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Abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 [ Mus musculus (house mouse) ]

Gene ID: 27416, updated on 23-May-2018

Summary

Official Symbol
Abcc5provided by MGI
Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 5provided by MGI
Primary source
MGI:MGI:1351644
See related
Ensembl:ENSMUSG00000022822 Vega:OTTMUSG00000025954
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mrp5; Abcc5a; Abcc5b; AI132311; 2900011L11Rik
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that the human protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in CNS E18 (RPKM 26.0), CNS E14 (RPKM 23.9) and 26 other tissues See more
Orthologs

Genomic context

See Abcc5 in Genome Data Viewer
Location:
16 A3; 16 12.41 cM
Exon count:
34
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (20331303..20426394, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (20331376..20426467, complement)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene presenilin associated, rhomboid-like Neighboring gene cytochrome P450, family 2, subfamily ab, polypeptide 1 Neighboring gene predicted gene, 41432 Neighboring gene eukaryotic translation initiation factor 2B, subunit 5 epsilon

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC116567

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
ATPase activity, coupled to transmembrane movement of substances IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
organic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
organic anion transport IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
multidrug resistance-associated protein 5
Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 5a
ATP-binding cassette, sub-family C (CFTR/MRP), member 5b
ATP-binding cassette, sub-family C, member 5
MOAT-C
SMRP
multi-specific organic anion transporter C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013790.2NP_038818.2  multidrug resistance-associated protein 5 isoform 1

    See identical proteins and their annotated locations for NP_038818.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BB603250, BC090629
    Consensus CDS
    CCDS28045.1
    UniProtKB/Swiss-Prot
    Q9R1X5
    Related
    ENSMUSP00000078158.6, OTTMUSP00000031743, ENSMUST00000079158.12, OTTMUST00000064008
    Conserved Domains (4) summary
    cd03244
    Location:11901410
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:577759
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:1001429
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:8621142
    ABC_membrane; ABC transporter transmembrane region
  2. NM_176839.1NP_789809.1  multidrug resistance-associated protein 5 isoform 2

    See identical proteins and their annotated locations for NP_789809.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons but has two alternate 3' exons, as compared to variant 1. The encoded isoform (2) is much shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    BB603250, BC061132
    Consensus CDS
    CCDS28046.1
    UniProtKB/TrEMBL
    Q6P8Q2
    Related
    ENSMUSP00000093913.4, OTTMUSP00000031744, ENSMUST00000096199.4, OTTMUST00000064009
    Conserved Domains (1) summary
    PLN03232
    Location:100156
    PLN03232; ABC transporter C family member; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

    Range
    20331303..20426394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522208.3XP_006522271.1  multidrug resistance-associated protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006522271.1

    UniProtKB/Swiss-Prot
    Q9R1X5
    Conserved Domains (4) summary
    cd03244
    Location:11901410
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:577759
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:1001429
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:8621142
    ABC_membrane; ABC transporter transmembrane region
  2. XM_017317027.1XP_017172516.1  multidrug resistance-associated protein 5 isoform X3

  3. XM_006522209.3XP_006522272.1  multidrug resistance-associated protein 5 isoform X2

    Conserved Domains (4) summary
    cd03244
    Location:11491369
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:536718
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:591388
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:8211101
    ABC_membrane; ABC transporter transmembrane region
  4. XM_017317029.1XP_017172518.1  multidrug resistance-associated protein 5 isoform X4

    Conserved Domains (5) summary
    cd03244
    Location:718938
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:105287
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    COG1132
    Location:385959
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    TIGR02982
    Location:97289
    heterocyst_DevA; ABC exporter ATP-binding subunit, DevA family
    cl00549
    Location:390670
    ABC_membrane; ABC transporter transmembrane region
  5. XM_006522213.3XP_006522276.1  multidrug resistance-associated protein 5 isoform X4

    See identical proteins and their annotated locations for XP_006522276.1

    Conserved Domains (5) summary
    cd03244
    Location:718938
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:105287
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    COG1132
    Location:385959
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    TIGR02982
    Location:97289
    heterocyst_DevA; ABC exporter ATP-binding subunit, DevA family
    cl00549
    Location:390670
    ABC_membrane; ABC transporter transmembrane region
  6. XM_006522212.3XP_006522275.1  multidrug resistance-associated protein 5 isoform X4

    See identical proteins and their annotated locations for XP_006522275.1

    Conserved Domains (5) summary
    cd03244
    Location:718938
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:105287
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    COG1132
    Location:385959
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    TIGR02982
    Location:97289
    heterocyst_DevA; ABC exporter ATP-binding subunit, DevA family
    cl00549
    Location:390670
    ABC_membrane; ABC transporter transmembrane region
  7. XM_006522215.1XP_006522278.1  multidrug resistance-associated protein 5 isoform X5

    See identical proteins and their annotated locations for XP_006522278.1

    UniProtKB/TrEMBL
    Q6P8Q2
    Conserved Domains (1) summary
    PLN03232
    Location:100156
    PLN03232; ABC transporter C family member; Provisional
  8. XM_006522214.1XP_006522277.1  multidrug resistance-associated protein 5 isoform X5

    See identical proteins and their annotated locations for XP_006522277.1

    UniProtKB/TrEMBL
    Q6P8Q2
    Conserved Domains (1) summary
    PLN03232
    Location:100156
    PLN03232; ABC transporter C family member; Provisional

RNA

  1. XR_384569.1 RNA Sequence

  2. XR_384568.1 RNA Sequence

  3. XR_001781831.1 RNA Sequence

  4. XR_001781835.1 RNA Sequence

  5. XR_001781836.1 RNA Sequence

  6. XR_001781830.1 RNA Sequence

  7. XR_001781832.1 RNA Sequence

  8. XR_001781834.1 RNA Sequence

  9. XR_001781833.1 RNA Sequence

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