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GLRA2 glycine receptor alpha 2 [ Homo sapiens (human) ]

Gene ID: 2742, updated on 13-Aug-2020

Summary

Official Symbol
GLRA2provided by HGNC
Official Full Name
glycine receptor alpha 2provided by HGNC
Primary source
HGNC:HGNC:4327
See related
Ensembl:ENSG00000101958 MIM:305990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLR
Summary
The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Expression
Biased expression in brain (RPKM 1.9) and colon (RPKM 0.8) See more
Orthologs

Genomic context

See GLRA2 in Genome Data Viewer
Location:
Xp22.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (14529298..14731812)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (14547420..14749934)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene gem nuclear organelle associated protein 8 Neighboring gene ubiquitin conjugating enzyme E2 E4 pseudogene Neighboring gene uncharacterized LOC107985686 Neighboring gene Sharpr-MPRA regulatory region 3255 Neighboring gene FA complementation group B Neighboring gene nucleophosmin 1 pseudogene 9 Neighboring gene motile sperm domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellularly glycine-gated chloride channel activity IDA
Inferred from Direct Assay
more info
PubMed 
glycine binding IDA
Inferred from Direct Assay
more info
PubMed 
glycine-gated chloride ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to zinc ion IDA
Inferred from Direct Assay
more info
PubMed 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission TAS
Traceable Author Statement
more info
 
chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chloride transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
nervous system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to amino acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic transmission, glycinergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
glycinergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glycine receptor subunit alpha-2
Names
glycine receptor alpha 2 subunit
glycine receptor, alpha-2 polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016459.2 RefSeqGene

    Range
    5239..207515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001118885.2NP_001112357.1  glycine receptor subunit alpha-2 isoform A precursor

    See identical proteins and their annotated locations for NP_001112357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (A).
    Source sequence(s)
    AA081959, AK312591, BC045547
    Consensus CDS
    CCDS14160.1
    UniProtKB/Swiss-Prot
    P23416
    Conserved Domains (1) summary
    TIGR00860
    Location:46441
    LIC; Cation transporter family protein
  2. NM_001118886.2NP_001112358.1  glycine receptor subunit alpha-2 isoform B precursor

    See identical proteins and their annotated locations for NP_001112358.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon and lacks an exon, compared to variant 1, resulting in a protein (isoform B) of identical length but differing in 2 amino acids, compared to isoform A.
    Source sequence(s)
    AA081959, AK289561, AY437083, BC045547, DA495302
    Consensus CDS
    CCDS48085.1
    UniProtKB/Swiss-Prot
    P23416
    Related
    ENSP00000347123.4, ENST00000355020.8
    Conserved Domains (3) summary
    TIGR00860
    Location:46441
    LIC; Cation transporter family protein
    pfam02931
    Location:48254
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:261438
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
  3. NM_001171942.1NP_001165413.1  glycine receptor subunit alpha-2 isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (C) is shorter at the N-terminus compared to isoform A.
    Source sequence(s)
    AC003658, AK297304, AK312591, BC045547
    Consensus CDS
    CCDS55371.1
    UniProtKB/Swiss-Prot
    P23416
    Related
    ENSP00000387756.2, ENST00000443437.6
    Conserved Domains (1) summary
    cl27321
    Location:1352
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
  4. NM_002063.4NP_002054.1  glycine receptor subunit alpha-2 isoform A precursor

    See identical proteins and their annotated locations for NP_002054.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform A.
    Source sequence(s)
    AA081959, AY437083, BC045547, DA495302
    Consensus CDS
    CCDS14160.1
    UniProtKB/Swiss-Prot
    P23416
    Related
    ENSP00000218075.4, ENST00000218075.9
    Conserved Domains (1) summary
    TIGR00860
    Location:46441
    LIC; Cation transporter family protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    14529298..14731812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545496.2XP_011543798.1  glycine receptor subunit alpha-2 isoform X2

    See identical proteins and their annotated locations for XP_011543798.1

    Conserved Domains (1) summary
    TIGR00860
    Location:30425
    LIC; Cation transporter family protein
  2. XM_017029427.1XP_016884916.1  glycine receptor subunit alpha-2 isoform X1

    UniProtKB/Swiss-Prot
    P23416
    Conserved Domains (3) summary
    TIGR00860
    Location:46441
    LIC; Cation transporter family protein
    pfam02931
    Location:48254
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:261438
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
  3. XM_024452366.1XP_024308134.1  glycine receptor subunit alpha-2 isoform X3

    Conserved Domains (1) summary
    cl27321
    Location:1352
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
  4. XM_024452365.1XP_024308133.1  glycine receptor subunit alpha-2 isoform X2

    Conserved Domains (1) summary
    TIGR00860
    Location:30425
    LIC; Cation transporter family protein
  5. XM_017029429.2XP_016884918.1  glycine receptor subunit alpha-2 isoform X3

    UniProtKB/Swiss-Prot
    P23416
    Conserved Domains (1) summary
    cl27321
    Location:1352
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
  6. XM_017029428.2XP_016884917.1  glycine receptor subunit alpha-2 isoform X3

    UniProtKB/Swiss-Prot
    P23416
    Conserved Domains (1) summary
    cl27321
    Location:1352
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
  7. XM_006724487.3XP_006724550.1  glycine receptor subunit alpha-2 isoform X2

    See identical proteins and their annotated locations for XP_006724550.1

    Conserved Domains (1) summary
    TIGR00860
    Location:30425
    LIC; Cation transporter family protein
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