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GLI4 GLI family zinc finger 4 [ Homo sapiens (human) ]

Gene ID: 2738, updated on 5-Jan-2022

Summary

Official Symbol
GLI4provided by HGNC
Official Full Name
GLI family zinc finger 4provided by HGNC
Primary source
HGNC:HGNC:4320
See related
Ensembl:ENSG00000250571 MIM:165280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HKR4; ZNF928
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in fat (RPKM 5.3), spleen (RPKM 4.2) and 25 other tissues See more
Orthologs
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Genomic context

See GLI4 in Genome Data Viewer
Location:
8q24.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (143267445..143276931)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144349615..144359101)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 Neighboring gene ZFP41 zinc finger protein Neighboring gene MYC-induced long non-coding RNA Neighboring gene zinc finger protein 696

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein GLI4
Names
GLI-Kruppel family member GLI4 (oncogene HKR4)
glioma-associated oncogene family zinc finger 4
krueppel-related zinc finger protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138465.4NP_612474.1  zinc finger protein GLI4

    See identical proteins and their annotated locations for NP_612474.1

    Status: VALIDATED

    Source sequence(s)
    AI829114, BC014165, BI761835
    Consensus CDS
    CCDS6398.1
    UniProtKB/Swiss-Prot
    P10075
    Related
    ENSP00000345024.1, ENST00000340042.2
    Conserved Domains (4) summary
    COG5048
    Location:181343
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:241261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:183205
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:281304
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    143267445..143276931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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