Atp5l ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp5lprovided by MGI
Official Full Name: ATP synthase, H+ transporting, mitochondrial F0 complex, subunit Gprovided by MGI
Primary source: MGI:MGI:1351597
See related: Ensembl:ENSMUSG00000038717 AllianceGenome:MGI:1351597
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Atp5mg; 4933437C06Rik
Summary: Predicted to enable P-type proton-exporting transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in ATP synthesis coupled proton transport. Predicted to act upstream of or within ATP biosynthetic process and ion transport. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; central nervous system; cranium; eye; and genitourinary system. Orthologous to several human genes including ATP5MG (ATP synthase membrane subunit g). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 309.5), kidney adult (RPKM 211.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9; 9 A5.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (44824546..44832470, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (44913248..44920742, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

Homology

Homologs of the Atp5l gene: The Atp5l gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 456 organisms have orthologs with human gene Atp5l
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables P-type proton-exporting transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables proton transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to proton-transporting ATP synthase activity, rotational mechanism	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ATP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within proton motive force-driven ATP synthesis	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	HDA more info	PubMed
part_of mitochondrial proton-transporting ATP synthase complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of proton-transporting ATP synthase complex, coupling factor F(o)	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP synthase subunit g, mitochondrial

Names: ATP synthase membrane subunit g; ATPase subunit g; F1F0-ATP synthase g subunit

NP_038823.2

EC 3.6.1.14

XP_036010936.1

EC 3.6.1.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013795.5 → NP_038823.2 ATP synthase subunit g, mitochondrial

See identical proteins and their annotated locations for NP_038823.2

Status: VALIDATED

Source sequence(s)

BC086880, BY269662

Consensus CDS

CCDS40604.1

UniProtKB/Swiss-Prot

Q5M9M8, Q9CPQ8

UniProtKB/TrEMBL

A0A8C6GT44

Related

ENSMUSP00000047960.8, ENSMUST00000043675.9

Conserved Domains (1) summary

pfam04718
Location:10 → 101

ATP-synt_G; Mitochondrial ATP synthase g subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

44824546..44832470 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155043.1 → XP_036010936.1 ATP synthase subunit g, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q5M9M8

UniProtKB/TrEMBL

A0A8C6GT44

Conserved Domains (1) summary

pfam04718
Location:10 → 101

ATP-synt_G; Mitochondrial ATP synthase g subunit