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Abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 [ Mus musculus (house mouse) ]

Gene ID: 27416, updated on 26-Sep-2020

Summary

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Official Symbol
Abcc5provided by MGI
Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 5provided by MGI
Primary source
MGI:MGI:1351644
See related
Ensembl:ENSMUSG00000022822
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mr; Abcc; Mrp5; Abcc5a; Abcc5b; AI132311; 2900011L11Rik
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that the human protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in CNS E18 (RPKM 26.0), CNS E14 (RPKM 23.9) and 26 other tissues See more
Orthologs
human all

Genomic context

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See Abcc5 in Genome Data Viewer
Location:
16 A3; 16 12.41 cM
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20150053..20245178, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20331303..20426428, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (20331376..20426467, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene presenilin associated, rhomboid-like Neighboring gene cytochrome P450, family 2, subfamily ab, polypeptide 1 Neighboring gene predicted gene, 41432 Neighboring gene eukaryotic translation initiation factor 2B, subunit 5 epsilon

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1. Cyranka M, et al. Obesity (Silver Spring), 2019 Aug. PMID 31338999, Free PMC Article
  2. Sepsis affects cardiac expression of multidrug resistance protein 5 (MRP5, ABCC5), an ABC-type CGMP export pump. Meissner K, et al. Shock, 2007 Nov. PMID 17589384
  3. ATP-binding Cassette Subfamily C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs. Jansen RS, et al. J Biol Chem, 2015 Dec 18. PMID 26515061, Free PMC Article
  4. Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5. Zhang Y, et al. J Biol Chem, 2015 Jun 12. PMID 25922079, Free PMC Article
  5. A family of drug transporters: the multidrug resistance-associated proteins. Borst P, et al. J Natl Cancer Inst, 2000 Aug 16. PMID 10944550

See all (28) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ABCC5 is a general glutamate conjugate and analog transporter that affects the disposition of endogenous metabolites, toxins, and drugs.
    Title: ATP-binding Cassette Subfamily C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs.
  2. Deficiency of MKP5 resulted in increased inflammatory activation in macrophages. These findings thus demonstrate that MKP5 critically controls inflammation in white adipose tissue and the development of metabolic disorders
    Title: Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5.
  3. Reduced cGMP export as a consequence of decreased MRP5 expression can attenuate heart failure in sepsis.
    Title: Sepsis affects cardiac expression of multidrug resistance protein 5 (MRP5, ABCC5), an ABC-type CGMP export pump.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC116567

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
  
ATPase activity IEA
Inferred from Electronic Annotation
more info
  
ATPase activity, coupled to transmembrane movement of substances IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
efflux transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
organic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
export across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
organic anion transport IEA
Inferred from Electronic Annotation
more info
  
transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
xenobiotic transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
endosome IEA
Inferred from Electronic Annotation
more info
  
integral component of membrane IEA
Inferred from Electronic Annotation
more info
  
membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
  
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
multidrug resistance-associated protein 5
Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 5a
ATP-binding cassette, sub-family C (CFTR/MRP), member 5b
ATP-binding cassette, sub-family C, member 5
MOAT-C
SMRP
multi-specific organic anion transporter C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013790.2 → NP_038818.2  multidrug resistance-associated protein 5 isoform 1

    See identical proteins and their annotated locations for NP_038818.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BB603250, BC090629
    Consensus CDS
    CCDS28045.1
    UniProtKB/Swiss-Prot
    Q9R1X5
    Related
    ENSMUSP00000078158.6, ENSMUST00000079158.12
    Conserved Domains (1) summary
    PLN03130
    Location:100 → 1424
    PLN03130; ABC transporter C family member; Provisional

  2. NM_176839.1 → NP_789809.1  multidrug resistance-associated protein 5 isoform 2

    See identical proteins and their annotated locations for NP_789809.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons but has two alternate 3' exons, as compared to variant 1. The encoded isoform (2) is much shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    BB603250, BC061132
    Consensus CDS
    CCDS28046.1
    UniProtKB/TrEMBL
    Q6P8Q2
    Related
    ENSMUSP00000093913.4, ENSMUST00000096199.4
    Conserved Domains (1) summary
    PLN03232
    Location:100 → 156
    PLN03232; ABC transporter C family member; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    20150053..20245178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522209.5 → XP_006522272.1  multidrug resistance-associated protein 5 isoform X2

