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GLRA2 glycine receptor alpha 2 [ Homo sapiens (human) ]

Gene ID: 2742, updated on 28-Sep-2022

Summary

Official Symbol
GLRA2provided by HGNC
Official Full Name
glycine receptor alpha 2provided by HGNC
Primary source
HGNC:HGNC:4327
See related
Ensembl:ENSG00000101958 MIM:305990; AllianceGenome:HGNC:4327
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLR; MRXSP
Summary
The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Expression
Biased expression in brain (RPKM 1.9) and colon (RPKM 0.8) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See GLRA2 in Genome Data Viewer
Location:
Xp22.2
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (14448779..14731812)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (14109530..14312340)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (14547420..14749934)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene gem nuclear organelle associated protein 8 Neighboring gene ubiquitin conjugating enzyme E2 E4 pseudogene Neighboring gene uncharacterized LOC107985686 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:14691306-14692505 Neighboring gene FA complementation group B Neighboring gene nucleophosmin 1 pseudogene 9 Neighboring gene motile sperm domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to zinc ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chloride transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nervous system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to amino acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic transmission, glycinergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in glycinergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glycine receptor subunit alpha-2
Names
glycine receptor alpha 2 subunit
glycine receptor, alpha-2 polypeptide

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016459.3 RefSeqGene

    Range
    85759..288035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001118885.2NP_001112357.1  glycine receptor subunit alpha-2 isoform A precursor

    See identical proteins and their annotated locations for NP_001112357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (A).
    Source sequence(s)
    AA081959, AK312591, BC045547
    Consensus CDS
    CCDS14160.1
    UniProtKB/Swiss-Prot
    P23416, Q99862
    Conserved Domains (1) summary
    TIGR00860
    Location:46441
    LIC; Cation transporter family protein
  2. NM_001118886.2NP_001112358.1  glycine receptor subunit alpha-2 isoform B precursor

    See identical proteins and their annotated locations for NP_001112358.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon and lacks an exon, compared to variant 1, resulting in a protein (isoform B) of identical length but differing in 2 amino acids, compared to isoform A.
    Source sequence(s)
    AA081959, AK289561, AY437083, BC045547, DA495302
    Consensus CDS
    CCDS48085.1
    UniProtKB/Swiss-Prot
    P23416
    Related
    ENSP00000347123.4, ENST00000355020.8
    Conserved Domains (3) summary
    TIGR00860
    Location:46441
    LIC; Cation transporter family protein
    pfam02931
    Location:48254
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:261438
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
  3. NM_001171942.2NP_001165413.1  glycine receptor subunit alpha-2 isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (C) is shorter at the N-terminus compared to isoform A.
    Source sequence(s)
    AC003658, AK297304, AK312591, BC045547
    Consensus CDS
    CCDS55371.1
    UniProtKB/Swiss-Prot
    P23416
    Related
    ENSP00000387756.2, ENST00000443437.6
    Conserved Domains (1) summary
    cl27321
    Location:1352
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
  4. NM_002063.4NP_002054.1  glycine receptor subunit alpha-2 isoform A precursor

    See identical proteins and their annotated locations for NP_002054.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform A.
    Source sequence(s)
    AA081959, AY437083, BC045547, DA495302
    Consensus CDS
    CCDS14160.1
    UniProtKB/Swiss-Prot
    P23416, Q99862
    Related
    ENSP00000218075.4, ENST00000218075.9
    Conserved Domains (1) summary
    TIGR00860
    Location:46441
    LIC; Cation transporter family protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    14448779..14731812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441999.1XP_047297955.1  glycine receptor subunit alpha-2 isoform X2

    UniProtKB/Swiss-Prot
    Q99862
  2. XM_017029427.2XP_016884916.1  glycine receptor subunit alpha-2 isoform X1

    UniProtKB/Swiss-Prot
    P23416
    Conserved Domains (3) summary
    TIGR00860
    Location:46441
    LIC; Cation transporter family protein
    pfam02931
    Location:48254
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:261438
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
  3. XM_006724487.4XP_006724550.1  glycine receptor subunit alpha-2 isoform X3

    See identical proteins and their annotated locations for XP_006724550.1

    Conserved Domains (1) summary
    TIGR00860
    Location:30425
    LIC; Cation transporter family protein
  4. XM_047442000.1XP_047297956.1  glycine receptor subunit alpha-2 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    14109530..14312340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)