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GLUD2 glutamate dehydrogenase 2 [ Homo sapiens (human) ]

Gene ID: 2747, updated on 11-Jun-2021

Summary

Official Symbol
GLUD2provided by HGNC
Official Full Name
glutamate dehydrogenase 2provided by HGNC
Primary source
HGNC:HGNC:4336
See related
Ensembl:ENSG00000182890 MIM:300144
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GDH2; GLUDP1
Summary
The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010]
Orthologs
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Genomic context

See GLUD2 in Genome Data Viewer
Location:
Xq24
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (121047610..121050094)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (120181464..120183948)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373328 Neighboring gene cancer/testis antigen family 47 member A1 Neighboring gene CBLL1 pseudogene 1 Neighboring gene uncharacterized LOC112268302 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 1 Neighboring gene microRNA 3672

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of glutamate dehydrogenase 2 (GLUD2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables glutamate dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutamate dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutamate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 
enables glutamate dehydrogenase [NAD(P)+] activity IDA
Inferred from Direct Assay
more info
PubMed 
enables leucine binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in glutamate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glutamate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glutamate catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glutamate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
NOT located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glutamate dehydrogenase 2, mitochondrial
Names
GDH 2
glutamate dehydrogenase pseudogene 1
testicular secretory protein Li 14
NP_036216.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016456.1 RefSeqGene

    Range
    5003..7487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012084.4NP_036216.2  glutamate dehydrogenase 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_036216.2

    Status: REVIEWED

    Source sequence(s)
    AC006144, BC050732
    Consensus CDS
    CCDS14603.1
    UniProtKB/Swiss-Prot
    P49448
    UniProtKB/TrEMBL
    A0A140VK14
    Related
    ENSP00000327589.1, ENST00000328078.3
    Conserved Domains (3) summary
    cd01076
    Location:263548
    NAD_bind_1_Glu_DH; NAD(P) binding domain of glutamate dehydrogenase, subgroup 1
    COG0334
    Location:104555
    GdhA; Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]
    pfam02812
    Location:113240
    ELFV_dehydrog_N; Glu/Leu/Phe/Val dehydrogenase, dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    121047610..121050094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160027.1 Reference GRCh38.p13 PATCHES

    Range
    367013..369497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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