  2. XM_030249146.2 → XP_030105006.1  multidrug resistance-associated protein 5 isoform X3

  3. XM_030249145.2 → XP_030105005.1  multidrug resistance-associated protein 5 isoform X3

  4. XM_036159973.1 → XP_036015866.1  multidrug resistance-associated protein 5 isoform X3

  5. XM_017317029.3 → XP_017172518.1  multidrug resistance-associated protein 5 isoform X4

    Conserved Domains (5) summary
    cd03244
    Location:718 → 938
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:105 → 287
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    COG1132
    Location:385 → 959
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    TIGR02982
    Location:97 → 289
    heterocyst_DevA; ABC exporter ATP-binding subunit, DevA family
    cl00549
    Location:390 → 670
    ABC_membrane; ABC transporter transmembrane region

  6. XM_006522213.5 → XP_006522276.1  multidrug resistance-associated protein 5 isoform X4

    See identical proteins and their annotated locations for XP_006522276.1

    Conserved Domains (5) summary
    cd03244
    Location:718 → 938
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:105 → 287
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    COG1132
    Location:385 → 959
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    TIGR02982
    Location:97 → 289
    heterocyst_DevA; ABC exporter ATP-binding subunit, DevA family
    cl00549
    Location:390 → 670
    ABC_membrane; ABC transporter transmembrane region

  7. XM_006522212.5 → XP_006522275.1  multidrug resistance-associated protein 5 isoform X4

    See identical proteins and their annotated locations for XP_006522275.1

  8. XM_006522208.4 → XP_006522271.1  multidrug resistance-associated protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006522271.1

    UniProtKB/Swiss-Prot
    Q9R1X5
    Conserved Domains (1) summary
    PLN03130
    Location:100 → 1424
    PLN03130; ABC transporter C family member; Provisional

  9. XM_030249144.2 → XP_030105004.1  multidrug resistance-associated protein 5 isoform X2

  10. XM_006522215.2 → XP_006522278.1  multidrug resistance-associated protein 5 isoform X5

    See identical proteins and their annotated locations for XP_006522278.1

    UniProtKB/TrEMBL
    Q6P8Q2
    Conserved Domains (1) summary
    PLN03232
    Location:100 → 156
    PLN03232; ABC transporter C family member; Provisional

  11. XM_006522214.2 → XP_006522277.1  multidrug resistance-associated protein 5 isoform X5

    See identical proteins and their annotated locations for XP_006522277.1

    UniProtKB/TrEMBL
    Q6P8Q2
    Conserved Domains (1) summary
    PLN03232
    Location:100 → 156
    PLN03232; ABC transporter C family member; Provisional

  12. XM_036159975.1 → XP_036015868.1  multidrug resistance-associated protein 5 isoform X5

    Conserved Domains (1) summary
    PLN03232
    Location:100 → 156
    PLN03232; ABC transporter C family member; Provisional

  13. XM_030249148.2 → XP_030105008.1  multidrug resistance-associated protein 5 isoform X5

    Conserved Domains (1) summary
    PLN03232
    Location:100 → 156
    PLN03232; ABC transporter C family member; Provisional

  14. XM_030249147.2 → XP_030105007.1  multidrug resistance-associated protein 5 isoform X5

    Conserved Domains (1) summary
    PLN03232
    Location:100 → 156
    PLN03232; ABC transporter C family member; Provisional

RNA

  1. XR_384569.1 RNA Sequence

  2. XR_384568.1 RNA Sequence

  3. XR_001781835.3 RNA Sequence

  4. XR_001781832.3 RNA Sequence

  5. XR_001781834.3 RNA Sequence

  6. XR_001781836.3 RNA Sequence

  7. XR_001781833.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1X5.2 GenPept UniProtKB/Swiss-Prot:Q9R1X5

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