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MAT2B methionine adenosyltransferase 2B [ Homo sapiens (human) ]

Gene ID: 27430, updated on 17-Jun-2019

Summary

Official Symbol
MAT2Bprovided by HGNC
Official Full Name
methionine adenosyltransferase 2Bprovided by HGNC
Primary source
HGNC:HGNC:6905
See related
Ensembl:ENSG00000038274 MIM:605527
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TGR; MAT-II; SDR23E1; MATIIbeta; Nbla02999
Summary
The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in lymph node (RPKM 45.7), thyroid (RPKM 43.7) and 25 other tissues See more
Orthologs

Genomic context

See MAT2B in Genome Data Viewer
Location:
5q34
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (163503064..163519354)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (162930070..162946359)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene cyclin G1 Neighboring gene NudC domain containing 2 Neighboring gene hyaluronan mediated motility receptor Neighboring gene HMMR antisense RNA 1 Neighboring gene uncharacterized LOC102724458 Neighboring gene RNA, U6 small nuclear 168, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
NHGRI GWA Catalog
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
NHGRI GWA Catalog
Genome-wide association study of smoking behaviours among Bangladeshi adults.
NHGRI GWA Catalog
Linkage and association of successful aging to the 6q25 region in large Amish kindreds.
NHGRI GWA Catalog

Pathways from BioSystems

  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Biosynthesis of amino acids, organism-specific biosystem (from KEGG)
    Biosynthesis of amino acids, organism-specific biosystemThis map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module fo...
  • Biosynthesis of amino acids, conserved biosystem (from KEGG)
    Biosynthesis of amino acids, conserved biosystemThis map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module fo...
  • Cysteine and methionine metabolism, organism-specific biosystem (from KEGG)
    Cysteine and methionine metabolism, organism-specific biosystemCysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted f...
  • Cysteine and methionine metabolism, conserved biosystem (from KEGG)
    Cysteine and methionine metabolism, conserved biosystemCysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted f...
  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Methionine degradation, organism-specific biosystem (from KEGG)
    Methionine degradation, organism-specific biosystemPathway module; Nucleotide and amino acid metabolism; Cysteine and methionine metabolism
  • Methionine degradation, conserved biosystem (from KEGG)
    Methionine degradation, conserved biosystemPathway module; Nucleotide and amino acid metabolism; Cysteine and methionine metabolism
  • Methionine salvage pathway, organism-specific biosystem (from KEGG)
    Methionine salvage pathway, organism-specific biosystemPathway module; Nucleotide and amino acid metabolism; Cysteine and methionine metabolism
  • Methionine salvage pathway, conserved biosystem (from KEGG)
    Methionine salvage pathway, conserved biosystemPathway module; Nucleotide and amino acid metabolism; Cysteine and methionine metabolism
  • Methylation, organism-specific biosystem (from REACTOME)
    Methylation, organism-specific biosystemMethylation is a common but minor pathway of Phase II conjugation compared to glucuronidation or sulfonation. The cofactor used in methylation conjugation is S-adenosylmethionine (SAM). SAM is the ...
  • Methylation Pathways, organism-specific biosystem (from WikiPathways)
    Methylation Pathways, organism-specific biosystem
    Methylation Pathways
  • One Carbon Metabolism, organism-specific biosystem (from WikiPathways)
    One Carbon Metabolism, organism-specific biosystemThis one-carbon metabolism pathway is centered around folate. Folate has two key carbon-carbon double bonds. Saturating one of them yields dihydrofolate (DHF) and adding an additional molecule of hyd...
  • Phase II conjugation, organism-specific biosystem (from REACTOME)
    Phase II conjugation, organism-specific biosystemPhase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involv...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • S-adenosyl-L-methionine biosynthesis, organism-specific biosystem (from BIOCYC)
    S-adenosyl-L-methionine biosynthesis, organism-specific biosystemGeneral Background It has been said that no biological compound functions in as many different types of biological reactionsas : S-ADENOSYLMETHIONINE (known as SAM or AdoMet). It is probably second ...
  • Trans-sulfuration and one carbon metabolism, organism-specific biosystem (from WikiPathways)
    Trans-sulfuration and one carbon metabolism, organism-specific biosystem
    Trans-sulfuration and one carbon metabolism
  • Trans-sulfuration pathway, organism-specific biosystem (from WikiPathways)
    Trans-sulfuration pathway, organism-specific biosystemTrans-sulfuration pathway, the pathway of production of GSH from S-adenosylmethionine (SAMe). Evidences have been showed that this pathway was perturbed in liver toxicity studies.
  • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
    Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...
  • cysteine biosynthesis, organism-specific biosystem (from BIOCYC)
    cysteine biosynthesis, organism-specific biosystemGeneral Background While : CYS is considered a nonessential amino acid, it may become an essential amino acid in individuals with cetain metabolic diseases, infants and the elderly. In mammals, : CY...
  • methionine degradation, organism-specific biosystem (from BIOCYC)
    methionine degradation, organism-specific biosystemGeneral Background In mammals, : MET is an essential amino acid, it is not synthesized and must be obtained in the diet. : MET "Methionine" is catabolized to : HOMO-CYS via : S-ADENOSYLMETHIONINE (S...
  • methionine salvage cycle III, organism-specific biosystem (from BIOCYC)
    methionine salvage cycle III, organism-specific biosystem
    methionine salvage cycle III
  • superpathway of methionine degradation, organism-specific biosystem (from BIOCYC)
    superpathway of methionine degradation, organism-specific biosystem
    superpathway of methionine degradation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12237

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
methionine adenosyltransferase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methionine adenosyltransferase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
S-adenosylmethionine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
S-adenosylmethionine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
S-adenosylmethionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
methylation TAS
Traceable Author Statement
more info
 
one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
methionine adenosyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methionine adenosyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
methionine adenosyltransferase 2 subunit beta
Names
MAT II beta
beta regulatory subunit of methionine adenosyltransferase
dTDP-4-keto-6-deoxy-D-glucose 4-reductase
methionine adenosyltransferase II, beta
putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase
putative protein product of Nbla02999
short chain dehydrogenase/reductase family 23E, member 1
testicular tissue protein Li 118
NP_037415.1
NP_877725.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013283.5NP_037415.1  methionine adenosyltransferase 2 subunit beta isoform 1

    See identical proteins and their annotated locations for NP_037415.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC112205, AK096178, AK312365, HY366761
    Consensus CDS
    CCDS4365.1
    UniProtKB/Swiss-Prot
    Q9NZL9
    UniProtKB/TrEMBL
    A0A140VJP2
    Related
    ENSP00000325425.6, ENST00000321757.11
    Conserved Domains (1) summary
    cd05254
    Location:30316
    dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs
  2. NM_182796.2NP_877725.1  methionine adenosyltransferase 2 subunit beta isoform 2

    See identical proteins and their annotated locations for NP_877725.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region but maintains the reading frame, compared to variant 1. These differences result in a shorter isoform (2) with a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK096178, AY358695, HY091756, HY366761
    Consensus CDS
    CCDS4364.1
    UniProtKB/Swiss-Prot
    Q9NZL9
    Related
    ENSP00000280969.5, ENST00000280969.9
    Conserved Domains (1) summary
    cd05254
    Location:19305
    dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    163503064..163519354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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