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MAT2B methionine adenosyltransferase 2B [ Homo sapiens (human) ]

Gene ID: 27430, updated on 26-Jul-2021

Summary

Official Symbol
MAT2Bprovided by HGNC
Official Full Name
methionine adenosyltransferase 2Bprovided by HGNC
Primary source
HGNC:HGNC:6905
See related
Ensembl:ENSG00000038274 MIM:605527
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TGR; MAT-II; SDR23E1; MATIIbeta; Nbla02999
Summary
The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in lymph node (RPKM 45.7), thyroid (RPKM 43.7) and 25 other tissues See more
Orthologs
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Genomic context

See MAT2B in Genome Data Viewer
Location:
5q34
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (163503064..163519354)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (162930070..162946360)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene cyclin G1 Neighboring gene NudC domain containing 2 Neighboring gene hyaluronan mediated motility receptor Neighboring gene HMMR antisense RNA 1 Neighboring gene uncharacterized LOC102724458 Neighboring gene RNA, U6 small nuclear 168, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
GeneReviews: Not available
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
GeneReviews: Not available
Genome-wide association study of smoking behaviours among Bangladeshi adults.
GeneReviews: Not available
Linkage and association of successful aging to the 6q25 region in large Amish kindreds.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12237

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables methionine adenosyltransferase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methionine adenosyltransferase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in S-adenosylmethionine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in S-adenosylmethionine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in S-adenosylmethionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
methionine adenosyltransferase 2 subunit beta
Names
MAT II beta
beta regulatory subunit of methionine adenosyltransferase
dTDP-4-keto-6-deoxy-D-glucose 4-reductase
methionine adenosyltransferase II, beta
putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase
putative protein product of Nbla02999
short chain dehydrogenase/reductase family 23E, member 1
testicular tissue protein Li 118
NP_037415.1
NP_877725.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013283.5NP_037415.1  methionine adenosyltransferase 2 subunit beta isoform 1

    See identical proteins and their annotated locations for NP_037415.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC112205, AK096178, AK312365, HY366761
    Consensus CDS
    CCDS4365.1
    UniProtKB/Swiss-Prot
    Q9NZL9
    UniProtKB/TrEMBL
    A0A140VJP2
    Related
    ENSP00000325425.6, ENST00000321757.11
    Conserved Domains (1) summary
    cd05254
    Location:30316
    dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs
  2. NM_182796.2NP_877725.1  methionine adenosyltransferase 2 subunit beta isoform 2

    See identical proteins and their annotated locations for NP_877725.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region but maintains the reading frame, compared to variant 1. These differences result in a shorter isoform (2) with a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK096178, AY358695, HY091756, HY366761
    Consensus CDS
    CCDS4364.1
    UniProtKB/Swiss-Prot
    Q9NZL9
    Related
    ENSP00000280969.5, ENST00000280969.9
    Conserved Domains (1) summary
    cd05254
    Location:19305
    dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    163503064..163519354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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