U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dusp13 dual specificity phosphatase 13 [ Mus musculus (house mouse) ]

Gene ID: 27389, updated on 20-Mar-2023

Summary

Go to the top of the page Help
Official Symbol
Dusp13provided by MGI
Official Full Name
dual specificity phosphatase 13provided by MGI
Primary source
MGI:MGI:1351599
See related
Ensembl:ENSMUSG00000021768 AllianceGenome:MGI:1351599
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MDSP; TMDP; Gm1203; DUSP13A; DUSP13B; TS-DSP6; LMW-DSP6
Summary
Enables protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in dephosphorylation and negative regulation of MAPK cascade. Predicted to be active in cytoplasm. Is expressed in ductus deferens; epididymis; ileum; and testis. Orthologous to human DUSP13 (dual specificity phosphatase 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 101.6) See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dusp13 in Genome Data Viewer
Location:
14; 14 A3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (21783460..21798704, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (21733395..21748651, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1600 Neighboring gene dual specificity phosphatase 29 Neighboring gene predicted gene 15935 Neighboring gene sterile alpha motif domain containing 8 Neighboring gene predicted gene, 23502

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis. Nakamura K, et al. Biochem J, 1999 Dec 15. PMID 10585869, Free PMC Article
  2. Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2. Chen HH, et al. J Biol Chem, 2004 Oct 1. PMID 15252030
  3. A novel phosphatase family, structurally related to dual-specificity phosphatases, that displays unique amino acid sequence and substrate specificity. Romá-Mateo C, et al. J Mol Biol, 2007 Dec 7. PMID 17976645
  4. Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Almind K, et al. Diabetes, 2003 Jun. PMID 12765967
  5. A growing family of dual specificity phosphatases with low molecular masses. Aoki N, et al. J Biochem, 2001 Jul. PMID 11432789

See all (20) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MAP kinase phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dual specificity protein phosphatase 13 isoform B; dual specificity protein phosphatase 13
Names
Dsp13-like protein
dual-specificity tyrosine phosphatase TS-DSP6
muscle-restricted DSP
testis and skeletal muscle-specific dual specificity phosphatase
testis- and skeletal muscle-specific DSP
NP_001361004.1
NP_001361006.1
NP_001361007.1
NP_001361008.1
NP_038877.2
XP_036014538.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374075.1 → NP_001361004.1  dual specificity protein phosphatase 13 isoform B isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC151533
    Consensus CDS
    CCDS88593.1
    UniProtKB/TrEMBL
    Z4YLI2
    Related
    ENSMUSP00000112552.3, ENSMUST00000119866.9
    Conserved Domains (1) summary
    cl28904
    Location:146 → 309
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. NM_001374077.1 → NP_001361006.1  dual specificity protein phosphatase 13 isoform B isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform 4.
    Source sequence(s)
    AC151533
    Consensus CDS
    CCDS88592.1
    UniProtKB/Swiss-Prot
    Q497R2
    UniProtKB/TrEMBL
    A0A6P7QI67
    Related
    ENSMUSP00000138972.2, ENSMUST00000184703.8
    Conserved Domains (1) summary
    cl28904
    Location:28 → 191
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. NM_001374078.1 → NP_001361007.1  dual specificity protein phosphatase 13 isoform B isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform 4.
    Source sequence(s)
    AC151533
    Consensus CDS
    CCDS88592.1
    UniProtKB/Swiss-Prot
    Q497R2
    UniProtKB/TrEMBL
    A0A6P7QI67
    Conserved Domains (1) summary
    cl28904
    Location:28 → 191
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  4. NM_001374079.1 → NP_001361008.1  dual specificity protein phosphatase 13 isoform B isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform 4.
    Source sequence(s)
    AC151533, BC100421
    UniProtKB/Swiss-Prot
    Q497R2
    UniProtKB/TrEMBL
    A0A6P7QI67
    Related
    ENSMUSP00000113985.2, ENSMUST00000120984.9
    Conserved Domains (1) summary
    cl28904
    Location:28 → 191
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  5. NM_013849.3 → NP_038877.2  dual specificity protein phosphatase 13 isoform B isoform 2

    See identical proteins and their annotated locations for NP_038877.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes isoform 2 (also called TMDP) and is found only in testis.
    Source sequence(s)
    AB027003, AK006247, BX629730
    Consensus CDS
    CCDS26864.1
    UniProtKB/Swiss-Prot
    Q9QYJ7
    UniProtKB/TrEMBL
    Q7TNW3, Q9DA25
    Related
    ENSMUSP00000113305.2, ENSMUST00000120956.8
    Conserved Domains (1) summary
    cd00127
    Location:110 → 253
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    21783460..21798704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158645.1 → XP_036014538.1  dual specificity protein phosphatase 13 isoform X1

    Conserved Domains (1) summary
    cl28904
    Location:154 → 317
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYJ7.1 GenPept UniProtKB/Swiss-Prot:Q9QYJ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous