U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mrpl15 mitochondrial ribosomal protein L15 [ Mus musculus (house mouse) ]

Gene ID: 27395, updated on 5-Feb-2023

Summary

Go to the top of the page Help
Official Symbol
Mrpl15provided by MGI
Official Full Name
mitochondrial ribosomal protein L15provided by MGI
Primary source
MGI:MGI:1351639
See related
Ensembl:ENSMUSG00000033845 AllianceGenome:MGI:1351639
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rpml7; MRP-L7; HSPC145
Summary
Predicted to be a structural constituent of ribosome. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in mitochondrion. Is expressed in several structures, including axial musculature; central nervous system; early conceptus; gonad; and liver. Orthologous to human MRPL15 (mitochondrial ribosomal protein L15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 6.3), CNS E11.5 (RPKM 5.1) and 26 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Mrpl15 in Genome Data Viewer
Location:
1; 1 A1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (4843421..4855973, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (4773198..4785750, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene transforming, acidic coiled-coil containing protein 3 pseudogene Neighboring gene pyruvate dehydrogenase (lipoamide) beta pseudogene Neighboring gene lysophospholipase 1 Neighboring gene uncharacterized LOC118567656

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences. O'Brien TW, et al. J Biol Chem, 1999 Dec 17. PMID 10593885
  2. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
  3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  4. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846
  5. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article

See all (28) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables structural constituent of ribosome ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within mitochondrial genome maintenance TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within translation ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
part_of large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of mitochondrial large ribosomal subunit ISA
Inferred from Sequence Alignment
more info
 PubMed 
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
39S ribosomal protein L15, mitochondrial
Names
L15mt
MRP-L15
ribosomal protein, mitochondrial, L7
NP_001171129.1
NP_079576.1
XP_006495587.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177658.1 → NP_001171129.1  39S ribosomal protein L15, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_001171129.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI836668, AK003367, AK017824, BC068230, BY083200, CX563035
    Consensus CDS
    CCDS48211.1
    UniProtKB/Swiss-Prot
    Q9CPR5, Q9CRH4
    Related
    ENSMUSP00000115512.2, ENSMUST00000156816.7
    Conserved Domains (1) summary
    pfam00828
    Location:52 → 175
    Ribosomal_L27A; Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A

  2. NM_025300.4 → NP_079576.1  39S ribosomal protein L15, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_079576.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternative acceptor splice site at the 3' terminal exon compared to variant 1, resulting in a frame-shift and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AI836668, AK017824, BC068230, BY083200
    Consensus CDS
    CCDS35504.1
    UniProtKB/Swiss-Prot
    Q9CPR5
    UniProtKB/TrEMBL
    A0A8C6HZ33
    Related
    ENSMUSP00000114649.2, ENSMUST00000130201.8
    Conserved Domains (1) summary
    pfam00828
    Location:52 → 175
    Ribosomal_L18e; Ribosomal protein L18e/L15

RNA

  1. NR_033530.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) is missing an internal exon compared to variant 1, resulting in a frame-shift and early translation termination, rendering this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI836668, AK017824, BC068230, BY083200

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    4843421..4855973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495524.4 → XP_006495587.2  39S ribosomal protein L15, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006495587.2

    UniProtKB/TrEMBL
    A0A0A6YVP4
    Related
    ENSMUSP00000141204.2, ENSMUST00000146665.3
    Conserved Domains (1) summary
    pfam00828
    Location:52 → 140
    Ribosomal_L27A; Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPR5.1 GenPept UniProtKB/Swiss-Prot:Q9CPR5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous