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Akr1c13 aldo-keto reductase family 1, member C13 [ Mus musculus (house mouse) ]

Gene ID: 27384, updated on 13-Oct-2022

Summary

Official Symbol
Akr1c13provided by MGI
Official Full Name
aldo-keto reductase family 1, member C13provided by MGI
Primary source
MGI:MGI:1351662
See related
Ensembl:ENSMUSG00000021213 AllianceGenome:MGI:1351662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4014
Summary
Predicted to enable several functions, including oxidoreductase activity, acting on CH-OH group of donors; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; and oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Predicted to be involved in steroid metabolic process. Predicted to act upstream of or within xenobiotic metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in gut and liver lobe. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E18 (RPKM 17.2), large intestine adult (RPKM 12.8) and 17 other tissues See more
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Genomic context

See Akr1c13 in Genome Data Viewer
Location:
13; 13 A1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (4241166..4255603)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (4191168..4205604)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member C18 Neighboring gene solute carrier family 23 (nucleobase transporters), member 2 pseudogene Neighboring gene nuclear encoded tRNA lysine 6 (anticodon CTT) Neighboring gene aldo-keto reductase family 1, member C19

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Clone Names

  • KIAA4014

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alditol:NADP+ 1-oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aldo-keto reductase (NADP) activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables androsterone dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables chlordecone reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables ketosteroid monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
Inferred from Sequence Orthology
more info
 
enables retinal dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables steroid dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within xenobiotic metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
aldo-keto reductase family 1 member C13
Names
aldo-keto reductase AKR1C13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013778.2NP_038806.2  aldo-keto reductase family 1 member C13

    See identical proteins and their annotated locations for NP_038806.2

    Status: VALIDATED

    Source sequence(s)
    AK008949, AK220165
    Consensus CDS
    CCDS26220.1
    UniProtKB/Swiss-Prot
    Q8VC28, Q9R0M9
    UniProtKB/TrEMBL
    Q571M4
    Related
    ENSMUSP00000021634.3, ENSMUST00000021634.4
    Conserved Domains (2) summary
    COG0656
    Location:8307
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16297
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    4241166..4255603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516482.4XP_006516545.1  aldo-keto reductase family 1 member C13 isoform X1

    Conserved Domains (1) summary
    cd19108
    Location:30309
    AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)