystem (from KEGG)
    Carbohydrate digestion and absorption, organism-specific biosystemDietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates. These carbohydrates are digested t...
  • Carbohydrate digestion and absorption, conserved biosystem (from KEGG)
    Carbohydrate digestion and absorption, conserved biosystemDietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates. These carbohydrates are digested t...
  • Digestion of dietary carbohydrate, organism-specific biosystem (from REACTOME)
    Digestion of dietary carbohydrate, organism-specific biosystemCarbohydrate is a major component of the human diet, and includes starch (amylose and amylopectin) and disaccharides such as sucrose, lactose, maltose and, in small amounts, trehalose. The digestion ...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
  • Salivary secretion, organism-specific biosystem (from KEGG)
    Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Salivary secretion, conserved biosystem (from KEGG)
    Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Starch and sucrose metabolism, organism-specific biosystem (from KEGG)
    Starch and sucrose metabolism, organism-specific biosystem
    Starch and sucrose metabolism
  • Starch and sucrose metabolism, conserved biosystem (from KEGG)
    Starch and sucrose metabolism, conserved biosystem
    Starch and sucrose metabolism

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alpha-amylase activity IEA
Inferred from Electronic Annotation
more info
 
alpha-amylase activity (releasing maltohexaose) IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-amylase 1
Names
1,4-alpha-D-glucan glucanohydrolase 1
amylase, salivary, alpha-1A
glycogenase
salivary alpha-amylase
salivary amylase alpha 1A
NP_001008222.1
NP_004029.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008221.1NP_001008222.1  alpha-amylase 1 precursor

    See identical proteins and their annotated locations for NP_001008222.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC063129, BC070302, BX487266
    Consensus CDS
    CCDS30782.1
    UniProtKB/Swiss-Prot
    P04745
    UniProtKB/TrEMBL
    Q6NSB3
    Conserved Domains (3) summary
    cd11317
    Location:25416
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:422510
    Aamy_C; Aamy_C domain
    COG0366
    Location:46315
    AmyA; Glycosidase [Carbohydrate transport and metabolism]
  2. NM_004038.3NP_004029.2  alpha-amylase 1 precursor

    See identical proteins and their annotated locations for NP_004029.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC063129, BC070302, CB956272
    Consensus CDS
    CCDS30782.1
    UniProtKB/Swiss-Prot
    P04745
    UniProtKB/TrEMBL
    Q6NSB3
    Related
    ENSP00000359100.4, ENST00000370083.8
    Conserved Domains (3) summary
    cd11317
    Location:25416
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:422510
    Aamy_C; Aamy_C domain
    COG0366
    Location:46315
    AmyA; Glycosidase [Carbohydrate transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    103655519..103664551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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